PMID- 32017334 OWN - NLM STAT- MEDLINE DCOM- 20210708 LR - 20210708 IS - 1520-7560 (Electronic) IS - 1520-7552 (Linking) VI - 36 IP - 5 DP - 2020 Jul TI - Baseline serum albumin and its dynamic change is associated with type 2 diabetes risk: A large cohort study in China. PG - e3296 LID - 10.1002/dmrr.3296 [doi] AB - BACKGROUND: The study aimed to investigate the associations of baseline serum albumin level and its dynamic change with type 2 diabetes mellitus (T2DM) risk in a large Chinese cohort study. METHODS: This cohort study included 30 442 adults without T2DM at first entry, who completed at least one follow-up of annual examinations between 2009 and 2016. Serum albumin level was measured at baseline and at every annual check-up. The dynamic change in serum albumin level (∆ALB) was calculated by subtracting serum albumin level at baseline from that at the last follow-up. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with Cox regression models. RESULTS: During 7 years of follow-up, we identified 1634 T2DM events. From the lowest to the highest quartile of serum albumin level, adjusted HRs (95% CI) were 1.00 (reference), 0.96 (0.94, 1.01), 0.98 (0.95, 1.02) and 0.88 (0.85, 0.98), respectively. As compared with stable change in serum albumin (-0.2 /=3.0 g/L (0.81, 0.68-0.97) after adjusting for potential confounding factors. Restricted cubic splines showed a linear dose-response association between baseline serum albumin level and T2DM risk (P(nonlinearity) 0.715) and a nonlinear dose-response association between ∆ALB and T2DM risk (P(nonlinearity) 0.011). CONCLUSIONS: Baseline serum albumin level appears to be inversely associated with T2DM risk. Adults with reduced serum albumin level could be early identified for diabetes risk in clinical practice. CI - (c) 2020 John Wiley & Sons Ltd. FAU - Hu, Fulan AU - Hu F AUID- ORCID: 0000-0002-2386-1503 AD - School of Public Health, Shenzhen University Health Science Center, Shenzhen, Guangdong, P. R. China. FAU - Lou, Yanmei AU - Lou Y AD - Department of Health Management, Beijing Xiaotangshan Hospital, Beijing, P. R. China. FAU - Shi, Jing AU - Shi J AD - Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin, Heilongjiang, P. R. China. FAU - Cao, Liming AU - Cao L AD - Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin, Heilongjiang, P. R. China. FAU - Wang, Changyi AU - Wang C AD - Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, Guangdong, P. R. China. FAU - Ma, Jianping AU - Ma J AD - Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, Guangdong, P. R. China. FAU - Peng, Xiaolin AU - Peng X AD - Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, Guangdong, P. R. China. FAU - Xu, Shan AU - Xu S AD - Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, Guangdong, P. R. China. FAU - Chen, Hongen AU - Chen H AD - Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, Guangdong, P. R. China. FAU - Zhao, Dan AU - Zhao D AD - Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, Guangdong, P. R. China. FAU - Zhao, Yang AU - Zhao Y AD - Department of Epidemiology and Health Statistics, School of Public Health, Zhengzhou University, Zhengzhou, Henan, P. R. China. FAU - Guo, Chunmei AU - Guo C AD - Department of Epidemiology and Health Statistics, School of Public Health, Zhengzhou University, Zhengzhou, Henan, P. R. China. FAU - Liu, Dechen AU - Liu D AD - Department of Epidemiology and Health Statistics, School of Public Health, Zhengzhou University, Zhengzhou, Henan, P. R. China. FAU - Zhou, Qionggui AU - Zhou Q AD - School of Public Health, Shenzhen University Health Science Center, Shenzhen, Guangdong, P. R. China. FAU - Li, Quanman AU - Li Q AD - Department of Epidemiology and Health Statistics, School of