PMID- 32021155
OWN - NLM
STAT- MEDLINE
DCOM- 20210216
LR  - 20210216
IS  - 1178-2005 (Electronic)
IS  - 1176-9106 (Print)
IS  - 1176-9106 (Linking)
VI  - 15
DP  - 2020
TI  - Relationships Between Forced Oscillatory Impedance and 6-minute Walk Distance 
      After Pulmonary Rehabilitation in COPD.
PG  - 157-166
LID - 10.2147/COPD.S225543 [doi]
AB  - RATIONALE: Pulmonary rehabilitation for chronic obstructive pulmonary disease 
      (COPD) reduces dyspnoea and improves exercise capacity and quality of life. The 
      improvement in exercise capacity is variable and unpredictable, however. 
      Respiratory system impedance obtained by forced oscillation technique (FOT) as a 
      measure of ventilatory impairment in COPD may relate to improvement in exercise 
      capacity with pulmonary rehabilitation. We aimed to determine if baseline FOT 
      parameters relate to changes in exercise capacity following pulmonary 
      rehabilitation. METHODS: At the start of rehabilitation, 15 COPD subjects 
      (mean(SD) 75.2(6.1) years, FEV1 z-score -2.61(0.84)) had measurements by FOT, 
      spirometry, plethysmographic lung volumes and 6-minute walk distance (6MWD). 
      Respiratory system resistance (Rrs) and reactance (Xrs) parameters as the mean 
      over all breaths (R(mean), X(mean)), during inspiration only (R(insp), X(insp)), 
      and expiratory flow limitation (DeltaXrs = X(insp)-X(exp)), were calculated. FOT 
      and 6MWD measurements were repeated at completion of rehabilitation and 3 months 
      after completion. RESULTS: At baseline, Xrs measures were unrelated to 6MWD. 
      X(insp) improved significantly with rehabilitation (from mean(SD) -2.35(1.02) to 
      -2.04(0.85) cmH(2)O.s.L(-1), p=0.008), while other FOT parameters did not. No FOT 
      parameters related to the change in 6MWD at program completion. Baseline X(mean,) 
      DeltaXrs, and FVC z-score correlated with the change in 6MWD between completion 
      and 3 months after completion of rehabilitation (r(s)=0.62, p=0.03; r(s)=-0.65, 
      p=0.02; and r(s)=0.62, p=0.03, respectively); with worse ventilatory impairment 
      predicting loss of 6MWD. There were no relationships between Rrs parameters, FEV1 
      or FEV1/FVC z-scores and changes in 6MWD. CONCLUSION: Baseline reactance 
      parameters may be helpful in predicting those patients with COPD at most risk of 
      loss of exercise capacity following completion of pulmonary rehabilitation.
CI  - (c) 2020 Zimmermann et al.
FAU - Zimmermann, Sabine C
AU  - Zimmermann SC
AUID- ORCID: 0000-0002-0658-9552
AD  - The Woolcock Emphysema Centre, Woolcock Institute of Medical Research, The 
      University of Sydney, Glebe, NSW 2037, Australia.
AD  - The Northern Clinical School, Faculty of Medicine and Health Sciences, The 
      University of Sydney, Camperdown, NSW 2006, Australia.
AD  - Department of Respiratory Medicine, Royal North Shore Hospital, St Leonards, NSW 
      2065, Australia.
FAU - Thamrin, Cindy
AU  - Thamrin C
AUID- ORCID: 0000-0003-3284-3558
AD  - The Woolcock Emphysema Centre, Woolcock Institute of Medical Research, The 
      University of Sydney, Glebe, NSW 2037, Australia.
FAU - Chan, Andrew Sl
AU  - Chan AS
AUID- ORCID: 0000-0003-2559-3706
AD  - The Northern Clinical School, Faculty of Medicine and Health Sciences, The 
      University of Sydney, Camperdown, NSW 2006, Australia.
AD  - Department of Respiratory Medicine, Royal North Shore Hospital, St Leonards, NSW 
      2065, Australia.
FAU - Bertolin, Amy
AU  - Bertolin A
AD  - The Woolcock Emphysema Centre, Woolcock Institute of Medical Research, The 
      University of Sydney, Glebe, NSW 2037, Australia.
FAU - Chapman, David G
AU  - Chapman DG
AUID- ORCID: 0000-0002-8211-1817
AD  - The Woolcock Emphysema Centre, Woolcock Institute of Medical Research, The 
      University of Sydney, Glebe, NSW 2037, Australia.
AD  - School of Life Sciences, Faculty of Science, University of Technology Sydney, 
      Ultimo, NSW 2007, Australia.
FAU - King, Gregory G
AU  - King GG
AD  - The Woolcock Emphysema Centre, Woolcock Institute of Medical Research, The 
      University of Sydney, Glebe, NSW 2037, Australia.
AD  - The Northern Clinical School, Faculty of Medicine and Health Sciences, The 
      University of Sydney, Camperdown, NSW 2006, Australia.
AD  - Department of Respiratory Medicine, Royal North Shore Hospital, St Leonards, NSW 
      2065, Australia.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Observational Study
DEP - 20200121
PL  - New Zealand
TA  - Int J Chron Obstruct Pulmon Dis
JT  - International journal of chronic obstructive pulmonary disease
JID - 101273481
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Exercise Tolerance
MH  - Female
MH  - Forced Expiratory Volume
MH  - Humans
MH  - Lung/*physiopathology
MH  - Male
MH  - Oscillometry
MH  - Pilot Projects
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Pulmonary Disease, Chronic Obstructive/diagnosis/physiopathology/*rehabilitation
MH  - Recovery of Function
MH  - *Respiratory Function Tests
MH  - Time Factors
MH  - Treatment Outcome
MH  - Vital Capacity
MH  - *Walk Test
PMC - PMC6982450
OTO - NOTNLM
OT  - COPD
OT  - forced oscillation technique
OT  - pulmonary rehabilitation
OT  - quality of life
OT  - reactance
OT  - six-minute walk test
COIS- Dr Sabine C Zimmermann was supported by the National Health and Medical Research 
      (NHMRC) Postgraduate Scholarship, during the conduct of the study; non-financial 
      support from Boehringer Ingelheim, Glaxo Smith Kline, Astra Zeneca, Novartis, and 
      Menarini, outside the submitted work. Dr Cindy Thamrin reports a patent WO 
      2006130922 A1 issued; and has intellectual property arrangements with THORASYS 
      Thoracic Medical Systems Inc and Restech srl relating to scientific 
      collaborations, but does not have any financial relationships with either 
      company. She is also a member of a current international committee on FOT 
      technical standards. Prof. Dr. Gregory King reports grants from NHMRC, 
      non-financial support from Restech, during the conduct of the study; personal 
      fees from Pharmaceutical Industry, GSK, and grants from CycloPharma, outside the 
      submitted work. The authors report no other conflicts of interest in this work.
EDAT- 2020/02/06 06:00
MHDA- 2021/02/17 06:00
PMCR- 2020/01/21
CRDT- 2020/02/06 06:00
PHST- 2019/07/31 00:00 [received]
PHST- 2019/12/19 00:00 [accepted]
PHST- 2020/02/06 06:00 [entrez]
PHST- 2020/02/06 06:00 [pubmed]
PHST- 2021/02/17 06:00 [medline]
PHST- 2020/01/21 00:00 [pmc-release]
AID - 225543 [pii]
AID - 10.2147/COPD.S225543 [doi]
PST - epublish
SO  - Int J Chron Obstruct Pulmon Dis. 2020 Jan 21;15:157-166. doi: 
      10.2147/COPD.S225543. eCollection 2020.