PMID- 32014500
OWN - NLM
STAT- MEDLINE
DCOM- 20210618
LR  - 20220715
IS  - 1873-4596 (Electronic)
IS  - 0891-5849 (Linking)
VI  - 152
DP  - 2020 May 20
TI  - Photobiomodulation (450 nm) alters the infection of periodontitis bacteria via 
      the ROS/MAPK/mTOR signaling pathway.
PG  - 838-853
LID - S0891-5849(20)30008-3 [pii]
LID - 10.1016/j.freeradbiomed.2020.01.184 [doi]
AB  - We aimed to investigate the effects of photobiomodulation (PBM) on periodontitis. 
      A periodontitis model was established via Porphyromonas gingivalis infection in 
      beagles. Mandibular second and third premolars were removed, and implants were 
      positioned immediately after tooth extraction. Left gingiva was irradiated with 
      PBM (450 nm) as the LG group, and right side without irradiation was regarded as 
      the CG (control) group. PBM treatment increased oxidative stress by increasing 
      the levels of reactive oxygen species (ROS) and reactive nitrogen species (RNS). 
      The elevated levels of H(2)O(2) (a biomarker of oxidative stress) and the free 
      radicals (NO(*) and O(2)(*-)) reduced the concentration of dominant pathogens and 
      regulated ROS/RNS/AMP-activated protein kinase (AMPK)/mTOR pathway by affecting 
      p-AMPK, Runt-related transcription factor 2 (RUNX2), p-c-Jun N-terminal kinase 
      (JNK)/mammalian target of rapamycin (mTOR), and acetyl-CoA carboxylase 1 (ACC1). 
      PBM therapy increased salivary levels of interleukin-1 receptor antagonist 
      (IL-1ra), interleukin (IL)-10, total antioxidant capacity (TAC) and catalase 
      (CAT), and reduced the levels of tumor necrosis factor (TNF)alpha and interleukin 
      (IL)-1beta, malondialdehyde (MDA) and 8-hydroxydeoxyguanosine (8-OHdG) (p < 0.05). 
      All the results contributed to preventing periodontitis infection. PBM therapy 
      improved bone mineral density and implant osseointegration by controlling 
      dominant pathogens invasion via the upregulation of salivary anti-inflammatory 
      and antioxidant defense by affecting ROS/RNS/AMPK/mTOR signaling pathway.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Li, Hui
AU  - Li H
AD  - Department of Stomatology, China-Japan Union Hospital of Jilin University, 
      Changchun, 130033, China.
FAU - Sun, Tong
AU  - Sun T
AD  - Department of Breast Surgery, China-Japan Union Hospital of Jilin University, 
      Changchun, 130033, China.
FAU - Liu, Cong
AU  - Liu C
AD  - Department of Stomatology, Taian City Central Hospital, Taian, 271000, Shandong, 
      China.
FAU - Cao, Yan
AU  - Cao Y
AD  - Department of Stomatology, China-Japan Union Hospital of Jilin University, 
      Changchun, 130033, China.
FAU - Liu, Xin
AU  - Liu X
AD  - Department of Stomatology, China-Japan Union Hospital of Jilin University, 
      Changchun, 130033, China. Electronic address: liuxinjlu19@163.com.
LA  - eng
PT  - Journal Article
DEP - 20200131
PL  - United States
TA  - Free Radic Biol Med
JT  - Free radical biology & medicine
JID - 8709159
RN  - 0 (Reactive Oxygen Species)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Bacteria/metabolism
MH  - Dogs
MH  - *Hydrogen Peroxide
MH  - *Periodontitis/therapy
MH  - Reactive Oxygen Species
MH  - Signal Transduction
MH  - TOR Serine-Threonine Kinases/metabolism
OTO - NOTNLM
OT  - Anti-inflammation
OT  - Antioxidant
OT  - Implant osseointegration
OT  - Periodontitis
OT  - Photobiomodulation (450 nm)
OT  - Porphyromonas gingivalis
OT  - ROS/MAPK/mTOR signaling pathway
COIS- Declaration of competing interest The authors declare no competing interests.
EDAT- 2020/02/06 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/02/05 06:00
PHST- 2020/01/02 00:00 [received]
PHST- 2020/01/28 00:00 [revised]
PHST- 2020/01/28 00:00 [accepted]
PHST- 2020/02/06 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/02/05 06:00 [entrez]
AID - S0891-5849(20)30008-3 [pii]
AID - 10.1016/j.freeradbiomed.2020.01.184 [doi]
PST - ppublish
SO  - Free Radic Biol Med. 2020 May 20;152:838-853. doi: 
      10.1016/j.freeradbiomed.2020.01.184. Epub 2020 Jan 31.