Public Health, Zhengzhou University, Zhengzhou, Henan, P. R. China. FAU - Liu, Feiyan AU - Liu F AD - School of Public Health, Shenzhen University Health Science Center, Shenzhen, Guangdong, P. R. China. FAU - Tian, Gang AU - Tian G AD - Department of Epidemiology and Health Statistics, School of Public Health, Zhengzhou University, Zhengzhou, Henan, P. R. China. FAU - Wu, Xiaoyan AU - Wu X AD - School of Public Health, Shenzhen University Health Science Center, Shenzhen, Guangdong, P. R. China. FAU - Qie, Ranran AU - Qie R AD - Department of Epidemiology and Health Statistics, School of Public Health, Zhengzhou University, Zhengzhou, Henan, P. R. China. FAU - Han, Minghui AU - Han M AD - Department of Epidemiology and Health Statistics, School of Public Health, Zhengzhou University, Zhengzhou, Henan, P. R. China. FAU - Huang, Shengbing AU - Huang S AD - Department of Epidemiology and Health Statistics, School of Public Health, Zhengzhou University, Zhengzhou, Henan, P. R. China. FAU - Zhao, Ping AU - Zhao P AD - Department of Health Management, Beijing Xiaotangshan Hospital, Beijing, P. R. China. FAU - Zhang, Ming AU - Zhang M AD - School of Public Health, Shenzhen University Health Science Center, Shenzhen, Guangdong, P. R. China. FAU - Hu, Dongsheng AU - Hu D AUID- ORCID: 0000-0002-9998-8041 AD - School of Public Health, Shenzhen University Health Science Center, Shenzhen, Guangdong, P. R. China. AD - Department of Epidemiology and Health Statistics, School of Public Health, Zhengzhou University, Zhengzhou, Henan, P. R. China. FAU - Qin, Pei AU - Qin P AUID- ORCID: 0000-0003-2303-0379 AD - School of Public Health, Shenzhen University Health Science Center, Shenzhen, Guangdong, P. R. China. LA - eng GR - 2017057/Nanshan Science and Technology Innovation Bureau/International GR - 81373074/National Natural Science Foundation of China/International GR - 2017A030313452/Natural Science Foundation of Guangdong Province/International GR - SZSM201803080/Sanming Project of Medicine in Shenzhen/International GR - A2017181/the Medical Research Foundation of Guangdong Province/International GR - CYJ20140418091413562/the Science and Technology Development Foundation of Shenzhen/International GR - JCYJ20160307155707264/Science and Technology Development Foundation of Shenzhen/International GR - JCYJ20170302143855721/Science and Technology Development Foundation of Shenzhen/International GR - JCYJ20170412110537191/Science and Technology Development Foundation of Shenzhen/International GR - 81402752/Natural Science Foundation of Guangdong Province/International GR - 81673260/Natural Science Foundation of Guangdong Province/International PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200220 PL - England TA - Diabetes Metab Res Rev JT - Diabetes/metabolism research and reviews JID - 100883450 RN - 0 (Biomarkers) RN - 0 (Blood Glucose) RN - 0 (Serum Albumin) SB - IM MH - Adult MH - Biomarkers/*analysis MH - Blood Glucose/*analysis MH - Body Mass Index MH - China/epidemiology MH - Cohort Studies MH - Diabetes Mellitus, Type 2/blood/*epidemiology MH - Female MH - Follow-Up Studies MH - Humans MH - Incidence MH - Male MH - Middle Aged MH - Prognosis MH - Risk Factors MH - Serum Albumin/*analysis OTO - NOTNLM OT - Chinese OT - cohort study OT - diabetes OT - dynamic change OT - serum albumin EDAT- 2020/02/06 06:00 MHDA- 2021/07/09 06:00 CRDT- 2020/02/05 06:00 PHST- 2019/08/12 00:00 [received] PHST- 2019/12/31 00:00 [revised] PHST- 2020/01/22 00:00 [accepted] PHST- 2020/02/06 06:00 [pubmed] PHST- 2021/07/09 06:00 [medline] PHST- 2020/02/05 06:00 [entrez] AID - 10.1002/dmrr.3296 [doi] PST - ppublish SO - Diabetes Metab Res Rev. 2020 Jul;36(5):e3296. doi: 10.1002/dmrr.3296. Epub 2020 Feb 20.