PMID- 32021183
OWN - NLM
STAT- MEDLINE
DCOM- 20200518
LR  - 20240328
IS  - 1178-2013 (Electronic)
IS  - 1176-9114 (Print)
IS  - 1176-9114 (Linking)
VI  - 15
DP  - 2020
TI  - Incorporation of ROS-Responsive Substance P-Loaded Zeolite Imidazolate 
      Framework-8 Nanoparticles into a Ca(2+)-Cross-Linked Alginate/Pectin Hydrogel for 
      Wound Dressing Applications.
PG  - 333-346
LID - 10.2147/IJN.S225197 [doi]
AB  - PURPOSE: Wound healing, especially of extensive full-thickness wounds, is one of 
      the most difficult problems in clinical studies. In this study, we prepared a 
      novel substance P (SP)-delivery system using zeolite imidazolate framework-8 
      (ZIF-8) nanoparticles. METHODS: We synthesized ZIF-8 nanoparticles using a 
      modified biomimetic mineralization method. We then coated SP-loaded ZIF-8 
      nanoparticles (SP@ZIF-8) with polyethylene glycol-thioketal (PEG-TK) to fabricate 
      SP@ZIF-8-PEG-TK nanoparticles, and encapsulated them in injectable hydrogel 
      composed of sodium alginate and pectin and cross-linked using calcium chloride. 
      The final hydrogel wound dressing containing SP@ZIF-8-PEG-TK nanoparticles was 
      called SP@ZIF-8-PEG-TK@CA. RESULTS: The fabricated ZIF-8 nanoparticles had high 
      SP-loading efficiency. SP-release assay showed that the SP@ZIF-8-PEG-TK 
      nanoparticles maintained drug activity and showed responsive release under 
      stimulation by reactive oxygen species. The SP@ZIF-8-PEG-TK nanoparticles 
      promoted proliferation of human dermal fibroblasts, up-regulated expression 
      levels of inflammation-related genes in macrophages, and exhibited favorable 
      cytocompatibility in vitro. Full-thickness excision wound models in vivo 
      confirmed that SP@ZIF-8-PEG-TK@CA dressings had excellent wound-healing efficacy 
      by promoting an early inflammatory response and subsequent M2 macrophage 
      polarization in the wound-healing process. CONCLUSION: In conclusion, these 
      findings indicated that SP@ZIF-8-PEG-TK@CA dressings might be useful for wound 
      dressing applications in the clinic.
CI  - (c) 2020 Zhu et al.
FAU - Zhu, Yiming
AU  - Zhu Y
AD  - Department of General Surgery, Shanghai Ninth People's Hospital, School of 
      Medicine, Shanghai Jiao Tong University, Huangpu, Shanghai, China.
FAU - Yao, Zuochao
AU  - Yao Z
AD  - Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's 
      Hospital, School of Medicine, Shanghai Jiao Tong University, Huangpu, Shanghai, 
      China.
FAU - Liu, Yushu
AU  - Liu Y
AD  - Department of Burns and Plastic Surgery, Binzhou Medical University Hospital, 
      Binzhou City, Shandong Province, China.
FAU - Zhang, Wen
AU  - Zhang W
AD  - Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's 
      Hospital, School of Medicine, Shanghai Jiao Tong University, Huangpu, Shanghai, 
      China.
FAU - Geng, Lele
AU  - Geng L
AUID- ORCID: 0000-0002-0165-7675
AD  - Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's 
      Hospital, School of Medicine, Shanghai Jiao Tong University, Huangpu, Shanghai, 
      China.
FAU - Ni, Tao
AU  - Ni T
AD  - Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's 
      Hospital, School of Medicine, Shanghai Jiao Tong University, Huangpu, Shanghai, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20200120
PL  - New Zealand
TA  - Int J Nanomedicine
JT  - International journal of nanomedicine
JID - 101263847
RN  - 0 (Alginates)
RN  - 0 (Cross-Linking Reagents)
RN  - 0 (Hydrogels)
RN  - 0 (Imidazoles)
RN  - 0 (Reactive Oxygen Species)
RN  - 1318-02-1 (Zeolites)
RN  - 33507-63-0 (Substance P)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 89NA02M4RX (Pectins)
RN  - M4I0D6VV5M (Calcium Chloride)
SB  - IM
MH  - Alginates/chemistry
MH  - Animals
MH  - *Bandages
MH  - Calcium Chloride/chemistry
MH  - Cell Proliferation/drug effects
MH  - Cross-Linking Reagents/chemistry
MH  - Drug Delivery Systems/methods
MH  - Fibroblasts/cytology/drug effects
MH  - Humans
MH  - Hydrogels/chemistry
MH  - Imidazoles/chemistry
MH  - Mice, Inbred BALB C
MH  - Nanoparticles/administration & dosage/*chemistry
MH  - Pectins/chemistry
MH  - Polyethylene Glycols/chemistry
MH  - Reactive Oxygen Species/*metabolism
MH  - Substance P/*administration & dosage/pharmacokinetics
MH  - Wound Healing/*drug effects
MH  - Zeolites/*chemistry
PMC - PMC6980861
OTO - NOTNLM
OT  - hydrogel
OT  - metal-organic framework
OT  - nanoparticles
OT  - substance P
OT  - wound healing
COIS- The authors declared that they have no competing interests.
EDAT- 2020/02/06 06:00
MHDA- 2020/05/19 06:00
PMCR- 2020/01/20
CRDT- 2020/02/06 06:00
PHST- 2019/07/29 00:00 [received]
PHST- 2020/01/02 00:00 [accepted]
PHST- 2020/02/06 06:00 [entrez]
PHST- 2020/02/06 06:00 [pubmed]
PHST- 2020/05/19 06:00 [medline]
PHST- 2020/01/20 00:00 [pmc-release]
AID - 225197 [pii]
AID - 10.2147/IJN.S225197 [doi]
PST - epublish
SO  - Int J Nanomedicine. 2020 Jan 20;15:333-346. doi: 10.2147/IJN.S225197. eCollection 
      2020.