PMID- 32009327
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2092-7355 (Print)
IS  - 2092-7363 (Electronic)
IS  - 2092-7355 (Linking)
VI  - 12
IP  - 2
DP  - 2020 Mar
TI  - Delayed-Onset Anaphylaxis Caused by IgE Response to Influenza Vaccination.
PG  - 359-363
LID - 10.4168/aair.2020.12.2.359 [doi]
AB  - Influenza vaccine-associated anaphylaxis is a very rare allergic reaction to 
      vaccines, but the most concerning and life-threatening adverse reaction. Although 
      the safety of influenza vaccines has been well documented, occasional cases of 
      anaphylaxis in vaccinated patients have been reported. In this study, we analyzed 
      the immunoglobulin E (IgE) response to whole influenza vaccines in a pediatric 
      case of delayed-onset anaphylaxis after influenza vaccination. The patient showed 
      elevated specific IgE levels against whole influenza vaccines, especially with 
      split virion from egg-based manufacturing process. Specific IgE levels to 
      influenza vaccines showed decreased over. We evaluated a causal relationship 
      between influenza vaccine and anaphylaxis event by enzyme-linked immunosorbent 
      assay. Delayed-onset anaphylaxis after influenza vaccination can occur in 
      children without predisposing allergic diseases. In addition, the results 
      suggested that formulation and production system of influenza vaccines could 
      affect the probability of severe allergic reaction to vaccines.
CI  - Copyright (c) 2020 The Korean Academy of Asthma, Allergy and Clinical Immunology . 
      The Korean Academy of Pediatric Allergy and Respiratory Disease.
FAU - Kim, Min Jung
AU  - Kim MJ
AUID- ORCID: 0000-0002-5634-9709
AD  - Department of Pediatrics, Severance Hospital, Institute of Allergy, Institute for 
      Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical 
      Science, Yonsei University College of Medicine, Seoul, Korea.
AD  - Department of Microbiology and Immunology, Institute for Immunology and 
      Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei 
      University College of Medicine, Seoul, Korea.
FAU - Shim, Doo Hee
AU  - Shim DH
AUID- ORCID: 0000-0002-6696-7199
AD  - Department of Microbiology and Immunology, Institute for Immunology and 
      Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei 
      University College of Medicine, Seoul, Korea.
FAU - Cha, Hye Ran
AU  - Cha HR
AUID- ORCID: 0000-0001-7112-7525
AD  - Department of Microbiology and Immunology, Institute for Immunology and 
      Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei 
      University College of Medicine, Seoul, Korea.
FAU - Kim, Cheong Bi
AU  - Kim CB
AUID- ORCID: 0000-0002-9791-4639
AD  - Department of Microbiology and Immunology, Institute for Immunology and 
      Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei 
      University College of Medicine, Seoul, Korea.
FAU - Kim, Soo Yeon
AU  - Kim SY
AUID- ORCID: 0000-0003-4965-6193
AD  - Department of Pediatrics, Severance Hospital, Institute of Allergy, Institute for 
      Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical 
      Science, Yonsei University College of Medicine, Seoul, Korea.
FAU - Park, Jeon Han
AU  - Park JH
AUID- ORCID: 0000-0001-9604-3205
AD  - Department of Microbiology and Immunology, Institute for Immunology and 
      Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei 
      University College of Medicine, Seoul, Korea.
FAU - Sohn, Myung Hyun
AU  - Sohn MH
AUID- ORCID: 0000-0002-2478-487X
AD  - Department of Pediatrics, Severance Hospital, Institute of Allergy, Institute for 
      Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical 
      Science, Yonsei University College of Medicine, Seoul, Korea.
FAU - Lee, Jae Myun
AU  - Lee JM
AUID- ORCID: 0000-0002-5273-3113
AD  - Department of Microbiology and Immunology, Institute for Immunology and 
      Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei 
      University College of Medicine, Seoul, Korea. jaemyun@yuhs.ac.
FAU - Kim, Kyung Won
AU  - Kim KW
AUID- ORCID: 0000-0003-4529-6135
AD  - Department of Pediatrics, Severance Hospital, Institute of Allergy, Institute for 
      Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical 
      Science, Yonsei University College of Medicine, Seoul, Korea. kwkim@yuhs.ac.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - Allergy Asthma Immunol Res
JT  - Allergy, asthma & immunology research
JID - 101518382
PMC - PMC6997288
OTO - NOTNLM
OT  - Anaphylaxis
OT  - delayed hypersensitivity
OT  - drug hypersensitivity
OT  - immunoglobulin E
OT  - influenza
OT  - vaccination
OT  - vaccines
COIS- There is no financial or other issue that might lead to a conflict of interest.
EDAT- 2020/02/06 06:00
MHDA- 2020/02/06 06:01
PMCR- 2020/03/01
CRDT- 2020/02/04 06:00
PHST- 2019/09/11 00:00 [received]
PHST- 2019/10/28 00:00 [revised]
PHST- 2019/11/08 00:00 [accepted]
PHST- 2020/02/04 06:00 [entrez]
PHST- 2020/02/06 06:00 [pubmed]
PHST- 2020/02/06 06:01 [medline]
PHST- 2020/03/01 00:00 [pmc-release]
AID - 12.359 [pii]
AID - 10.4168/aair.2020.12.2.359 [doi]
PST - ppublish
SO  - Allergy Asthma Immunol Res. 2020 Mar;12(2):359-363. doi: 
      10.4168/aair.2020.12.2.359.