PMID- 32021905
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220412
IS  - 2352-9067 (Print)
IS  - 2352-9067 (Electronic)
IS  - 2352-9067 (Linking)
VI  - 26
DP  - 2020 Feb
TI  - Correlation between septal midwall late gadolinium enhancement on CMR and 
      conduction delay on ECG in patients with nonischemic dilated cardiomyopathy.
PG  - 100474
LID - 10.1016/j.ijcha.2020.100474 [doi]
LID - 100474
AB  - BACKGROUND: Septal midwall late gadolinium enhancement (LGE) on cardiac magnetic 
      resonance imaging (CMR) is a characteristic finding in nonischemic dilated 
      cardiomyopathy (DCM) and is associated with adverse cardiac events. 
      QRS-prolongation in DCM is also frequently present and a predictor of arrhythmic 
      events and mortality. Since the His-Purkinje fibres are located in the 
      interventricular septum, QRS-prolongation may directly result from septal 
      fibrosis, visualized by LGE. Our aim was to study the correlation of the presence 
      and extent of septal midwall LGE and QRS-duration. METHODS: DCM-patients with 
      left ventricular (LV) dysfunction (LVEF < 50%) were included. LV volumes, 
      systolic function and nonischemic septal midwall LGE, defined as patchy or 
      stripe-like LGE in the septal segments, were quantified. QRS-duration on standard 
      12-lead ECG was measured. RESULTS: 165 DCM-patients were included (62% male, mean 
      age 59 +/- 15 years) with a median LVEF of 36% [24-44]. Fifty-one patients (31%) 
      demonstrated septal midwall LGE with a median extent of 8.1 gram [4.3-16.8]. 
      Patients with midwall LGE had increased LV end-diastolic volumes (EDV) 248 mL 
      [193-301] vs. 193 mL [160-239], p < 0.001) and lower LVEF (26% [18-35] vs. 40% 
      [32-45], p < 0.001). Median QRS-duration was 110 ms [95-146] without a 
      correlation to the presence nor extent of midwall LGE. QRS-duration was 
      moderately correlated with LV-dilation and mass (respectively r = 0.35, p < 0.001 
      and r = 0.30, p < 0.001). CONCLUSION: In DCM-patients, QRS-prolongation and 
      septal midwall LGE are frequently present and often co-exist. However, they are 
      not correlated. This suggests that the assessment of LGE-CMR has complementary 
      value to ECG evaluation in the clinical assessment and risk stratification of 
      DCM-patients.
CI  - (c) 2020 The Authors.
FAU - Becker, Marthe A J
AU  - Becker MAJ
AD  - Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Cardiology, Amsterdam 
      Cardiovascular Sciences, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands.
AD  - North West Hospital Group Alkmaar, Department of Cardiology, Wilhelminalaan 12, 
      1815 JD Alkmaar, the Netherlands.
FAU - Allaart, Cornelis P
AU  - Allaart CP
AD  - Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Cardiology, Amsterdam 
      Cardiovascular Sciences, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands.
FAU - Zweerink, Alwin
AU  - Zweerink A
AD  - Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Cardiology, Amsterdam 
      Cardiovascular Sciences, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands.
FAU - Cornel, Jan H
AU  - Cornel JH
AD  - North West Hospital Group Alkmaar, Department of Cardiology, Wilhelminalaan 12, 
      1815 JD Alkmaar, the Netherlands.
AD  - Radboud University Medical Center, Department of Cardiology, Geert Grooteplein 
      Zuid 10, 6525 GA Nijmegen, the Netherlands.
FAU - van de Ven, Peter M
AU  - van de Ven PM
AD  - Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Epidemiology and 
      Biostatistics, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands.
FAU - van Rossum, Albert C
AU  - van Rossum AC
AD  - Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Cardiology, Amsterdam 
      Cardiovascular Sciences, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands.
FAU - Germans, Tjeerd
AU  - Germans T
AD  - Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Cardiology, Amsterdam 
      Cardiovascular Sciences, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands.
AD  - North West Hospital Group Alkmaar, Department of Cardiology, Wilhelminalaan 12, 
      1815 JD Alkmaar, the Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20200125
PL  - Ireland
TA  - Int J Cardiol Heart Vasc
JT  - International journal of cardiology. Heart & vasculature
JID - 101649525
PMC - PMC6994302
OTO - NOTNLM
OT  - Conduction delay
OT  - Nonischemic dilated cardiomyopathy
OT  - QRS duration
OT  - Septal midwall LGE
COIS- No conflict of interest. No grants or other form of financial support received.
EDAT- 2020/02/06 06:00
MHDA- 2020/02/06 06:01
PMCR- 2020/01/25
CRDT- 2020/02/06 06:00
PHST- 2019/11/20 00:00 [received]
PHST- 2020/01/17 00:00 [revised]
PHST- 2020/01/18 00:00 [accepted]
PHST- 2020/02/06 06:00 [entrez]
PHST- 2020/02/06 06:00 [pubmed]
PHST- 2020/02/06 06:01 [medline]
PHST- 2020/01/25 00:00 [pmc-release]
AID - S2352-9067(20)30018-X [pii]
AID - 100474 [pii]
AID - 10.1016/j.ijcha.2020.100474 [doi]
PST - epublish
SO  - Int J Cardiol Heart Vasc. 2020 Jan 25;26:100474. doi: 
      10.1016/j.ijcha.2020.100474. eCollection 2020 Feb.