PMID- 32021341
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220412
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 12
DP  - 2019
TI  - The effects of ginger supplementation on inflammatory, antioxidant, and 
      periodontal parameters in type 2 diabetes mellitus patients with chronic 
      periodontitis under non-surgical periodontal therapy. A double-blind, 
      placebo-controlled trial.
PG  - 1751-1761
LID - 10.2147/DMSO.S214333 [doi]
AB  - BACKGROUND: The aim of this study was to evaluate the effects of ginger 
      supplementation on inflammatory, antioxidant, and periodontal parameters in type 
      2 diabetes mellitus (T2DM) patients with chronic periodontitis (CP) under 
      non-surgical periodontal therapy (NSPT). MATERIAL AND METHODS: In this 
      double-blind clinical trial study, 46 T2DM patients with CP were randomly 
      allocated to intervention and control groups and received either 4 tablets 500 mg 
      (2 g) ginger or placebo twice a day for 8 weeks. All patients were treated with 
      NSPT during the intervention period. Serum levels of tumor necrosis factor-alpha 
      (TNF-alpha), interleukin-6 (IL-6), hs-C-reactive protein (hs-CRP), superoxide 
      dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), periodontal 
      indices including clinical attachment loss (CAL), bleeding on probing (BOP), 
      pocket depth (PD), and plaque index were evaluated in all subjects pre- and 
      post-intervention. RESULTS: Following 8 weeks of ginger treatment with NSPT, 
      significant reductions were observed in the mean levels of IL-6 (p=0.001), hs-CRP 
      (p=0.03), TNF-alpha (p=0.007), CAL, and PD (p<0.001) in the intervention group. The 
      mean serum levels of SOD and GPx were significantly increased in the intervention 
      group after the intervention (p=0.001 and 0.002, respectively). At the end of the 
      study, the mean changes of GPx were significantly higher in the intervention 
      group compared with the control group (p=0.04). Also, after the administration of 
      the ginger with NSPT, significant decrease occurred in the mean change of IL-6 
      (p=0.009), hs-CRP (p=0.049), TNF-alpha (p=0.049), CAL (p=0.003), and PD (p=0.04) 
      compared with the control group. CONCLUSION: It is recommended that ginger 
      supplementation along with NSPT may be effective in the improvement of 
      inflammation, oxidative, and periodontal status in T2DM with CP.
CI  - (c) 2019 Zare Javid et al.
FAU - Zare Javid, Ahmad
AU  - Zare Javid A
AD  - Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of 
      Medical Sciences, Ahvaz, Iran.
AD  - Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur 
      University of Medical Sciences, Ahvaz, Iran.
FAU - Bazyar, Hadi
AU  - Bazyar H
AD  - Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur 
      University of Medical Sciences, Ahvaz, Iran.
AD  - Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, 
      Ahvaz, Iran.
FAU - Gholinezhad, Hasan
AU  - Gholinezhad H
AD  - Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur 
      University of Medical Sciences, Ahvaz, Iran.
FAU - Rahimlou, Mehran
AU  - Rahimlou M
AD  - Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur 
      University of Medical Sciences, Ahvaz, Iran.
FAU - Rashidi, Homeira
AU  - Rashidi H
AD  - Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University 
      of Medical Sciences, Ahvaz, Iran.
FAU - Salehi, Parvin
AU  - Salehi P
AD  - Department of Periodontology, School of Dentistry, Ahvaz Jundishapur University 
      of Medical Sciences, Ahvaz, Iran.
FAU - Haghighi-Zadeh, Mohammad Hosein
AU  - Haghighi-Zadeh MH
AD  - Department of Biostatistics, School of Public Health, Ahvaz Jundishapur 
      University of Medical Sciences, Ahvaz, Iran.
LA  - eng
PT  - Journal Article
DEP - 20190906
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC6737165
OTO - NOTNLM
OT  - antioxidant enzymes
OT  - ginger
OT  - inflammation
OT  - periodontal disease
OT  - type 2 diabetes mellitus
COIS- The authors report no conflicts of interest in this work.
EDAT- 2020/02/06 06:00
MHDA- 2020/02/06 06:01
PMCR- 2019/09/06
CRDT- 2020/02/06 06:00
PHST- 2019/05/08 00:00 [received]
PHST- 2019/08/17 00:00 [accepted]
PHST- 2020/02/06 06:00 [entrez]
PHST- 2020/02/06 06:00 [pubmed]
PHST- 2020/02/06 06:01 [medline]
PHST- 2019/09/06 00:00 [pmc-release]
AID - 214333 [pii]
AID - 10.2147/DMSO.S214333 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2019 Sep 6;12:1751-1761. doi: 10.2147/DMSO.S214333. 
      eCollection 2019.