PMID- 32027296
OWN - NLM
STAT- MEDLINE
DCOM- 20200220
LR  - 20200310
IS  - 1009-2137 (Print)
IS  - 1009-2137 (Linking)
VI  - 28
IP  - 1
DP  - 2020 Feb
TI  - [Research Advance on In Vitro Generation of Human Hematopoietic Stem Cells for 
      Transplantation--Review].
PG  - 320-324
LID - 10.19746/j.cnki.issn.1009-2137.2020.01.053 [doi]
AB  - Abstract　　Currently, hematopoietic stem cell (HSC) transplantation is widely used 
      in the therapy of hematological malignancies, non-malignant refractory anemia, 
      genetic diseases and certain tumors with satisfactory therapeutic efficacy. HSC 
      sources used for transplantation include bone marrow, mobilized peripheral blood 
      and neonate umbilical cord blood. However, for many patients, sufficient number 
      of human leukocyte antigen (HLA) -matched HSC cannot be found for 
      transplantation, because the number of HSC in these tissues is small and 
      HLA-identical donors are rare. Thus, in vitro generation of HSC has recently been 
      focused. At present, the origin of HSC is hPSC, including hESC and hiPSC, which 
      is worth to be the new origin of HSC transplantation. However, to generate 
      functional hematopoietic stem cells which have efficient multi-lineage 
      differentiation and in vivo engraftment potentials still is a big challenge to be 
      confronted. In this review, the recent technical progress in HSC generation is 
      summarizd, and the problems to be solved and new challenges to be confronted were 
      discussed.
FAU - Zhang, Qing-Yun
AU  - Zhang QY
AD  - State Key Laboratory of Experimental Hematology, National Clinical Research 
      Center for Blood Disease, Institute of Hematology & Blood Disease Hospital, 
      Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 
      300020, China,Department of Stem Cell & Regenerative Medicine, Peking Union 
      Medical College, Tianjin 300020, China.
FAU - Dong, Fang
AU  - Dong F
AD  - State Key Laboratory of Experimental Hematology, National Clinical Research 
      Center for Blood Disease, Institute of Hematology & Blood Disease Hospital, 
      Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 
      300020, China,Department of Stem Cell & Regenerative Medicine, Peking Union 
      Medical College, Tianjin 300020, China.
FAU - Ema, Hideo
AU  - Ema H
AD  - State Key Laboratory of Experimental Hematology, National Clinical Research 
      Center for Blood Disease, Institute of Hematology & Blood Disease Hospital, 
      Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 
      300020, China,Department of Stem Cell & Regenerative Medicine, Peking Union 
      Medical College, Tianjin 300020, China,E-mail: hema@ihcams.ac.cn.
LA  - chi
PT  - Journal Article
PT  - Review
PL  - China
TA  - Zhongguo Shi Yan Xue Ye Xue Za Zhi
JT  - Zhongguo shi yan xue ye xue za zhi
JID - 101084424
SB  - IM
MH  - Bone Marrow
MH  - Fetal Blood
MH  - *Hematologic Neoplasms
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Hematopoietic Stem Cells
MH  - Humans
EDAT- 2020/02/07 06:00
MHDA- 2020/02/23 06:00
CRDT- 2020/02/07 06:00
PHST- 2020/02/07 06:00 [entrez]
PHST- 2020/02/07 06:00 [pubmed]
PHST- 2020/02/23 06:00 [medline]
AID - 1009-2137(2020)01-0320-05 [pii]
AID - 10.19746/j.cnki.issn.1009-2137.2020.01.053 [doi]
PST - ppublish
SO  - Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2020 Feb;28(1):320-324. doi: 
      10.19746/j.cnki.issn.1009-2137.2020.01.053.