PMID- 32017217 OWN - NLM STAT- MEDLINE DCOM- 20201214 LR - 20201214 IS - 1399-3038 (Electronic) IS - 0905-6157 (Linking) VI - 31 Suppl 24 DP - 2020 Feb TI - Eosinophilic esophagitis and other eosinophilic disorders of the gastrointestinal tract. PG - 25-27 LID - 10.1111/pai.13153 [doi] AB - Eosinophilic disorders of the gastrointestinal tract (EGID) are a group of diseases characterized by an eosinophilic inflammation limited to the GI tract. EoE is by far the most common EGID and is an atopic chronic/relapsing eosinophilic inflammation of the esophagus. It is now recognized as an increasingly common cause of esophageal dysfunction, fibrosis, stricture, and food impaction in children and adults. There are globally accepted guidelines for its treatment that are based on the use of proton pump inhibitors (PPI), corticosteroids, and diet. Many clinical trials have been published on the use of biologics in this disease. Non-EoE-EGID is a rare, more severe disease. No globally accepted guidelines exist for their treatment and diagnosis. Corticosteroids are at the moment the most effective treatment of those diseases. CI - (c) 2020 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd. FAU - Cianferoni, Antonella AU - Cianferoni A AUID- ORCID: 0000-0002-2966-2564 AD - Pediatrics Department, Perlman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. LA - eng PT - Journal Article PL - England TA - Pediatr Allergy Immunol JT - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JID - 9106718 RN - 0 (Adrenal Cortex Hormones) RN - 0 (Proton Pump Inhibitors) SB - IM MH - Adrenal Cortex Hormones/*therapeutic use MH - Adult MH - Child MH - Diet Therapy MH - Eosinophilic Esophagitis/*immunology/therapy MH - Esophagus/*pathology MH - Gastrointestinal Tract/*pathology MH - Humans MH - Inflammation/*immunology/therapy MH - Practice Guidelines as Topic MH - Proton Pump Inhibitors/*therapeutic use OTO - NOTNLM OT - biologics OT - diagnosis OT - diagnostics OT - diet therapy OT - eosinophilic colitis OT - eosinophilic esophagitis OT - eosinophilic gastritis OT - eosinophilic gastroenteritis physiopathology OT - etiology OT - treatment EDAT- 2020/02/06 06:00 MHDA- 2020/12/15 06:00 CRDT- 2020/02/05 06:00 PHST- 2019/10/21 00:00 [received] PHST- 2019/10/24 00:00 [accepted] PHST- 2020/02/05 06:00 [entrez] PHST- 2020/02/06 06:00 [pubmed] PHST- 2020/12/15 06:00 [medline] AID - 10.1111/pai.13153 [doi] PST - ppublish SO - Pediatr Allergy Immunol. 2020 Feb;31 Suppl 24:25-27. doi: 10.1111/pai.13153.