PMID- 32023469
OWN - NLM
STAT- MEDLINE
DCOM- 20210316
LR  - 20220423
IS  - 2211-1247 (Electronic)
VI  - 30
IP  - 5
DP  - 2020 Feb 4
TI  - Neonatal Rhesus Macaques Have Distinct Immune Cell Transcriptional Profiles 
      following HIV Envelope Immunization.
PG  - 1553-1569.e6
LID - S2211-1247(19)31756-5 [pii]
LID - 10.1016/j.celrep.2019.12.091 [doi]
AB  - HIV-1-infected infants develop broadly neutralizing antibodies (bnAbs) more 
      rapidly than adults, suggesting differences in the neonatal versus adult 
      responses to the HIV-1 envelope (Env). Here, trimeric forms of HIV-1 Env 
      immunogens elicit increased gp120- and gp41-specific antibodies more rapidly in 
      neonatal macaques than adult macaques. Transcriptome analyses of neonatal versus 
      adult immune cells after Env vaccination reveal that neonatal macaques have 
      higher levels of the apoptosis regulator BCL2 in T cells and lower levels of the 
      immunosuppressive interleukin-10 (IL-10) receptor alpha (IL10RA) mRNA transcripts 
      in T cells, B cells, natural killer (NK) cells, and monocytes. In addition, 
      immunized neonatal macaques exhibit increased frequencies of activated blood T 
      follicular helper-like (Tfh) cells compared to adults. Thus, neonatal macaques 
      have transcriptome signatures of decreased immunosuppression and apoptosis 
      compared with adult macaques, providing an immune landscape conducive to 
      early-life immunization prior to sexual debut.
CI  - Copyright (c) 2020 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Han, Qifeng
AU  - Han Q
AD  - Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, 
      USA.
FAU - Bradley, Todd
AU  - Bradley T
AD  - Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, 
      USA.
FAU - Williams, Wilton B
AU  - Williams WB
AD  - Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, 
      USA.
FAU - Cain, Derek W
AU  - Cain DW
AD  - Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, 
      USA.
FAU - Montefiori, David C
AU  - Montefiori DC
AD  - Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, 
      USA.
FAU - Saunders, Kevin O
AU  - Saunders KO
AD  - Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, 
      USA.
FAU - Parks, Robert J
AU  - Parks RJ
AD  - Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, 
      USA.
FAU - Edwards, Regina W
AU  - Edwards RW
AD  - Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, 
      USA.
FAU - Ferrari, Guido
AU  - Ferrari G
AD  - Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, 
      USA.
FAU - Mueller, Olaf
AU  - Mueller O
AD  - Center for Genomics of Microbial Systems, Duke University Medical Center, Durham, 
      NC, USA.
FAU - Shen, Xiaoying
AU  - Shen X
AD  - Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, 
      USA.
FAU - Wiehe, Kevin J
AU  - Wiehe KJ
AD  - Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, 
      USA.
FAU - Reed, Steven
AU  - Reed S
AD  - IDRI, Seattle, WA, USA.
FAU - Fox, Christopher B
AU  - Fox CB
AD  - IDRI, Seattle, WA, USA.
FAU - Rountree, Wes
AU  - Rountree W
AD  - Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, 
      USA.
FAU - Vandergrift, Nathan A
AU  - Vandergrift NA
AD  - Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, 
      USA.
FAU - Wang, Yunfei
AU  - Wang Y
AD  - Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, 
      USA.
FAU - Sutherland, Laura L
AU  - Sutherland LL
AD  - Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, 
      USA.
FAU - Santra, Sampa
AU  - Santra S
AD  - Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, 
      Harvard Medical School, Boston, MA, USA.
FAU - Moody, M Anthony
AU  - Moody MA
AD  - Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, 
      USA.
FAU - Permar, Sallie R
AU  - Permar SR
AD  - Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, 
      USA.
FAU - Tomaras, Georgia D
AU  - Tomaras GD
AD  - Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, 
      USA.
FAU - Lewis, Mark G
AU  - Lewis MG
AD  - BIOQUAL, Inc., Rockville, MD, USA.
FAU - Van Rompay, Koen K A
AU  - Van Rompay KKA
AD  - California National Primate Research Center, University of California, Davis, 
      Davis, CA, USA.
FAU - Haynes, Barton F
AU  - Haynes BF
AD  - Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, 
      USA. Electronic address: barton.haynes@dm.duke.edu.
LA  - eng
GR  - UM1 AI100645/AI/NIAID NIH HHS/United States
GR  - P51 OD011107/OD/NIH HHS/United States
GR  - R01 AI140897/AI/NIAID NIH HHS/United States
GR  - P01 AI131251/AI/NIAID NIH HHS/United States
GR  - R01 AI120801/AI/NIAID NIH HHS/United States
GR  - P30 AI064518/AI/NIAID NIH HHS/United States
GR  - UM1 AI144371/AI/NIAID NIH HHS/United States
GR  - P40 OD012217/OD/NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PL  - United States
TA  - Cell Rep
JT  - Cell reports
JID - 101573691
RN  - 0 (AIDS Vaccines)
RN  - 0 (Antibodies, Neutralizing)
RN  - 0 (RNA, Messenger)
RN  - 0 (Viral Envelope Proteins)
SB  - IM
MH  - AIDS Vaccines/immunology
MH  - Animals
MH  - Animals, Newborn
MH  - Antibodies, Neutralizing/blood
MH  - Antibody Formation/immunology
MH  - Feces/microbiology
MH  - HIV Infections/blood/immunology
MH  - HIV-1/*immunology
MH  - *Immunization
MH  - Lymphocyte Activation/immunology
MH  - Lymphocyte Subsets/immunology
MH  - Macaca mulatta
MH  - Microbiota
MH  - Monocytes/metabolism
MH  - RNA, Messenger/genetics/metabolism
MH  - T-Lymphocytes, Helper-Inducer/immunology
MH  - *Transcription, Genetic
MH  - Transcriptome/genetics
MH  - Up-Regulation/genetics
MH  - Viral Envelope Proteins/*immunology
PMC - PMC7243677
MID - NIHMS1568955
OTO - NOTNLM
OT  - HIV-1 envelope
OT  - immunization
OT  - neonates
OT  - rhesus macaques
OT  - single-cell RNA sequencing
OT  - transcriptome
COIS- Declaration of Interests B.F.H. and K.O.S. have patent applications for some of 
      the immunogens used in this study.
EDAT- 2020/02/06 06:00
MHDA- 2021/03/17 06:00
PMCR- 2020/05/22
CRDT- 2020/02/06 06:00
PHST- 2019/05/28 00:00 [received]
PHST- 2019/10/16 00:00 [revised]
PHST- 2019/12/24 00:00 [accepted]
PHST- 2020/02/06 06:00 [entrez]
PHST- 2020/02/06 06:00 [pubmed]
PHST- 2021/03/17 06:00 [medline]
PHST- 2020/05/22 00:00 [pmc-release]
AID - S2211-1247(19)31756-5 [pii]
AID - 10.1016/j.celrep.2019.12.091 [doi]
PST - ppublish
SO  - Cell Rep. 2020 Feb 4;30(5):1553-1569.e6. doi: 10.1016/j.celrep.2019.12.091.