PMID- 32026423
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210422
IS  - 2364-1746 (Electronic)
IS  - 2364-1754 (Print)
IS  - 2364-1754 (Linking)
VI  - 5
IP  - 1
DP  - 2019 Jun
TI  - In Vitro Study of the Effect of Breathing Pattern on Aerosol Delivery During 
      High-Flow Nasal Therapy.
PG  - 43-54
LID - 10.1007/s41030-019-0086-x [doi]
AB  - INTRODUCTION: The use of concurrent aerosol delivery during high-flow nasal 
      therapy (HFNT) may be exploited to facilitate delivery of a variety of prescribed 
      medications for inhalation. The study assessed the effect of tidal volume, breath 
      rate, and inspiratory:expiratory (I:E) ratio on the quantity of aerosol captured 
      at the level of the trachea during simulated HFNT. METHODS: Testing was completed 
      according to a factorial statistical design of experiments (DOE) approach. 
      Tracheal dose was characterized with a vibrating mesh nebulizer (Aerogen Solo, 
      Aerogen Ltd) using simulated adult, small child, and infant HFNT models. 
      Furthermore, aerosol delivery was evaluated across a range of adult patient 
      profiles with clinically representative test setups. RESULTS: Aerosol delivery 
      increased with a large tidal volume, a rapid breath rate, and a long inspiratory 
      time. Tidal volume, breath rate, and I:E ratio each had a significant effect on 
      tracheal dose across simulated adult, small child, and infant breathing. 
      CONCLUSION: The main trends that were identified in the statistical DOE predicted 
      aerosol delivery across adult patient breathing profiles, in terms of tidal 
      volume, breath rate, and I:E ratio. Therefore, patients with distressed breathing 
      profiles may be expected to receive a larger aerosol dose than those with normal 
      breathing rates. FUNDING: Aerogen Limited.
FAU - Bennett, Gavin
AU  - Bennett G
AD  - Aerogen Limited, IDA Business Park, Dangan, Galway, Ireland. 
      gbennett@aerogen.com.
FAU - Joyce, Mary
AU  - Joyce M
AD  - Aerogen Limited, IDA Business Park, Dangan, Galway, Ireland.
FAU - Sweeney, Louise
AU  - Sweeney L
AD  - Aerogen Limited, IDA Business Park, Dangan, Galway, Ireland.
FAU - MacLoughlin, Ronan
AU  - MacLoughlin R
AD  - Aerogen Limited, IDA Business Park, Dangan, Galway, Ireland.
LA  - eng
PT  - Journal Article
DEP - 20190206
PL  - United States
TA  - Pulm Ther
JT  - Pulmonary therapy
JID - 101687144
PMC - PMC6967176
OTO - NOTNLM
OT  - Aerosol
OT  - Breathing profile
OT  - High-flow nasal therapy
OT  - Tracheal dose
OT  - Vibrating mesh nebulizer
EDAT- 2020/02/07 06:00
MHDA- 2020/02/07 06:01
PMCR- 2019/02/06
CRDT- 2020/02/07 06:00
PHST- 2018/12/12 00:00 [received]
PHST- 2020/02/07 06:00 [entrez]
PHST- 2020/02/07 06:00 [pubmed]
PHST- 2020/02/07 06:01 [medline]
PHST- 2019/02/06 00:00 [pmc-release]
AID - 10.1007/s41030-019-0086-x [pii]
AID - 86 [pii]
AID - 10.1007/s41030-019-0086-x [doi]
PST - ppublish
SO  - Pulm Ther. 2019 Jun;5(1):43-54. doi: 10.1007/s41030-019-0086-x. Epub 2019 Feb 6.