PMID- 32027443
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20210621
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Linking)
VI  - 52
IP  - 4
DP  - 2020 Aug
TI  - Retinal ON and OFF pathways contribute to initial optokinetic responses with 
      different temporal characteristics.
PG  - 3160-3165
LID - 10.1111/ejn.14697 [doi]
AB  - Visual information in the retina is processed via two pathways: ON and OFF 
      pathways that originate from ON and OFF bipolar cells. The differences in the 
      receptors that mediate signal transmission from photoreceptors imply that the 
      response speed to light signals differs between ON and OFF pathways. We studied 
      the initial optokinetic responses (OKRs) of mice using two-frame motion stimuli 
      presented with interstimulus intervals (ISIs) to understand functional difference 
      of these pathways. When two successive image frames were presented with an ISI, 
      observers often perceived motion in the opposite direction of the actual shift. 
      This directional reversal results from the biphasic nature of the temporal 
      filters in visual systems whose characteristics can be estimated from the 
      dependence on ISIs. We examined the dependence on ISIs in the OKRs of TRPM1(-/-) 
      mice, whose ON bipolar cells are dysfunctional, as well as in those of wild-type 
      control mice. Wild type and TRPM1(-/-) mice showed comparable OKRs in the 
      veridical direction when no ISI was present. Both types of mice showed OKRs that 
      decreased and eventually reversed as the ISI increased, but with a directional 
      reversal at a shorter ISI in TRPM1(-/-) than wild-type mice. In addition, the 
      temporal filters of TRPM1(-/-) mice estimated from dependence on ISIs were tuned 
      for higher frequencies, suggesting that compared with wild-type mice, the visual 
      system of TRPM1(-/-) mice responds to light signals with faster dynamics. We 
      conclude that the ON and OFF pathways contribute to initial OKRs by providing 
      visual signals processed with different temporal resolutions.
CI  - (c) 2020 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
FAU - Sugita, Yuko
AU  - Sugita Y
AD  - Laboratory for Molecular and Developmental Biology, Institute for Protein 
      Research, Osaka University, Osaka, Japan.
FAU - Miura, Kenichiro
AU  - Miura K
AUID- ORCID: 0000-0002-3722-7837
AD  - Department of Integrative Brain Science, Graduate School of Medicine, Kyoto 
      University, Kyoto, Japan.
AD  - Department of Pathology of Mental Diseases, National Center of Neurology and 
      Psychiatry, National Institute of Mental Health, Tokyo, Japan.
FAU - Furukawa, Takahisa
AU  - Furukawa T
AD  - Laboratory for Molecular and Developmental Biology, Institute for Protein 
      Research, Osaka University, Osaka, Japan.
LA  - eng
GR  - JP19dm0207069/Japan Agency for Medical Research and Development/
GR  - Takeda Science Foundation/
GR  - Uehara Memorial Foundation/
GR  - #18K14850, #18H02593/Japan Society for the Promotion of Science/
GR  - Grant-in-Aid for Challenging Research (Exploratory/Japan Society for the 
      Promotion of Science/
GR  - Grant-in-Aid for Scientific Research (15K06709)/Japan Society for the Promotion 
      of Science/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200225
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
SB  - IM
MH  - Animals
MH  - Mice
MH  - *Nystagmus, Optokinetic
MH  - Photic Stimulation
MH  - Reaction Time
MH  - *Retina
MH  - Retinal Bipolar Cells
OTO - NOTNLM
OT  - ISI
OT  - TRPM1
OT  - bipolar cells
OT  - eye movement
OT  - optokinetic responses
EDAT- 2020/02/07 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/02/07 06:00
PHST- 2019/09/17 00:00 [received]
PHST- 2020/01/05 00:00 [revised]
PHST- 2020/01/29 00:00 [accepted]
PHST- 2020/02/07 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/02/07 06:00 [entrez]
AID - 10.1111/ejn.14697 [doi]
PST - ppublish
SO  - Eur J Neurosci. 2020 Aug;52(4):3160-3165. doi: 10.1111/ejn.14697. Epub 2020 Feb 
      25.