PMID- 32011441
OWN - NLM
STAT- MEDLINE
DCOM- 20200218
LR  - 20200616
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 99
IP  - 3
DP  - 2020 Jan
TI  - Stretta procedure versus proton pump inhibitors for the treatment of nonerosive 
      reflux disease: A 6-month follow-up.
PG  - e18610
LID - 10.1097/MD.0000000000018610 [doi]
LID - e18610
AB  - To compare the Stretta procedure with proton pump inhibitors for the treatment of 
      nonerosive reflux disease (NERD).From July 2018 to April 2019, patients diagnosed 
      with NERD and referred for treatment were enrolled. They were treated with either 
      Stretta procedure or proton pump inhibitor (PPI) medication and followed-up for 6 
      months. The symptom control, quality of life, lower esophageal sphincter (LES) 
      pressure, 24-hour pH parameters, PPI usage and satisfaction rate were evaluated. 
      The complications were assessed. The outcomes of the 2 groups were analyzed and 
      compared.Twenty-eight patients in the Stretta group and 21 patients in the PPI 
      group completed the 6-month follow-up. No severe adverse events occurred in both 
      groups. Both interventions were effective in improvement of symptom and quality 
      of life. The symptom score improvement was significantly superior in the Stretta 
      group compared to the PPI group (6.3 +/- 3.4 vs 8.5 +/- 4.1, P = .03). LES pressure 
      increased significantly in the Stretta group compared to the PPI group 
      (14.2 +/- 4.4 mm Hg vs 10.0 +/- 4.0 mm Hg, P < .01). Although both interventions 
      improved 24-hour pH parameters, including number of acid episodes (P = .27), acid 
      exposure time (P = .39), and DeMeester score (P = .28), no difference was found 
      between the 2 groups. Complete PPI cessation rate (82% vs 52%, P = .03) as well 
      as satisfaction rate (89% vs 57%, P = .02) was much higher in Stretta group than 
      those in the PPI groupThe Stretta procedure was safe and effective in the short 
      term for the management of NERD. The Stretta procedure resulted in higher LES 
      pressure and achieved better improvement of symptom control and PPI cessation 
      than did PPI in the short term.
FAU - He, Suyu
AU  - He S
AD  - The Fourth Department of the Digestive Disease Center.
FAU - Xu, Fei
AU  - Xu F
AD  - The Fourth Department of the Digestive Disease Center.
FAU - Xiong, Xin
AU  - Xiong X
AD  - The Fourth Department of the Digestive Disease Center.
FAU - Wang, Hui
AU  - Wang H
AD  - The Fourth Department of the Digestive Disease Center.
FAU - Cao, Lipeng
AU  - Cao L
AD  - The Fifth Department of the Digestive Disease Center.
FAU - Liang, Ninglin
AU  - Liang N
AD  - The Fourth Department of the Digestive Disease Center.
FAU - Wang, Hanmei
AU  - Wang H
AD  - The Fourth Department of the Digestive Disease Center.
FAU - Jing, Xiaojuan
AU  - Jing X
AD  - The Endoscopy Center, Suining Central Hospital, Sichuan, China.
FAU - Liu, Tianyu
AU  - Liu T
AD  - The Fourth Department of the Digestive Disease Center.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adult
MH  - Catheter Ablation/adverse effects/*methods
MH  - Esophageal Sphincter, Lower/physiopathology
MH  - Female
MH  - Follow-Up Studies
MH  - Gastroesophageal Reflux/*therapy
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Male
MH  - Middle Aged
MH  - Patient Satisfaction
MH  - Proton Pump Inhibitors/adverse effects/*therapeutic use
MH  - Quality of Life
PMC - PMC7220108
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2020/02/06 06:00
MHDA- 2020/02/19 06:00
PMCR- 2020/01/17
CRDT- 2020/02/04 06:00
PHST- 2020/02/04 06:00 [entrez]
PHST- 2020/02/06 06:00 [pubmed]
PHST- 2020/02/19 06:00 [medline]
PHST- 2020/01/17 00:00 [pmc-release]
AID - 00005792-202001170-00012 [pii]
AID - MD-D-19-05950 [pii]
AID - 10.1097/MD.0000000000018610 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2020 Jan;99(3):e18610. doi: 10.1097/MD.0000000000018610.