PMID- 32011330
OWN - NLM
STAT- MEDLINE
DCOM- 20201117
LR  - 20240328
IS  - 2149-2271 (Electronic)
IS  - 2149-2263 (Print)
IS  - 2149-2263 (Linking)
VI  - 23
IP  - 2
DP  - 2020 Jan
TI  - Ten-year outcome of chronic thromboembolic pulmonary hypertension patients in a 
      tertiary center.
PG  - 105-109
LID - 10.14744/AnatolJCardiol.2019.90329 [doi]
AB  - OBJECTIVE: Chronic thromboembolic pulmonary hypertension (CTEPH) is one of the 
      leading causes of pulmonary hypertension (PH). We aimed to investigate the 
      outcome of CTEPH patients who were followed-up by a PH outpatient clinic. 
      METHODS: We screened the medical records of 29 PH patients who were followed-up 
      by a PH outpatient clinic between 2009 and 2018. The patients' demographics and 
      their clinical, echocardiographic, and hemodynamic characteristics were recorded. 
      RESULTS: Our study group consisted of 16 females (55.2%) and 13 males (44.8%). 
      The mean age was 59.5+/-13.7 years and the median follow-up duration was 44 months 
      (1-113 months). The mean initial 6-minute walking distance (6MWD) was 321.4+/-119.9 
      m. The initial median N-terminal pro brain natriuretic peptide (NT-proBNP) level 
      was 2468 pg/mL (46.1-20.564 pg/mL). All patients were on oral anticoagulant 
      therapy. Pulmonary endarterectomy (PEA) was performed in 17 of 29 patients 
      (58.6%). Twelve patients (41.4%) were not operated upon due to distal disease, 
      comorbidities, or their own preference. The operated patients were younger than 
      the non-operated patients (55 years & 65 years, p=0.04). At the follow-up, the 
      6MWD in the operated patients increased (+76 m) and decreased in non-operated 
      patients (-46 m). The survival rate at 10-year follow-up was 58.6% for the whole 
      group. Twelve patients died during the follow-up period. While 7 of 12 
      not-operated patients died (58.3%), just 5 of 17 operated patients (4 
      perioperatively and 1 at follow-up) died (29%). Advanced-stage final functional 
      capacity (FC) [New York Heart Association (NYHA) III-IV], inoperability, lower 
      final 6MWD, higher final NT-proBNP, and reduced tricuspid annular plane systolic 
      excursion (TAPSE) were associated with an increased mortality rate. Univariate 
      Cox regression analysis showed that patients with NYHA I-II final FC showed a 
      166-fold decreased mortality rate. CONCLUSION: The long-term prognosis of 
      operated patients is better than the outcome of not-operated patients. The 
      strongest predictor associated with mortality was a worse final FC (NYHA III-IV).
FAU - Kucukoglu, Mehmet Serdar
AU  - Kucukoglu MS
AD  - Department of Cardiology, Faculty of Medicine, Istanbul University, Cerrahpasa 
      Institute of Cardiology; Istanbul-Turkey.
FAU - Sinan, Umit Yasar
AU  - Sinan UY
AD  - Department of Cardiology, Faculty of Medicine, Istanbul University, Cerrahpasa 
      Institute of Cardiology; Istanbul-Turkey.
FAU - Yildizeli, Bedrettin
AU  - Yildizeli B
AD  - Department of Thoracic Surgery, Faculty of Medicine, Marmara University; 
      Istanbul-Turkey.
LA  - eng
PT  - Journal Article
PL  - Turkey
TA  - Anatol J Cardiol
JT  - Anatolian journal of cardiology
JID - 101652981
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Aged
MH  - Echocardiography
MH  - Female
MH  - Hemodynamics
MH  - Hospitals, University
MH  - Humans
MH  - Hypertension, Pulmonary/*complications
MH  - Male
MH  - Medical Records
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - Peptide Fragments/blood
MH  - Pulmonary Embolism/complications/diagnostic imaging/*mortality/therapy
MH  - Survival Analysis
MH  - Turkey
PMC - PMC7040873
COIS- Conflict of interest: None declared.
EDAT- 2020/02/06 06:00
MHDA- 2020/11/18 06:00
PMCR- 2020/02/01
CRDT- 2020/02/04 06:00
PHST- 2020/02/04 06:00 [entrez]
PHST- 2020/02/06 06:00 [pubmed]
PHST- 2020/11/18 06:00 [medline]
PHST- 2020/02/01 00:00 [pmc-release]
AID - AJC-23-105 [pii]
AID - 10.14744/AnatolJCardiol.2019.90329 [doi]
PST - ppublish
SO  - Anatol J Cardiol. 2020 Jan;23(2):105-109. doi: 
      10.14744/AnatolJCardiol.2019.90329.