PMID- 32017138
OWN - NLM
STAT- MEDLINE
DCOM- 20210412
LR  - 20210412
IS  - 1525-1594 (Electronic)
IS  - 0160-564X (Linking)
VI  - 44
IP  - 7
DP  - 2020 Jul
TI  - Can heat therapy help patients with heart failure?
PG  - 680-692
LID - 10.1111/aor.13659 [doi]
AB  - To review and analyze the clinical outcomes of thermal therapy (</=1.4 degrees C increase 
      in core body temperature) in patients with heart failure (HF). A systematic 
      review and meta-analysis regarding the effects of thermal therapy on HF was done 
      by searching PubMed, Ovid Medline, Ovid Embase, Scopus, and internal databases up 
      to date (2019). Improvement in the New York Heart Association (NYHA) class: Ten 
      studies with 310 patients showed significant improvement in NYHA class. Only 7 
      among 40 patients remained in Class IV and 99 patients in Class III from 155 
      patients. Increased patients in lower classes indicate that more patients showed 
      improvement. Sixteen studies on 506 patients showed an overall improvement of 
      4.4% of left ventricular ejection fraction (LVEF). Four studies reported improved 
      endothelial dysfunction by 1.7% increase in flow-mediated dilation (FMD) on 130 
      patients. Reduction in blood pressure: Thermal therapy reduced both systolic 
      blood pressure (SBP) and diastolic blood pressure by 3.1% and 5.31%, 
      respectively, in 431 patients of 15 studies. Decrease in cardiothoracic ratio 
      (CTR): Eight studies reported an average of 5.55% reduction of CTR in a total of 
      347 patients. Improvement in oxidative stress markers: Plasma brain natriuretic 
      peptide (BNP) levels significantly decreased (mean difference of 14.8 pg/dL) in 
      303 patients of 9 studies. Improvement of quality of life: Among 65 patients, 
      thermal therapy reduced cardiac death and rehospitalization by 31.3%. A slight 
      increase in core body temperature is a promising, noninvasive, effective, and 
      complementary therapy for patients with HF. Further clinical studies are 
      recommended.
CI  - (c) 2020 International Center for Artificial Organs and Transplantation and Wiley 
      Periodicals, Inc.
FAU - Ye, Winnie N
AU  - Ye WN
AUID- ORCID: 0000-0003-2817-4531
AD  - Department of Electronics, Carleton University, Ottawa, ON, Canada.
FAU - Thipse, Madhura
AU  - Thipse M
AD  - Cardiovascular Devices Division, University of Ottawa Heart Institute, Ottawa, 
      ON, Canada.
FAU - Mahdi, Maleka Ben
AU  - Mahdi MB
AD  - Cardiovascular Devices Division, University of Ottawa Heart Institute, Ottawa, 
      ON, Canada.
FAU - Azad, Sharlin
AU  - Azad S
AD  - Cardiovascular Devices Division, University of Ottawa Heart Institute, Ottawa, 
      ON, Canada.
FAU - Davies, Ross
AU  - Davies R
AD  - Cardiovascular Devices Division, University of Ottawa Heart Institute, Ottawa, 
      ON, Canada.
FAU - Ruel, Marc
AU  - Ruel M
AD  - Cardiovascular Devices Division, University of Ottawa Heart Institute, Ottawa, 
      ON, Canada.
FAU - Silver, Marc A
AU  - Silver MA
AD  - Heart Failure Institute, Advocate Christ Medical Centre, Oak Lawn, IL, USA.
FAU - Hakami, Lale
AU  - Hakami L
AD  - Medical Center, University of Munich, Munich, Germany.
FAU - Mesana, Thierry
AU  - Mesana T
AD  - Cardiovascular Devices Division, University of Ottawa Heart Institute, Ottawa, 
      ON, Canada.
FAU - Leenen, Frans
AU  - Leenen F
AD  - Cardiovascular Devices Division, University of Ottawa Heart Institute, Ottawa, 
      ON, Canada.
FAU - Mussivand, Tofy
AU  - Mussivand T
AUID- ORCID: 0000-0003-2410-881X
AD  - Cardiovascular Devices Division, University of Ottawa Heart Institute, Ottawa, 
      ON, Canada.
LA  - eng
GR  - Cardiovascular Devices Division/
GR  - University of Ottawa Heart Institute/
GR  - NSERC/
GR  - CIHR/
GR  - OCE/
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20200308
PL  - United States
TA  - Artif Organs
JT  - Artificial organs
JID - 7802778
SB  - IM
MH  - Baths
MH  - Blood Pressure/physiology
MH  - Complementary Therapies/*methods
MH  - Heart Failure/complications/physiopathology/*therapy
MH  - Hot Temperature/*therapeutic use
MH  - Humans
MH  - Oxidative Stress/physiology
MH  - *Quality of Life
MH  - Steam Bath
MH  - Treatment Outcome
MH  - Ventricular Function, Left/physiology
OTO - NOTNLM
OT  - heart failure
OT  - heat therapy for heart failure
OT  - thermal therapy
EDAT- 2020/02/06 06:00
MHDA- 2021/04/13 06:00
CRDT- 2020/02/05 06:00
PHST- 2019/05/08 00:00 [received]
PHST- 2019/12/16 00:00 [revised]
PHST- 2020/01/30 00:00 [accepted]
PHST- 2020/02/06 06:00 [pubmed]
PHST- 2021/04/13 06:00 [medline]
PHST- 2020/02/05 06:00 [entrez]
AID - 10.1111/aor.13659 [doi]
PST - ppublish
SO  - Artif Organs. 2020 Jul;44(7):680-692. doi: 10.1111/aor.13659. Epub 2020 Mar 8.