PMID- 32025447
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 12
IP  - 1
DP  - 2020 Jan 27
TI  - Intravenous Immunoglobulin in the Management of Lupus Erythematosus Panniculitis.
PG  - e6790
LID - 10.7759/cureus.6790 [doi]
LID - e6790
AB  - Lupus erythematosus panniculitis (LEP) is a rare variant of cutaneous lupus 
      erythematosus (CLE). It is characterized by the presence of a chronic 
      inflammatory process involving the deep dermis and subcutaneous tissues. It 
      commonly presents as deep indurated nodules or sharply demarcated plaques. 
      Antimalarial medications are considered first-line therapy for most cases of LEP 
      while systemic corticosteroids are saved for more resistant lesions. Intravenous 
      immunoglobulin (IVIG) is made up of concentrated polyclonal immunoglobulin G 
      (IgG) fractionated from the blood of healthy blood donors. Nowadays, it is used 
      for the treatment of numerous autoimmune and systemic inflammatory diseases. In 
      this case, we report the case of a female with multiple LEP and discoid lupus 
      erythematosus (DLE) lesions refractory to multiple standard therapy modalities 
      that responded dramatically to IVIG.
CI  - Copyright (c) 2020, AlQadri et al.
FAU - AlQadri, Nada G
AU  - AlQadri NG
AD  - Department of Dermatology, Alfaisal University College of Medicine, Riyadh, SAU.
FAU - AlNooh, Bayan
AU  - AlNooh B
AD  - Department of Dermatology, King Khalid University Hospital, Riyadh, SAU.
FAU - AlTewerki, Malak M
AU  - AlTewerki MM
AD  - Department of Neuroscience, King Faisal Specialist Hospital and Research Centre, 
      Riyadh, SAU.
FAU - Almotairi, Ahmad
AU  - Almotairi A
AD  - Department of Pathology, King Saud University Medical City, Riyadh, SAU.
FAU - Alajlan, Saad
AU  - Alajlan S
AD  - Department of Dermatology, King Faisal Specialist Hospital and Research Centre, 
      Riyadh, SAU.
LA  - eng
PT  - Case Reports
DEP - 20200127
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC6988482
OTO - NOTNLM
OT  - chronic cutaneous lupus
OT  - cutaneous lupus
OT  - intravenous immunoglobulin
OT  - ivig
OT  - lupus
OT  - lupus erythematosus panniculitis
OT  - lupus erythematosus profundus
OT  - sle
COIS- The authors have declared that no competing interests exist.
EDAT- 2020/02/07 06:00
MHDA- 2020/02/07 06:01
PMCR- 2020/01/27
CRDT- 2020/02/07 06:00
PHST- 2020/02/07 06:00 [entrez]
PHST- 2020/02/07 06:00 [pubmed]
PHST- 2020/02/07 06:01 [medline]
PHST- 2020/01/27 00:00 [pmc-release]
AID - 10.7759/cureus.6790 [doi]
PST - epublish
SO  - Cureus. 2020 Jan 27;12(1):e6790. doi: 10.7759/cureus.6790.