PMID- 32021496
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1179-1470 (Print)
IS  - 1179-1470 (Electronic)
IS  - 1179-1470 (Linking)
VI  - 13
DP  - 2020
TI  - The AngelMed Guardian((R)) System in the Detection of Coronary Artery Occlusion: 
      Current Perspectives.
PG  - 1-12
LID - 10.2147/MDER.S219865 [doi]
AB  - Total ischemic time, which specifies the time from the onset of chest pain to 
      initiation of reperfusion during percutaneous coronary intervention, consists of 
      two intervals: symptom to door time and door to balloon time. A door to balloon 
      time of 90 mins or less has become a quality-of-care metric in the management of 
      ST elevation myocardial infarction (STEMI). While national efforts made by the 
      American College of Cardiology (ACC) and American Heart Association (AHA) have 
      curtailed in-hospital door to balloon time over the years, a reduction in 
      pre-hospital symptoms to door time presents a challenge in modern interventional 
      Cardiology. Early and complete revascularization has been associated with 
      improved clinical outcomes in MI and strategies that may help reduce symptom to 
      door time, and thus the total ischemic time, are crucial. Rapidly evolving 
      ST-segment changes commonly develop prior to ischemia-related symptom onset, and 
      are detectable even in patients with clinically unrecognized silent MIs. 
      Therefore, a highly intelligent ischemia detection system that alerts patients of 
      ST segment deviation may allow for rapid identification of acute coronary 
      occlusion. The AngelMed Guardian((R)) System is a cardiac activity monitoring and 
      alerting system designed for rapid identification of intracardiac ST-segment 
      changes among patients at a high risk for recurrent ACS events. This article 
      reviews the clinical studies evaluating the design, safety and efficacy of the 
      AngelMed Guardian System and discusses the clinical implications of the device.
CI  - (c) 2020 Kazmi et al.
FAU - Kazmi, Syed Hassan Abbas
AU  - Kazmi SHA
AD  - Division of Cardiovascular Medicine, Department of Medicine, Beth Israel 
      Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
FAU - Datta, Sudarshana
AU  - Datta S
AUID- ORCID: 0000-0002-7714-9802
AD  - Division of Cardiovascular Medicine, Department of Medicine, Beth Israel 
      Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
FAU - Chi, Gerald
AU  - Chi G
AUID- ORCID: 0000-0002-8371-1689
AD  - Division of Cardiovascular Medicine, Department of Medicine, Beth Israel 
      Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
FAU - Nafee, Tarek
AU  - Nafee T
AD  - Division of Cardiovascular Medicine, Department of Medicine, Beth Israel 
      Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
FAU - Yee, Megan
AU  - Yee M
AD  - Division of Cardiovascular Medicine, Department of Medicine, Beth Israel 
      Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
FAU - Kalia, Akshun
AU  - Kalia A
AUID- ORCID: 0000-0003-3379-9587
AD  - Division of Cardiovascular Medicine, Department of Medicine, Beth Israel 
      Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
FAU - Sharfaei, Sadaf
AU  - Sharfaei S
AUID- ORCID: 0000-0002-6351-6253
AD  - Division of Cardiovascular Medicine, Department of Medicine, Beth Israel 
      Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
FAU - Shojaei, Fahimehalsadat
AU  - Shojaei F
AD  - Division of Cardiovascular Medicine, Department of Medicine, Beth Israel 
      Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
FAU - Mirwais, Sabawoon
AU  - Mirwais S
AD  - Division of Cardiovascular Medicine, Department of Medicine, Beth Israel 
      Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
FAU - Gibson, C Michael
AU  - Gibson CM
AD  - Division of Cardiovascular Medicine, Department of Medicine, Beth Israel 
      Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200107
PL  - New Zealand
TA  - Med Devices (Auckl)
JT  - Medical devices (Auckland, N.Z.)
JID - 101566041
PMC - PMC6954830
OTO - NOTNLM
OT  - ST elevation myocardial infarction
OT  - acute coronary syndrome
OT  - electrocardiography
OT  - ischemia monitoring
OT  - myocardial infarction
COIS- Dr C. Michael Gibson reports grants, personal fees from Angel Medical, during the 
      conduct of the study. The authors report no other conflicts of interest in this 
      work.
EDAT- 2020/02/06 06:00
MHDA- 2020/02/06 06:01
PMCR- 2020/01/07
CRDT- 2020/02/06 06:00
PHST- 2019/06/18 00:00 [received]
PHST- 2019/12/13 00:00 [accepted]
PHST- 2020/02/06 06:00 [entrez]
PHST- 2020/02/06 06:00 [pubmed]
PHST- 2020/02/06 06:01 [medline]
PHST- 2020/01/07 00:00 [pmc-release]
AID - 219865 [pii]
AID - 10.2147/MDER.S219865 [doi]
PST - epublish
SO  - Med Devices (Auckl). 2020 Jan 7;13:1-12. doi: 10.2147/MDER.S219865. eCollection 
      2020.