PMID- 32018252
OWN - NLM
STAT- MEDLINE
DCOM- 20200807
LR  - 20200807
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 181
IP  - 4
DP  - 2020
TI  - Perinatal Probiotic Mixture and Development of Allergic Sensitization up to 13 
      Years of Age.
PG  - 270-277
LID - 10.1159/000504915 [doi]
AB  - BACKGROUND: Probiotics have shown promising results in primary prevention of 
      allergies in early years, but the long-term effects on allergic sensitization 
      need more evaluation. OBJECTIVES: We conducted a randomized double-blind 
      placebo-controlled study to determine whether the use of a mixture of pre- and 
      probiotics perinatally affects the prevalence of immunoglobulin E (IgE) 
      sensitization up to 13 years in high-risk children. METHODS: One thousand two 
      hundred twenty-three pregnant women were randomized to receiving probiotics or 
      placebo from 36 gestational weeks until delivery, and their infants received pre- 
      and probiotics or placebo from birth until 6 months. At 2, 5, and 13 years, blood 
      samples were taken to determine specific IgE levels against common foods, pollen, 
      and animal antigens. RESULTS: The prevalence of IgE sensitization to any allergen 
      was high and increased with age. No significant difference in the prevalence of 
      IgE sensitization to any particular one of the tested allergens was found between 
      the groups. At 2, 5, and 13 years these prevalence rates of IgE sensitization to 
      any allergen were 31.1 and 34.1%, 50.1 and 45.6%, and 61.4 and 56.8% in the 
      probiotic and placebo groups, respectively. At 13 years, IgE sensitization to 
      cat/dog dander was more frequent in the probiotic group compared to the placebo 
      group (40.2 vs. 31.0%, p = 0.03). CONCLUSIONS: In high-risk children, perinatal 
      use of a mixture of probiotics did not affect the prevalence of sensitization to 
      any one of the tested allergens, but it was associated with more frequent IgE 
      sensitization to cat/dog dander at 13 years.
CI  - (c) 2020 S. Karger AG, Basel.
FAU - Peldan, Paivi Susanna
AU  - Peldan PS
AD  - Pediatric Research Center, University of Helsinki and Helsinki University 
      Hospital, New Children's Hospital, Helsinki, Finland, paivi.peldan@hus.fi.
FAU - Kukkonen, Anna Kaarina
AU  - Kukkonen AK
AD  - Skin and Allergy Hospital, University of Helsinki and Helsinki University 
      Hospital, Helsinki, Finland.
FAU - Savilahti, Erkki
AU  - Savilahti E
AD  - Pediatric Research Center, University of Helsinki and Helsinki University 
      Hospital, New Children's Hospital, Helsinki, Finland.
FAU - Kuitunen, Mikael
AU  - Kuitunen M
AD  - Pediatric Research Center, University of Helsinki and Helsinki University 
      Hospital, New Children's Hospital, Helsinki, Finland.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20200204
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Allergens/*immunology
MH  - Animals
MH  - Cats
MH  - Child, Preschool
MH  - Dogs
MH  - Double-Blind Method
MH  - Female
MH  - Food Hypersensitivity/immunology
MH  - Humans
MH  - Hypersensitivity/*immunology
MH  - Immunoglobulin E/immunology
MH  - Male
MH  - Probiotics/*adverse effects
OTO - NOTNLM
OT  - Allergy prevention
OT  - Clinical trial
OT  - Probiotics
OT  - Sensitization
EDAT- 2020/02/06 06:00
MHDA- 2020/08/08 06:00
CRDT- 2020/02/05 06:00
PHST- 2018/11/09 00:00 [received]
PHST- 2019/11/20 00:00 [accepted]
PHST- 2020/02/06 06:00 [pubmed]
PHST- 2020/08/08 06:00 [medline]
PHST- 2020/02/05 06:00 [entrez]
AID - 000504915 [pii]
AID - 10.1159/000504915 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2020;181(4):270-277. doi: 10.1159/000504915. Epub 2020 
      Feb 4.