PMID- 32010391
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1857-9655 (Print)
IS  - 1857-9655 (Electronic)
IS  - 1857-9655 (Linking)
VI  - 7
IP  - 21
DP  - 2019 Nov 15
TI  - Preparation and Histological Study of Multi-Walled Carbon Nanotubes Bone Graft in 
      Management of Class II Furcation Defects in Dogs.
PG  - 3634-3641
LID - 10.3889/oamjms.2019.738 [doi]
AB  - BACKGROUND: The main target of periodontal disease and alveolar bone defeat 
      treatment is the regeneration of the lost structures. AIM: This work deals with 
      the evaluation of the effect of functionalised multi-walled carbon nanotubes 
      (MWCNTs), as grafting material in the management of furcation defects created in 
      dogs. MATERIAL AND METHODS: Potential cytotoxicity of the grafting material was 
      assessed. Scanning electron microscope (SEM) and energy dispersive x-ray (EDX) 
      analysis after incubation of the grafting material in simulated body fluid (SBF) 
      at pH 7.4 and 37 degrees C for one week was done. In six healthy mongrel dogs' 
      full-thickness mucoperiosteal flaps were raised on the buccal aspects to create 
      two walls intrabony defects at the furcation areas. The mandibular premolar area 
      received the grafting material. Histological evaluation was carried out at 1, 2- 
      and 3-months' period. RESULTS: Cytotoxicity results proved the safety of grafting 
      material application. The prepared material exhibited good Ca-apatite crystal 
      patterns at the surface revealed by SEM and high calcium content showed by EDX 
      results. Good bone formation ability was also apparent histologically. 
      CONCLUSION: The prepared grafting material (MWCNTs) can serve as a delivery 
      vehicle for osteogenic cells and osteogenic growth factor proteins in the bone 
      development process.
CI  - Copyright: (c) 2019 Ahmed A. Haroun, Basma Mostafa Zaki, Mahmoud Shalash, Reham A. 
      A. Morsy.
FAU - Haroun, Ahmed A
AU  - Haroun AA
AD  - Chemical Industries Research Division, National Research Centre, Cairo, Egypt.
FAU - Zaki, Basma Mostafa
AU  - Zaki BM
AD  - Oral and Dental Research Division, National Research Centre, Cairo, Egypt.
FAU - Shalash, Mahmoud
AU  - Shalash M
AD  - Oral and Dental Research Division, National Research Centre, Cairo, Egypt.
FAU - Morsy, Reham A A
AU  - Morsy RAA
AD  - Oral and Dental Research Division, National Research Centre, Cairo, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20191011
PL  - North Macedonia
TA  - Open Access Maced J Med Sci
JT  - Open access Macedonian journal of medical sciences
JID - 101662294
PMC - PMC6986499
OTO - NOTNLM
OT  - Bone graft
OT  - Bone regeneration
OT  - Furcation defects
OT  - Histological analysis
OT  - Multi-walled carbon nanotubes
EDAT- 2020/02/06 06:00
MHDA- 2020/02/06 06:01
PMCR- 2019/10/11
CRDT- 2020/02/04 06:00
PHST- 2019/07/03 00:00 [received]
PHST- 2019/09/25 00:00 [revised]
PHST- 2019/09/26 00:00 [accepted]
PHST- 2020/02/04 06:00 [entrez]
PHST- 2020/02/06 06:00 [pubmed]
PHST- 2020/02/06 06:01 [medline]
PHST- 2019/10/11 00:00 [pmc-release]
AID - OAMJMS-7-3634 [pii]
AID - 10.3889/oamjms.2019.738 [doi]
PST - epublish
SO  - Open Access Maced J Med Sci. 2019 Oct 11;7(21):3634-3641. doi: 
      10.3889/oamjms.2019.738. eCollection 2019 Nov 15.