PMID- 32018341
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2233-6834 (Print)
IS  - 2233-6842 (Electronic)
IS  - 2233-6834 (Linking)
VI  - 23
IP  - 4
DP  - 2019 Dec 31
TI  - Polygonum cuspidatum stem extract (PSE) ameliorates dry eye disease by inhibiting 
      inflammation and apoptosis.
PG  - 14-22
LID - 10.20463/jenb.2019.0026 [doi]
AB  - PURPOSE: Here, we aimed to determine the effect of Polygonum cuspidatum stem 
      extract (PSE) on exorbital lacrimal gland-excised rat models and hyperosmotic 
      stress-stimulated human conjunctival cells (HCCs). METHODS: Seven week old male 
      Wistar rats were divided into six groups. Only the rats in the control group 
      (NOR, n=5) did not undergo surgery. Three days after the surgery, the exorbital 
      lacrimal gland-excised rats were randomly allocated to five groups: (1) 
      vehicle-treated dry-eyed rats (DED, n=5); (2) PSE (10 mg/kg) treated DED rats 
      (PSE-10, n=5); (3) PSE (100 mg/kg) treated DED rats (PSE-100, n=5); and (4) PSE 
      (250 mg/kg) treated DED rats (PSE-250, n=5). In addition, the HCC line was 
      co-treated with hyperosmolar media (528 mOsm) and PSE (1-100 mug/ml). RESULTS: PSE 
      treatment restored the tear volume and goblet cell density by inhibiting severe 
      corneal irregularities and damage. The treatment with PSE significantly 
      attenuated the hyperosmolar stress-induced inflammation and cell death through 
      the suppression of mRNA expression levels of Tumor necrosis factor-alpha (TNF-alpha), 
      Interleukin-6 (IL-6), Interleukin-1beta (IL-1beta), and Interferon-gamma (IFN-gamma), and the 
      expression of Bcl-2-associated X protein (Bax) as well as the activation of 
      caspase-3 in vitro. CONCLUSION: The inhibitory effects of PSE treatment on dry 
      eye disease indicate the potential of nutritional intervention by PES against 
      inflammatory diseases without adverse effects.
CI  - (c)2019 The Korean Society for Exercise Nutrition.
FAU - Park, Bongkyun
AU  - Park B
FAU - Jo, Kyuhyung
AU  - Jo K
FAU - Lee, Tae Gu
AU  - Lee TG
FAU - Lee, Ik Soo
AU  - Lee IS
FAU - Kim, Jin Sook
AU  - Kim JS
FAU - Kim, Chan-Sik
AU  - Kim CS
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - J Exerc Nutrition Biochem
JT  - Journal of exercise nutrition & biochemistry
JID - 101572566
PMC - PMC7004570
OTO - NOTNLM
OT  - Polygonum cuspidatum
EDAT- 2020/02/06 06:00
MHDA- 2020/02/06 06:01
PMCR- 2019/12/31
CRDT- 2020/02/05 06:00
PHST- 2019/10/31 00:00 [received]
PHST- 2019/12/12 00:00 [accepted]
PHST- 2020/02/05 06:00 [entrez]
PHST- 2020/02/06 06:00 [pubmed]
PHST- 2020/02/06 06:01 [medline]
PHST- 2019/12/31 00:00 [pmc-release]
AID - JENB_2019_v23n4 [pii]
AID - JENB_2019_v23n4_14 [pii]
AID - 10.20463/jenb.2019.0026 [doi]
PST - ppublish
SO  - J Exerc Nutrition Biochem. 2019 Dec 31;23(4):14-22. doi: 10.20463/jenb.2019.0026.