PMID- 3202454
OWN - NLM
STAT- MEDLINE
DCOM- 19890126
LR  - 20071114
IS  - 0003-0805 (Print)
IS  - 0003-0805 (Linking)
VI  - 138
IP  - 4
DP  - 1988 Oct
TI  - Patterns of improvement in spirometry, bronchial hyperresponsiveness, and 
      specific IgE antibody levels after cessation of exposure in occupational asthma 
      caused by snow-crab processing.
PG  - 807-12
AB  - Thirty-one workers with occupational asthma caused by snow-crab processing were 
      assessed by a long-term follow-up on three occasions at mean +/- SD intervals of 
      12.8 +/- 5.4, 31.4 +/- 6.3, and 64.4 +/- 6.3 months after leaving work. The 
      diagnosis of work-related asthma was initially confirmed in all of them by 
      specific inhalation challenges at the workplace or by laboratory inhalation of 
      snow-crab boiling water (n = 24) or by serial monitoring of airway caliber and 
      bronchial responsiveness to histamine at work and off work (n = 7). Total 
      duration of work-related exposure was 12.8 +/- 5.6 months (range, 3 to 21 
      months), and the duration of symptoms after onset was 6.8 +/- 4.2 months (range, 
      1 to 18 months). At the time of diagnosis, all 31 subjects required medication 
      for asthma, 11 had a FEV1 less than or equal to 85% predicted, and all subjects 
      had a PC20 less than or equal to 16 mg/ml. Twelve of 25 serum samples assessed 
      showed high levels of specific immunoglobulin E (IgE) antibodies to crab meat 
      and/or boiling water. At the time of the first follow-up, there was a reduction 
      in the number of subjects still requiring medication, with a significant 
      reduction in FEV1, and a PC20 less than or equal to 16 mg/ml. However, no further 
      change was observed afterwards. Similarly, the mean FEV1 and FEV1/FVC improved 
      significantly from the time of diagnosis to the first follow-up (p less than 
      0.01), with a plateau thereafter.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Malo, J L
AU  - Malo JL
AD  - Department of Chest Medicine, Hopital du Sacre-Coeur, Montreal, Canada.
FAU - Cartier, A
AU  - Cartier A
FAU - Ghezzo, H
AU  - Ghezzo H
FAU - Lafrance, M
AU  - Lafrance M
FAU - McCants, M
AU  - McCants M
FAU - Lehrer, S B
AU  - Lehrer SB
LA  - eng
GR  - AI-19266/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am Rev Respir Dis
JT  - The American review of respiratory disease
JID - 0370523
RN  - 0 (Antibodies)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Antibodies/*analysis
MH  - Asthma/*etiology/physiopathology
MH  - *Brachyura/immunology
MH  - Bronchi/*physiopathology
MH  - Environmental Exposure
MH  - Female
MH  - *Food-Processing Industry
MH  - Forced Expiratory Volume
MH  - Humans
MH  - Immunoglobulin E/*immunology
MH  - Male
MH  - Spirometry
MH  - Vital Capacity
EDAT- 1988/10/01 00:00
MHDA- 1988/10/01 00:01
CRDT- 1988/10/01 00:00
PHST- 1988/10/01 00:00 [pubmed]
PHST- 1988/10/01 00:01 [medline]
PHST- 1988/10/01 00:00 [entrez]
AID - 10.1164/ajrccm/138.4.807 [doi]
PST - ppublish
SO  - Am Rev Respir Dis. 1988 Oct;138(4):807-12. doi: 10.1164/ajrccm/138.4.807.