PMID- 32015076
OWN - NLM
STAT- MEDLINE
DCOM- 20200914
LR  - 20210215
IS  - 1550-6606 (Electronic)
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 204
IP  - 4
DP  - 2020 Feb 15
TI  - Natural and Induced Tolerogenic Dendritic Cells.
PG  - 733-744
LID - 10.4049/jimmunol.1901121 [doi]
AB  - Dendritic cells (DCs) are highly susceptible to extrinsic signals that modify the 
      functions of these crucial APCs. Maturation of DCs induced by diverse 
      proinflammatory conditions promotes immune responses, but certain signals also 
      induce tolerogenic functions in DCs. These "induced tolerogenic DCs" help to 
      moderate immune responses such as those to commensals present at specific 
      anatomical locations. However, also under steady-state conditions, some DCs are 
      characterized by inherent tolerogenic properties. The immunomodulatory mechanisms 
      constitutively present in such "natural tolerogenic DCs" help to promote 
      tolerance to peripheral Ags. By extending tolerance initially established in the 
      thymus, these functions of DCs help to regulate autoimmune and other immune 
      responses. In this review we will discuss the mechanisms and functions of natural 
      and induced tolerogenic DCs and offer further insight into how their possible 
      manipulations may ultimately lead to more precise treatments for various 
      immune-mediated conditions and diseases.
CI  - Copyright (c) 2020 by The American Association of Immunologists, Inc.
FAU - Iberg, Courtney A
AU  - Iberg CA
AD  - Department of Molecular Microbiology and Immunology, Saint Louis University 
      School of Medicine, St. Louis, MO 63104.
FAU - Hawiger, Daniel
AU  - Hawiger D
AD  - Department of Molecular Microbiology and Immunology, Saint Louis University 
      School of Medicine, St. Louis, MO 63104 daniel.hawiger@health.slu.edu.
LA  - eng
GR  - R01 AI113903/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immune Tolerance/*immunology
PMC - PMC7006631
MID - NIHMS1541212
EDAT- 2020/02/06 06:00
MHDA- 2020/09/15 06:00
PMCR- 2021/02/15
CRDT- 2020/02/05 06:00
PHST- 2019/09/16 00:00 [received]
PHST- 2019/10/04 00:00 [accepted]
PHST- 2020/02/05 06:00 [entrez]
PHST- 2020/02/06 06:00 [pubmed]
PHST- 2020/09/15 06:00 [medline]
PHST- 2021/02/15 00:00 [pmc-release]
AID - 204/4/733 [pii]
AID - 10.4049/jimmunol.1901121 [doi]
PST - ppublish
SO  - J Immunol. 2020 Feb 15;204(4):733-744. doi: 10.4049/jimmunol.1901121.