PMID- 3201116
OWN - NLM
STAT- MEDLINE
DCOM- 19890117
LR  - 20190912
IS  - 0029-845X (Print)
IS  - 0029-845X (Linking)
VI  - 96
IP  - 5
DP  - 1988 Oct
TI  - Chemically induced inflammation in rat oral mucosa.
PG  - 428-34
AB  - The toxic, irritative, and sensitizing effects of topically applied sodium lauryl 
      sulfate (SLS), dithranol triacetate (DTA), nonanoic acid in methyl- or propyl 
      ester (NAM, NAP) in the buccal mucosa were investigated in a Sprague-Dawley rat 
      model. Semi-quantitative evaluations of cellular infiltrates were performed in 
      routine histologic preparations. The toxic potential was tested with 2% and 0.2% 
      solutions. All substances, except 0.2% SLS, caused an increased cellularity, 
      mainly of a mononuclear cell type. The low dose of NAM induced stronger 
      inflammatory reactions than the high dose. Repeated applications of 2% solutions 
      decreased the response compared to one application, except for NAM, where a clear 
      irritative potential was observed. Pre-exposure of dorsal skin prior to buccal 
      painting resulted in an enhanced reaction to NAM and NAP, whereas no sensitizing 
      capacity was noted in SLS or DTA in this model.
FAU - Ahlfors, E E
AU  - Ahlfors EE
AD  - Department of Oral Pathology, University of Lund, Malmo, Sweden.
FAU - Larsson, A
AU  - Larsson A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Scand J Dent Res
JT  - Scandinavian journal of dental research
JID - 0270023
RN  - 0 (Allergens)
RN  - 0 (Anti-Infective Agents, Local)
RN  - 0 (Fatty Acids)
RN  - 0 (Irritants)
RN  - 368GB5141J (Sodium Dodecyl Sulfate)
RN  - 5JQ8U9U95X (triacetyldithranol)
RN  - 97SEH7577T (pelargonic acid)
RN  - U8CJK0JH5M (Anthralin)
SB  - IM
MH  - Allergens
MH  - Animals
MH  - Anthralin/administration & dosage/adverse effects/*analogs & derivatives
MH  - Anti-Infective Agents, Local/administration & dosage/*adverse effects
MH  - Fatty Acids/administration & dosage/*adverse effects
MH  - *Irritants
MH  - Male
MH  - Mouth Mucosa/drug effects/pathology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Sodium Dodecyl Sulfate/administration & dosage/*adverse effects
MH  - Stomatitis/*chemically induced/pathology
EDAT- 1988/10/01 00:00
MHDA- 1988/10/01 00:01
CRDT- 1988/10/01 00:00
PHST- 1988/10/01 00:00 [pubmed]
PHST- 1988/10/01 00:01 [medline]
PHST- 1988/10/01 00:00 [entrez]
AID - 10.1111/j.1600-0722.1988.tb01579.x [doi]
PST - ppublish
SO  - Scand J Dent Res. 1988 Oct;96(5):428-34. doi: 10.1111/j.1600-0722.1988.tb01579.x.