PMID- 32014923
OWN - NLM
STAT- MEDLINE
DCOM- 20200319
LR  - 20200319
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 40
IP  - 2
DP  - 2020 Feb
TI  - Topoisomerase IIa Protein Expression Patterns in Laryngeal Squamous Cell 
      Carcinoma.
PG  - 807-811
LID - 10.21873/anticanres.14012 [doi]
AB  - BACKGROUND/AIM: Topoisomerase II alpha (TopoIIa) is a critical gene associated 
      with response to chemo-therapeutic agents, such as anthracyclines, especially in 
      breast adenocarcinoma. The aim of this study was to investigate the role of 
      aberrant TopoIIa protein expression in laryngeal squamous cell carcinoma (LSCC). 
      MATERIALS AND METHODS: Fifty (n=50) LSCC cases were enrolled in the study. 
      Immunohistochemistry and a digital image analysis assay were implemented. 
      RESULTS: TopoIIa protein overexpression was observed in 32/50 (64%) cases, 
      whereas low expression rates were detected in 18/50 (36%). TopoIIa overall 
      expression presented strong association with the grade of the examined malignant 
      tissues and borderline association with stage. TopoIIa overexpression correlated 
      also with Human papillomavirus (HPV) positivity. CONCLUSION: TopoIIa 
      overexpression was observed in significant subsets of LSCCs, and correlated 
      predominantly with the grade of differentiation. HPV persistent infection seems 
      to be associated with increased TopoIIa protein expression. TopoIIa expression 
      analysis appears to be critical in identifying sub-groups of patients eligible 
      for specific chemotherapy.
CI  - Copyright(c) 2020, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Papanikolaou, Vasileios
AU  - Papanikolaou V
AD  - First Department of Otorhinolaryngology, Head and Neck Surgery, Hippocration 
      Hospital, University of Athens, Athens, Greece.
FAU - Chrysovergis, Aristeidis
AU  - Chrysovergis A
AD  - First Department of Otorhinolaryngology, Head and Neck Surgery, Hippocration 
      Hospital, University of Athens, Athens, Greece.
FAU - Mastronikolis, Nicholas
AU  - Mastronikolis N
AD  - Department of Otorhinolaryngology, Medical School, University of Patras, Patras, 
      Greece.
FAU - Tsiambas, Evangelos
AU  - Tsiambas E
AD  - Department of Immunohistochemistry & Molecular Biology, 401 General Army 
      Hospital, Athens, Greece tsiambasecyto@yahoo.gr.
FAU - Ragos, Vasileios
AU  - Ragos V
AD  - Department of Maxillofacial, Medical School, University of Ioannina, Ioannina, 
      Greece.
FAU - Peschos, Dimitrios
AU  - Peschos D
AD  - Department of Physiology, Medical School, University of Ioannina, Ioannina, 
      Greece.
FAU - Stavraka, Chara
AU  - Stavraka C
AD  - Department of Medical Oncology, Guy's and St Thomas NHS Foundation Trust, London, 
      U.K.
FAU - Roukas, Dimitrios
AU  - Roukas D
AD  - Department of Psychiatry, 417 VA (NIMTS) Hospital, Athens, Greece.
FAU - Kyrodimos, Efthymios
AU  - Kyrodimos E
AD  - First Department of Otorhinolaryngology, Head and Neck Surgery, Hippocration 
      Hospital, University of Athens, Athens, Greece.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - EC 5.99.1.3 (DNA Topoisomerases, Type II)
SB  - IM
MH  - Carcinoma, Squamous Cell/*genetics/pathology
MH  - DNA Topoisomerases, Type II/*metabolism
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics/pathology
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - Larynx
OT  - carcinoma
OT  - digital image analysis
OT  - immunohistochemistry
OT  - topoisomerase
EDAT- 2020/02/06 06:00
MHDA- 2020/03/20 06:00
CRDT- 2020/02/05 06:00
PHST- 2019/12/02 00:00 [received]
PHST- 2019/12/12 00:00 [revised]
PHST- 2020/01/04 00:00 [accepted]
PHST- 2020/02/05 06:00 [entrez]
PHST- 2020/02/06 06:00 [pubmed]
PHST- 2020/03/20 06:00 [medline]
AID - 40/2/807 [pii]
AID - 10.21873/anticanres.14012 [doi]
PST - ppublish
SO  - Anticancer Res. 2020 Feb;40(2):807-811. doi: 10.21873/anticanres.14012.