PMID- 32025751
OWN - NLM
STAT- MEDLINE
DCOM- 20210104
LR  - 20210104
IS  - 1432-1041 (Electronic)
IS  - 0031-6970 (Linking)
VI  - 76
IP  - 5
DP  - 2020 May
TI  - High-risk medication in community care: a scoping review.
PG  - 623-638
LID - 10.1007/s00228-020-02838-8 [doi]
AB  - PURPOSE: To review the international literature related to high-risk medication 
      (HRM) in community care, in order to (1) define a definition of HRM and (2) list 
      the medication that is considered HRM in community care. METHODS: Scoping review: 
      Five databases were systematically searched (MEDLINE, Scopus, CINAHL, Web Of 
      Science, and Cochrane) and extended with a hand search of cited references. Two 
      researchers reviewed the papers independently. All extracted definitions and 
      lists of HRM were subjected to a self-developed quality appraisal. Data were 
      extracted, analysed and summarised in tables. Critical attributes were extracted 
      in order to analyse the definitions. RESULTS: Of the 109 papers retrieved, 36 met 
      the inclusion criteria and were included in this review. Definitions for HRM in 
      community care were used inconsistently among the papers, and various recurrent 
      attributes of the concept HRM were used. Taking the recurrent attributes and the 
      quality score of the definitions into account, the following definition could be 
      derived: "High-risk medication are medications with an increased risk of 
      significant harm to the patient. The consequences of this harm can be more 
      serious than those with other medications". A total of 66 specific medications or 
      categories were extracted from the papers. Opioids, insulin, warfarin, heparin, 
      hypnotics and sedatives, chemotherapeutic agents (excluding hormonal agents), 
      methotrexate and hypoglycaemic agents were the most common reported HRM in 
      community care. CONCLUSION: The existing literature pertaining to HRM in 
      community care was examined. The definitions and medicines reported as HRM in the 
      literature are used inconsistently. We suggested a definition for more consistent 
      use in future research and policy. Future research is needed to determine more 
      precisely which definitions should be considered for HRM in community care.
FAU - Dumitrescu, Irina
AU  - Dumitrescu I
AUID- ORCID: 0000-0001-6001-8964
AD  - Department of Nursing Science and Midwifery, Centre For Research and Innovation 
      in Care (CRIC), Nurse and Pharmaceutical Care (NuPhaC), Faculty of Medicine and 
      Health Sciences, University of Antwerp, Antwerp, Belgium. 
      irina.dumitrescu@vlaanderen.wgk.be.
AD  - White-Yellow Cross of Flanders, Brussels, Belgium. 
      irina.dumitrescu@vlaanderen.wgk.be.
FAU - Casteels, Minne
AU  - Casteels M
AUID- ORCID: 0000-0001-9401-5489
AD  - White-Yellow Cross of Flanders, Brussels, Belgium.
AD  - Clinical Pharmacology and Pharmacotherapy, KU Leuven, Leuven, Belgium.
FAU - De Vliegher, Kristel
AU  - De Vliegher K
AD  - White-Yellow Cross of Flanders, Brussels, Belgium.
FAU - Dilles, Tinne
AU  - Dilles T
AUID- ORCID: 0000-0003-2817-0944
AD  - Department of Nursing Science and Midwifery, Centre For Research and Innovation 
      in Care (CRIC), Nurse and Pharmaceutical Care (NuPhaC), Faculty of Medicine and 
      Health Sciences, University of Antwerp, Antwerp, Belgium.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200205
PL  - Germany
TA  - Eur J Clin Pharmacol
JT  - European journal of clinical pharmacology
JID - 1256165
SB  - IM
MH  - Community Health Services/*standards
MH  - Humans
MH  - Qualitative Research
OTO - NOTNLM
OT  - Community care
OT  - Community health nurses
OT  - High-risk medication
OT  - Home care nurse
OT  - Medication care
EDAT- 2020/02/07 06:00
MHDA- 2021/01/05 06:00
CRDT- 2020/02/07 06:00
PHST- 2019/08/02 00:00 [received]
PHST- 2020/01/23 00:00 [accepted]
PHST- 2020/02/07 06:00 [pubmed]
PHST- 2021/01/05 06:00 [medline]
PHST- 2020/02/07 06:00 [entrez]
AID - 10.1007/s00228-020-02838-8 [pii]
AID - 10.1007/s00228-020-02838-8 [doi]
PST - ppublish
SO  - Eur J Clin Pharmacol. 2020 May;76(5):623-638. doi: 10.1007/s00228-020-02838-8. 
      Epub 2020 Feb 5.