PMID- 32026360
OWN - NLM
STAT- MEDLINE
DCOM- 20201221
LR  - 20201221
IS  - 1476-3524 (Electronic)
IS  - 1029-8428 (Linking)
VI  - 37
IP  - 4
DP  - 2020 Apr
TI  - Naturally Occurring Antibodies to Tau Exists in Human Blood and Are Not Changed 
      in Alzheimer's Disease.
PG  - 1029-1035
LID - 10.1007/s12640-020-00161-9 [doi]
AB  - Hyperphosphorylated tau is an important pathological agent in Alzheimer's disease 
      (AD). Tau effluxes from the brain to the blood could potentially stimulate the 
      production of naturally occurring antibodies (NAbs). We aimed to investigate 
      whether NAbs to tau (NAbs-tau) was generated in human blood and to figure out the 
      alteration of plasma NAbs-tau level in AD patients. About 192 AD patients and 192 
      age-matched and non-demented controls (NC) were enrolled in the present study. 
      Immunofluorescence staining and western blot assays were used to confirm the 
      existence of NAbs-tau in human blood. The plasma level of NAbs-tau in NC and AD 
      group was analyzed by ELISA. Immunofluorescence staining and western blot assays 
      confirmed the existence of NAbs-tau in human blood. However, no significant 
      difference in the plasma level of NAbs-tau was observed between NC and AD group. 
      Furthermore, the plasma level of NAbs-tau had no significant correlation with 
      MMSE scores. The present study confirmed that NAbs-tau exists in human blood but 
      does not differ in level between the NC and AD group. Plasma NAbs-tau is not a 
      reliable biomarker for AD.
FAU - Yu, Zhong-Yuan
AU  - Yu ZY
AD  - Department of Neurology and Clinical Center for Neuroscience, Daping Hospital, 
      Third Military Medical University (Army Medical University), Chongqing, China.
AD  - Basic Medical College, Third Military Medical University (Army Medical 
      University), Chongqing, China.
FAU - Li, Wei-Wei
AU  - Li WW
AD  - Department of Neurology and Clinical Center for Neuroscience, Daping Hospital, 
      Third Military Medical University (Army Medical University), Chongqing, China.
FAU - Yang, Hai-Mei
AU  - Yang HM
AD  - Department of Neurology and Clinical Center for Neuroscience, Daping Hospital, 
      Third Military Medical University (Army Medical University), Chongqing, China.
FAU - Manucat-Tan, Noralyn B
AU  - Manucat-Tan NB
AD  - School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, 
      Australia.
FAU - Wang, Jun
AU  - Wang J
AD  - Department of Neurology and Clinical Center for Neuroscience, Daping Hospital, 
      Third Military Medical University (Army Medical University), Chongqing, China.
FAU - Wang, Ye-Ran
AU  - Wang YR
AD  - Department of Neurology and Clinical Center for Neuroscience, Daping Hospital, 
      Third Military Medical University (Army Medical University), Chongqing, China.
FAU - Sun, Bin-Lu
AU  - Sun BL
AD  - Department of Neurology and Clinical Center for Neuroscience, Daping Hospital, 
      Third Military Medical University (Army Medical University), Chongqing, China.
FAU - Hu, Zi-Cheng
AU  - Hu ZC
AD  - Department of Neurology and Clinical Center for Neuroscience, Daping Hospital, 
      Third Military Medical University (Army Medical University), Chongqing, China.
FAU - Zhang, Li-Li
AU  - Zhang LL
AD  - Department of Neurology and Clinical Center for Neuroscience, Daping Hospital, 
      Third Military Medical University (Army Medical University), Chongqing, China.
FAU - Tan, Liang
AU  - Tan L
AD  - Southwest hospital, Third Military Medical University (Army Medical University), 
      Chongqing, China.
FAU - Deng, Juan
AU  - Deng J
AD  - Department of Healthy Management, Research Institute of Surgery, Daping Hospital, 
      Third Military Medical University (Army Medical University), Chongqing, 400042, 
      China. dj941@sina.com.
FAU - Liu, Yu-Hui
AU  - Liu YH
AD  - Department of Neurology and Clinical Center for Neuroscience, Daping Hospital, 
      Third Military Medical University (Army Medical University), Chongqing, China. 
      liuyuhui07-8909@163.com.
LA  - eng
GR  - 81600936/National Natural Science Foundation of China/
GR  - 81671277/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20200205
PL  - United States
TA  - Neurotox Res
JT  - Neurotoxicity research
JID - 100929017
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 0 (MAPT protein, human)
RN  - 0 (tau Proteins)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*blood/*diagnostic imaging/epidemiology
MH  - Animals
MH  - Autoantibodies/*blood
MH  - Biomarkers/blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Middle Aged
MH  - tau Proteins/*blood
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Biomarker
OT  - Naturally occurring antibodies to tau
OT  - Tau
EDAT- 2020/02/07 06:00
MHDA- 2020/12/22 06:00
CRDT- 2020/02/07 06:00
PHST- 2019/10/21 00:00 [received]
PHST- 2020/01/04 00:00 [accepted]
PHST- 2019/12/28 00:00 [revised]
PHST- 2020/02/07 06:00 [pubmed]
PHST- 2020/12/22 06:00 [medline]
PHST- 2020/02/07 06:00 [entrez]
AID - 10.1007/s12640-020-00161-9 [pii]
AID - 10.1007/s12640-020-00161-9 [doi]
PST - ppublish
SO  - Neurotox Res. 2020 Apr;37(4):1029-1035. doi: 10.1007/s12640-020-00161-9. Epub 
      2020 Feb 5.