PMID- 32016496
OWN - NLM
STAT- MEDLINE
DCOM- 20201021
LR  - 20201021
IS  - 1439-099X (Electronic)
IS  - 0179-7158 (Print)
IS  - 0179-7158 (Linking)
VI  - 196
IP  - 4
DP  - 2020 Apr
TI  - Dosimetric comparison of organs at risk using different contouring guidelines for 
      definition of the clinical target volume in anal cancer.
PG  - 368-375
LID - 10.1007/s00066-020-01587-y [doi]
AB  - BACKGROUND: There are different contouring guidelines for definition of the 
      clinical target volume (CTV) for intensity-modulated radiation therapy (IMRT) of 
      anal cancer (AC). We conducted a planning comparison study to evaluate and 
      compare the dose to relevant organs at risk (OARs) while using different CTV 
      definitions. METHODS: Twelve patients with a primary diagnosis of anal cancer, 
      who were treated with primary chemoradiation (CRT), were selected. We generated 
      four guideline-specific CTVs and subsequently planned target volumes (PTVs) on 
      the planning CT scan of each patient. An IMRT plan for volumetric arc therapy 
      (VMAT) was set up for each PTV. Dose parameters of the planned target volume 
      (PTV) and OARs were evaluated and compared, too. RESULTS: The mean volume of the 
      four PTVs ranged from 2138 cc to 2433 cc. The target volumes contoured by the 
      authors based on the recommendations of each group were similar in the pelvis, 
      while they differed significantly in the inguinal region. There were no 
      significant differences between the four target volumes with regard to the dose 
      parameters of the cranially located OARs. Conversely, some dose parameters 
      concerning the genitals and the skin varied significantly among the different 
      guidelines. CONCLUSION: The four contouring guidelines differ significantly 
      concerning the inguinal region. In order to avoid inguinal recurrence and to 
      protect relevant OARs, further investigations are needed to generate uniform 
      standards for definition of the elective clinical target volume in the inguinal 
      region.
FAU - Dapper, Hendrik
AU  - Dapper H
AD  - Department of Radiation Oncology, Klinikum rechts der Isar, TU Munchen, 
      Ismaninger Str. 22, 81675, Munich, Germany. Hendrik-dapper@gmx.de.
FAU - Oechsner, Markus
AU  - Oechsner M
AD  - Department of Radiation Oncology, Klinikum rechts der Isar, TU Munchen, 
      Ismaninger Str. 22, 81675, Munich, Germany.
FAU - Munch, Stefan
AU  - Munch S
AD  - Department of Radiation Oncology, Klinikum rechts der Isar, TU Munchen, 
      Ismaninger Str. 22, 81675, Munich, Germany.
AD  - Partner Site Munich, Deutsches Konsortium fur Translationale Krebsforschung 
      (DKTK), Munich, Germany.
FAU - Diehl, Christian
AU  - Diehl C
AD  - Department of Radiation Oncology, Klinikum rechts der Isar, TU Munchen, 
      Ismaninger Str. 22, 81675, Munich, Germany.
FAU - Peeken, Jan C
AU  - Peeken JC
AD  - Department of Radiation Oncology, Klinikum rechts der Isar, TU Munchen, 
      Ismaninger Str. 22, 81675, Munich, Germany.
AD  - Partner Site Munich, Deutsches Konsortium fur Translationale Krebsforschung 
      (DKTK), Munich, Germany.
AD  - Institute for Radiation Medicine (IRM), Helmholtz Zentrum Munchen, Ingolstadter 
      Landstr. 1, Neuherberg, 85764, Germany.
FAU - Borm, Kai
AU  - Borm K
AD  - Department of Radiation Oncology, Klinikum rechts der Isar, TU Munchen, 
      Ismaninger Str. 22, 81675, Munich, Germany.
FAU - Combs, Stephanie E
AU  - Combs SE
AD  - Department of Radiation Oncology, Klinikum rechts der Isar, TU Munchen, 
      Ismaninger Str. 22, 81675, Munich, Germany.
AD  - Partner Site Munich, Deutsches Konsortium fur Translationale Krebsforschung 
      (DKTK), Munich, Germany.
AD  - Institute for Radiation Medicine (IRM), Helmholtz Zentrum Munchen, Ingolstadter 
      Landstr. 1, Neuherberg, 85764, Germany.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20200203
PL  - Germany
TA  - Strahlenther Onkol
JT  - Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et 
      al]
JID - 8603469
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anus Neoplasms/pathology/*radiotherapy
MH  - Chemoradiotherapy, Adjuvant
MH  - Cohort Studies
MH  - Combined Modality Therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Organs at Risk/*radiation effects
MH  - *Radiometry
PMC - PMC7089901
OTO - NOTNLM
OT  - Anal cancer
OT  - Contouring guidelines
OT  - Dose distribution
OT  - Inguinal lymph nodes
OT  - Organs at risk
COIS- H. Dapper, M. Oechsner, S. Munch, C. Diehl, J.C. Peeken, K. Borm, and S.E. Combs 
      declare that they have no competing interests.
EDAT- 2020/02/06 06:00
MHDA- 2020/10/22 06:00
PMCR- 2020/02/03
CRDT- 2020/02/05 06:00
PHST- 2019/12/01 00:00 [received]
PHST- 2020/01/16 00:00 [accepted]
PHST- 2020/02/06 06:00 [pubmed]
PHST- 2020/10/22 06:00 [medline]
PHST- 2020/02/05 06:00 [entrez]
PHST- 2020/02/03 00:00 [pmc-release]
AID - 10.1007/s00066-020-01587-y [pii]
AID - 1587 [pii]
AID - 10.1007/s00066-020-01587-y [doi]
PST - ppublish
SO  - Strahlenther Onkol. 2020 Apr;196(4):368-375. doi: 10.1007/s00066-020-01587-y. 
      Epub 2020 Feb 3.