PMID- 32013876
OWN - NLM
STAT- MEDLINE
DCOM- 20201013
LR  - 20201013
IS  - 1471-2261 (Electronic)
IS  - 1471-2261 (Linking)
VI  - 20
IP  - 1
DP  - 2020 Feb 3
TI  - Hyperhomocysteinemia accompany with metabolic syndrome increase the risk of left 
      ventricular hypertrophy in rural Chinese.
PG  - 44
LID - 10.1186/s12872-020-01350-2 [doi]
LID - 44
AB  - BACKGROUND: To investigate the influence of hyperhomocysteinemia (HHcy) and 
      metabolic syndrome (MetS) on left ventricular hypertrophy (LVH) in residents in 
      rural Northeast China. METHODS: We performed a cross-sectional baseline data 
      analysis of 6837 subjects (mean age: 54 +/- 10 years) recruited from a rural area 
      of China. Anthropometric indicators were measured according to standard methods. 
      MetS was defined by the modified ATP III criteria. HHcy was defined according to 
      the WHO standard: an Hcy level > 15 mumol/L representing HHcy. Four groups were 
      defined: non-HHcy & non-MetS, HHcy & non-MetS, MetS & non-HHcy and HHcy & MetS. 
      RESULTS: The left ventricular mass index for height(2.7) (LVMH(2.7)) in both 
      sexes was significantly higher in the HHcy & MetS group than in the non-HHcy & 
      non-MetS group (females: 51.23 +/- 16.34 vs. 40.09 +/- 10.55 g(-2.7), P < 0.001; 
      males: 48.67 +/- 12.24 g(-2.7) vs. 42.42 +/- 11.38 g(-2.7), P < 0.001). A similar 
      result was observed in those groups when using the left ventricular mass index 
      (LVMI) for body surface area to define LVH (females: 103.58 +/- 31.92 g(- 2) vs. 
      86.63 +/- 20.47 g(- 2), P < 0.001; males: 106.10 +/- 24.69 g(- 2) vs. 
      98.16 +/- 23.29 g(- 2), P < 0.001). The results of multiple regression analysis 
      indicated that the HHcy & MetS group had a higher risk of LVH than the other 
      three groups (OR: 1.628 for LVMI, P < 0.001, OR: 2.433 for LVMH(2.7), P < 0.001). 
      Moreover, subjects in the HHcy & non-MetS group [OR (95% CI): 1.297 (1.058, 
      1.591) for LVMI, P < 0.05; OR (95% CI): 1.248 (1.044, 1.492) for LVMH(2.7), 
      P < 0.05] also had a statistically greater risk of LVH than subjects in the 
      non-HHcy & non-MetS group. The HHcy & non-MetS group was also found to be 
      significantly and independently associated with LVH. CONCLUSION: 
      Hyperhomocysteinemia has an independent effect on LVH. The combined effect of 
      MetS and hyperhomocysteinemia might increase the strength of the abovementioned 
      effects.
FAU - Yu, Shasha
AU  - Yu S
AD  - Department of Cardiology, The First Hospital of China Medical University, 155 
      Nanjing North Street, Heping District, Shenyang, 110001, China.
FAU - Chen, Yintao
AU  - Chen Y
AD  - Department of Cardiology, The First Hospital of China Medical University, 155 
      Nanjing North Street, Heping District, Shenyang, 110001, China.
FAU - Yang, Hongmei
AU  - Yang H
AD  - Department of Cardiology, The First Hospital of China Medical University, 155 
      Nanjing North Street, Heping District, Shenyang, 110001, China.
FAU - Guo, Xiaofan
AU  - Guo X
AD  - Department of Cardiology, The First Hospital of China Medical University, 155 
      Nanjing North Street, Heping District, Shenyang, 110001, China.
FAU - Zheng, Liqiang
AU  - Zheng L
AD  - Department of Clinical Epidemiology, Shengjing Hospital of China Medical 
      University, Shenyang, 117004, China.
FAU - Sun, Yingxian
AU  - Sun Y
AUID- ORCID: 0000-0003-0592-2058
AD  - Department of Cardiology, The First Hospital of China Medical University, 155 
      Nanjing North Street, Heping District, Shenyang, 110001, China. 
      sunyingxian12@aliyun.com.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200203
PL  - England
TA  - BMC Cardiovasc Disord
JT  - BMC cardiovascular disorders
JID - 100968539
RN  - 0 (Biomarkers)
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - China/epidemiology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hyperhomocysteinemia/blood/diagnosis/*epidemiology
MH  - Hypertrophy, Left Ventricular/diagnostic imaging/*epidemiology/physiopathology
MH  - Male
MH  - Metabolic Syndrome/blood/diagnosis/*epidemiology
MH  - Middle Aged
MH  - Prevalence
MH  - Risk Assessment
MH  - Risk Factors
MH  - *Rural Health
MH  - *Ventricular Function, Left
MH  - *Ventricular Remodeling
PMC - PMC6998833
OTO - NOTNLM
OT  - Hyperhomocysteinemia
OT  - Left ventricular hypertrophy
OT  - Metabolic syndrome
OT  - Predictor
OT  - Rural
COIS- The authors declare that they have no competing interests.
EDAT- 2020/02/06 06:00
MHDA- 2020/10/21 06:00
PMCR- 2020/02/03
CRDT- 2020/02/05 06:00
PHST- 2019/11/05 00:00 [received]
PHST- 2020/01/20 00:00 [accepted]
PHST- 2020/02/05 06:00 [entrez]
PHST- 2020/02/06 06:00 [pubmed]
PHST- 2020/10/21 06:00 [medline]
PHST- 2020/02/03 00:00 [pmc-release]
AID - 10.1186/s12872-020-01350-2 [pii]
AID - 1350 [pii]
AID - 10.1186/s12872-020-01350-2 [doi]
PST - epublish
SO  - BMC Cardiovasc Disord. 2020 Feb 3;20(1):44. doi: 10.1186/s12872-020-01350-2.