PMID- 32018270
OWN - NLM
STAT- MEDLINE
DCOM- 20200930
LR  - 20200930
IS  - 1421-9751 (Electronic)
IS  - 0008-6312 (Linking)
VI  - 145
IP  - 5
DP  - 2020
TI  - Early Repolarization Pattern and Left Ventricular Mass in Hypertrophic 
      Cardiomyopathy.
PG  - 303-308
LID - 10.1159/000505639 [doi]
AB  - BACKGROUND: J-point elevation in the inferior and/or lateral leads is associated 
      with an increased incidence of sudden cardiac death (SCD) in hypertrophic 
      cardiomyopathy (HCM), although the exact underlying mechanism is not known. As 
      severe left ventricular hypertrophy and late gadolinium enhancement (LGE) are 
      important risk factors for SCD in this population, we aimed to assess whether 
      there was an association between an early repolarization pattern (ERP) and 
      greater left ventricular mass (LVM) and LGE extent among patients with HCM. 
      METHODS: This was a retrospective cohort study of 85 consecutive patients with 
      HCM who underwent cardiac magnetic resonance (CMR) and had an electrocardiogram 
      without confounders (intraventricular conduction delay, complete left or right 
      bundle branch block, or ventricular paced rhythm). Baseline characteristics and 
      MRI-derived LVM and LGE extent were compared between patients with and without 
      ERP. RESULTS: ERP was present in 9 out of 85 patients (10.6%). Patients with ERP 
      had greater indexed LVM compared to those without (112.5 +/- 26.3 vs. 87.8 +/- 24.6 
      g/m2, p = 0.006). Logistic regression analysis revealed a 4.2-fold increase in 
      the odds of prevalent ERP per standard deviation increase in body surface 
      area-indexed LVM (odds ratio 4.2; 95% CI 1.54-11.4, p = 0.005). There were no 
      statistically significant differences regarding LGE extent between groups. 
      CONCLUSION: ERP is associated with greater CMR-derived LVM among patients with 
      HCM. This finding could partially explain the association between J waves and a 
      higher risk of SCD in this population. There were no differences in LGE extent. 
      Further studies are needed to confirm this association and evaluate the 
      importance of ERP as a marker of increased risk of SCD in HCM.
CI  - (c) 2020 S. Karger AG, Basel.
FAU - Azevedo, Pedro Miguel Oliveira
AU  - Azevedo PMO
AD  - Cardiology Department, Centro Hospitalar e Universitario do Algarve, Faro, 
      Portugal, pmazevedo@chalgarve.min-saude.pt.
AD  - Algarve Biomedical Center, Faro, Portugal, pmazevedo@chalgarve.min-saude.pt.
FAU - Guerreiro, Claudio
AU  - Guerreiro C
AD  - Cardiology Department, Centro Hospitalar Vila Nova de Gaia/Espinho, Vila Nova de 
      Gaia, Portugal.
FAU - Ladeiras-Lopes, Ricardo
AU  - Ladeiras-Lopes R
AD  - Cardiology Department, Centro Hospitalar Vila Nova de Gaia/Espinho, Vila Nova de 
      Gaia, Portugal.
FAU - Ferreira, Nuno
AU  - Ferreira N
AD  - Cardiology Department, Centro Hospitalar Vila Nova de Gaia/Espinho, Vila Nova de 
      Gaia, Portugal.
FAU - Faria, Rita
AU  - Faria R
AD  - Cardiology Department, Centro Hospitalar Vila Nova de Gaia/Espinho, Vila Nova de 
      Gaia, Portugal.
FAU - Barbosa, Raquel
AU  - Barbosa R
AD  - Cardiology Department, Centro Hospitalar Vila Nova de Gaia/Espinho, Vila Nova de 
      Gaia, Portugal.
FAU - Primo, Joao
AU  - Primo J
AD  - Cardiology Department, Centro Hospitalar Vila Nova de Gaia/Espinho, Vila Nova de 
      Gaia, Portugal.
FAU - Braga, Jose
AU  - Braga J
AD  - Cardiology Department, Centro Hospitalar Vila Nova de Gaia/Espinho, Vila Nova de 
      Gaia, Portugal.
LA  - eng
PT  - Journal Article
DEP - 20200204
PL  - Switzerland
TA  - Cardiology
JT  - Cardiology
JID - 1266406
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
CIN - Cardiology. 2020;145(5):309-310. PMID: 32200372
MH  - Adult
MH  - Aged
MH  - Cardiomyopathy, Hypertrophic/complications/*diagnostic imaging/pathology
MH  - Contrast Media
MH  - Death, Sudden, Cardiac/*etiology
MH  - Electrocardiography
MH  - Female
MH  - Fibrosis
MH  - Gadolinium
MH  - Heart/diagnostic imaging
MH  - Humans
MH  - Logistic Models
MH  - Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Predictive Value of Tests
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - Early repolarization
OT  - Electrocardiogram
OT  - Hypertrophic cardiomyopathy
OT  - Left ventricular mass
OT  - Magnetic resonance imaging
EDAT- 2020/02/06 06:00
MHDA- 2020/10/02 06:00
CRDT- 2020/02/05 06:00
PHST- 2019/10/28 00:00 [received]
PHST- 2019/12/18 00:00 [accepted]
PHST- 2020/02/06 06:00 [pubmed]
PHST- 2020/10/02 06:00 [medline]
PHST- 2020/02/05 06:00 [entrez]
AID - 000505639 [pii]
AID - 10.1159/000505639 [doi]
PST - ppublish
SO  - Cardiology. 2020;145(5):303-308. doi: 10.1159/000505639. Epub 2020 Feb 4.