PMID- 32023754
OWN - NLM
STAT- MEDLINE
DCOM- 20200213
LR  - 20200717
IS  - 0253-2727 (Print)
IS  - 2707-9740 (Electronic)
IS  - 0253-2727 (Linking)
VI  - 41
IP  - 1
DP  - 2020 Jan 14
TI  - [The prognostic value of baseline serum free light chain in immunoglobulin 
      light-chain cardiac amyloidosis].
PG  - 47-53
LID - 10.3760/cma.j.issn.0253-2727.2020.01.009 [doi]
AB  - Objective: To analyze the prognostic value of baseline serum free light chain 
      (sFLC) in immunoglobulin light-chain cardiac amyloidosis (AL-CA) . Methods: 
      Thirty patients diagnosed with AL-CA from January 2012 to December 2016 at 
      Beijing Chaoyang Hospital were included in this study to retrospectively evaluate 
      the clinical data. The cut-off value of dFLC (involved sFLC minus uninvolved 
      sFLC) was determined according to the receiver operator characteristic curve 
      (ROC) and grouped, the prognoses of both groups were evaluated. Results: The 
      onset age of all AL-CA patients was 57 years old. It occurred more commonly in 
      men (21 cases, 70%) and the light chains of immunoglobulin composed mainly of 
      type lambda (22 cases, 73.3%) . Renal involvements occurred in 17 cases (56.7%) . The 
      median value of difference between involved and uninvolved serum immunoglobulin 
      free light chain levels (dFLC) was 162.9 (57.9-401.6) mg/L. More subjects in the 
      high dFLC group had higher BNP (P=0.005) , and shorter median survival than those 
      in the low dFLC group (15 months vs 47 months, P<0.001) . Similar results of 
      median survival were observed when the patients were redivided by a new cut-off 
      value of 180 mg/L for dFLC (high dFLC group: 22 months, low dFLC group: 40 
      months, P=0.001) , or a kappa/lambda ratio in which patients with kappa type sFLC-ratio<3.79 
      and lambda type sFLC-ratio>/=0.06 were grouped into the low sFLC-ratio (37 months) , and 
      the reverse the high sFLC-ratio ones (25 months, P=0.021) . In multivariate 
      analysis, dFLC and New York Heart Association (NYHA) classification of cardiac 
      function were two risk factors associated with all-cause mortality in patients, 
      of them the hazard ratio for higher dFLC was 12.13 (95%CI 2.98-49.30, P<0.001) . 
      Conclusion: Measurement of the sFLC level could implicate the prognosis of AL-CA.
FAU - Wang, L M
AU  - Wang LM
AD  - Department of Geriatrics, Beijing NO.6 Hospital, Beijing 100007, China.
FAU - Wang, T T
AU  - Wang TT
AD  - Department of Hematology, Beijing Chaoyang Hospital of Capital Medical 
      University, Beijing 100020, China.
FAU - Tian, Y
AU  - Tian Y
AD  - Department of Hematology, Beijing Chaoyang Hospital of Capital Medical 
      University, Beijing 100020, China.
FAU - Zhao, L
AU  - Zhao L
AD  - Department of Cardiology, Beijing Chaoyang Hospital of Capital Medical 
      University, Beijing 100020, China.
FAU - Yang, X C
AU  - Yang XC
AD  - Department of Cardiology, Beijing Chaoyang Hospital of Capital Medical 
      University, Beijing 100020, China.
FAU - Chen, W M
AU  - Chen WM
AD  - Department of Hematology, Beijing Chaoyang Hospital of Capital Medical 
      University, Beijing 100020, China.
LA  - chi
GR  - 2018M641419/China Postdoctoral Fund/
GR  - 2018-22-114/Beijing Postdoctoral Fund Support Project/
PT  - Journal Article
PL  - China
TA  - Zhonghua Xue Ye Xue Za Zhi
JT  - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
JID - 8212398
RN  - 0 (Immunoglobulin Light Chains)
SB  - IM
MH  - Female
MH  - Humans
MH  - Immunoglobulin Light Chains
MH  - *Immunoglobulin Light-chain Amyloidosis
MH  - *Kidney
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Retrospective Studies
PMC - PMC7357907
OTO - NOTNLM
OT  - Amyloidosis
OT  - Myoeardium
OT  - Prognosis
OT  - Serum free light chain
EDAT- 2020/02/07 06:00
MHDA- 2020/02/14 06:00
PMCR- 2020/01/01
CRDT- 2020/02/07 06:00
PHST- 2020/02/07 06:00 [entrez]
PHST- 2020/02/07 06:00 [pubmed]
PHST- 2020/02/14 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - cjh-41-01-047 [pii]
AID - 10.3760/cma.j.issn.0253-2727.2020.01.009 [doi]
PST - ppublish
SO  - Zhonghua Xue Ye Xue Za Zhi. 2020 Jan 14;41(1):47-53. doi: 
      10.3760/cma.j.issn.0253-2727.2020.01.009.