PMID- 32027402
OWN - NLM
STAT- MEDLINE
DCOM- 20210507
LR  - 20210517
IS  - 1651-2227 (Electronic)
IS  - 0803-5253 (Linking)
VI  - 109
IP  - 8
DP  - 2020 Aug
TI  - The effects of proton pump inhibitors on the microbiome in young children.
PG  - 1531-1538
LID - 10.1111/apa.15213 [doi]
AB  - AIM: The use of proton pump inhibitor (PPI) treatments are increasing among 
      paediatric patients worldwide. We aimed to review the effects of PPIs on the 
      microbiome and its associated effect on the gastrointestinal, respiratory and 
      metabolic systems. The role of probiotics is discussed. METHODS: We searched for 
      relevant articles published in English language in PubMed and Google Scholar. 
      Articles were extracted using subject heading and key words of interest to the 
      topic. RESULTS: There is evidence that PPIs modify the microbiome of the mouth, 
      gut and lungs. The specific adverse effects associated with PPIs were necrotising 
      enterocolitis, late onset sepsis in premature infants, Clostridium difficile 
      infection, asthma, obesity and small intestine bacterial overgrowth in young 
      children. Studies on the use of probiotics to counteract adverse effects of PPIs 
      were limited. CONCLUSION: PPIs create dysbiosis of the microbiome in the mouth, 
      gut and lungs in the paediatric population. Probiotics could restore dysbiosis 
      but it has very poorly been studied if probiotics can counteract or prevent PPI 
      induced adverse effects.
CI  - (c) 2020 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.
FAU - Levy, Elvira I
AU  - Levy EI
AD  - KidZ Health Castle, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, 
      Brussels, Belgium.
FAU - Hoang, Delphine M
AU  - Hoang DM
AD  - KidZ Health Castle, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, 
      Brussels, Belgium.
FAU - Vandenplas, Yvan
AU  - Vandenplas Y
AUID- ORCID: 0000-0002-1862-8651
AD  - KidZ Health Castle, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, 
      Brussels, Belgium.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200318
PL  - Norway
TA  - Acta Paediatr
JT  - Acta paediatrica (Oslo, Norway : 1992)
JID - 9205968
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
CIN - Acta Paediatr. 2021 May;110(5):1690. PMID: 32965745
MH  - Child
MH  - Child, Preschool
MH  - *Clostridium Infections
MH  - Dysbiosis
MH  - Humans
MH  - Infant
MH  - *Microbiota
MH  - *Probiotics
MH  - Proton Pump Inhibitors/adverse effects
OTO - NOTNLM
OT  - H2 receptor antagonist
OT  - Lactobacillus
OT  - microbiome
OT  - probiotic
OT  - proton pump inhibitor
OT  - small intestinal bacterial overgrowth
EDAT- 2020/02/07 06:00
MHDA- 2021/05/08 06:00
CRDT- 2020/02/07 06:00
PHST- 2019/10/28 00:00 [received]
PHST- 2020/01/22 00:00 [revised]
PHST- 2020/02/04 00:00 [accepted]
PHST- 2020/02/07 06:00 [pubmed]
PHST- 2021/05/08 06:00 [medline]
PHST- 2020/02/07 06:00 [entrez]
AID - 10.1111/apa.15213 [doi]
PST - ppublish
SO  - Acta Paediatr. 2020 Aug;109(8):1531-1538. doi: 10.1111/apa.15213. Epub 2020 Mar 
      18.