PMID- 32012324
OWN - NLM
STAT- MEDLINE
DCOM- 20210331
LR  - 20210331
IS  - 1600-0560 (Electronic)
IS  - 0303-6987 (Linking)
VI  - 47
IP  - 7
DP  - 2020 Jul
TI  - A rare case of primary dermal clear cell sarcoma with focal epidermotropism: An 
      entity difficult to distinguish from melanoma.
PG  - 621-624
LID - 10.1111/cup.13659 [doi]
AB  - Clear cell sarcoma (CCS) is an uncommon soft-tissue sarcoma that only rarely 
      arises within the dermis. It is challenging to distinguish dermal CCS from 
      nodular, primary dermal, or metastatic melanoma, as they share morphologic 
      features and immunoprofiles. We describe a dermal CCS in a 25-year-old man with a 
      cutaneous groin mass. The lesion was initially diagnosed as melanoma, likely 
      metastatic. On consultation, in addition to a melanoma-like tumor in the dermis, 
      we identified focal infiltration of tumor cells into the overlying epidermis 
      (epidermotropism), resembling primary nodular or metastatic melanoma. Given the 
      patient's age and absence of a history of primary melanoma, fluorescence in situ 
      hybridization (FISH) was performed, which revealed separation of the 5' and 3' 
      EWSR1 probe signals on chromosome 22q12, prompting a diagnosis of CCS. Our case 
      highlights the histopathological, immunohistochemical, and ultrastructural 
      similarities between CCS and melanoma, and the consequent potential for major 
      diagnostic confusion. In such cases, FISH analysis remains the key to diagnosis. 
      CCS should be considered in patients with a melanoma-like tumor in the dermis or 
      subcutaneous tissue without epidermal (or with minimal) involvement, or prior to 
      diagnosing metastatic melanoma in the absence of a known history of primary 
      melanoma, especially in young individuals.
CI  - (c) 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Nawrocki, Shiri
AU  - Nawrocki S
AUID- ORCID: 0000-0002-4504-6833
AD  - Department of Dermatology, Rutgers-Robert Wood Johnson Medical School, New 
      Brunswick, New Jersey.
FAU - Fitzhugh, Valerie A
AU  - Fitzhugh VA
AD  - Department of Pathology and Laboratory Medicine, Rutgers-New Jersey Medical 
      School, Newark, New Jersey.
FAU - Groisberg, Roman
AU  - Groisberg R
AD  - Department of Medicine, Rutgers Cancer Institute of New Jersey, New Brunswick, 
      New Jersey.
FAU - Aviv, Hana A
AU  - Aviv HA
AD  - Department of Pathology and Laboratory Medicine, Rutgers Cancer Institute of New 
      Jersey, Rutgers-Robert Wood Johnson Medical School, New Brunswick, New Jersey.
FAU - Maghari, Amin
AU  - Maghari A
AD  - Department of Pathology and Laboratory Medicine, Rutgers-Robert Wood Johnson 
      Medical School, New Brunswick, New Jersey.
LA  - eng
PT  - Case Reports
DEP - 20200219
PL  - United States
TA  - J Cutan Pathol
JT  - Journal of cutaneous pathology
JID - 0425124
RN  - 0 (EWSR1-ATF1 fusion protein, human)
RN  - 0 (Oncogene Proteins, Fusion)
SB  - IM
MH  - Adult
MH  - Diagnosis, Differential
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Melanoma/*diagnosis
MH  - Oncogene Proteins, Fusion/genetics
MH  - Sarcoma, Clear Cell/*diagnosis/genetics/pathology
MH  - Skin Neoplasms/*diagnosis/genetics/pathology
OTO - NOTNLM
OT  - clear cell sarcoma
OT  - fluorescence in situ hybridization
OT  - melanoma
OT  - melanoma of soft parts
EDAT- 2020/02/06 06:00
MHDA- 2021/04/01 06:00
CRDT- 2020/02/04 06:00
PHST- 2019/08/18 00:00 [received]
PHST- 2020/01/06 00:00 [revised]
PHST- 2020/01/24 00:00 [accepted]
PHST- 2020/02/06 06:00 [pubmed]
PHST- 2021/04/01 06:00 [medline]
PHST- 2020/02/04 06:00 [entrez]
AID - 10.1111/cup.13659 [doi]
PST - ppublish
SO  - J Cutan Pathol. 2020 Jul;47(7):621-624. doi: 10.1111/cup.13659. Epub 2020 Feb 19.