PMID- 32029045
OWN - NLM
STAT- MEDLINE
DCOM- 20200217
LR  - 20200217
IS  - 2095-4352 (Print)
VI  - 31
IP  - 12
DP  - 2019 Dec
TI  - [Late gadolinium enhancement and T1 mapping for the diagnosis of cardiac 
      amyloidosis].
PG  - 1538-1541
LID - 10.3760/cma.j.issn.2095-4352.2019.12.021 [doi]
AB  - OBJECTIVE: To explore the role of late gadolinium enhancement (LGE) and T1 
      mapping for detection of cardiac amyloidosis. METHODS: Nine cases of cardiac 
      amyloidosis who had diagnosed by renal biopsy diagnosed type light-chain (AL) 
      amyloidosis and acute heart failure suspected involvement of the heart in Tianjin 
      First Central Hospital from May 2018 to March 2019 were enrolled, and at the same 
      time 14 cases of non-obstructive hypertrophic cardiomyopathy patients, 12 cases 
      of healthy physical examination at the same period were enrolled as the control. 
      All patients underwent Philips 3.0-T including plain scan as cine, T2WI, native 
      T1 mapping and enhanced scan as perfusion, LGE imaging, post T1 mapping. For LGE 
      cardiac magnetic resonance imaging (CMRI), a bolus of 0.1 mL/kg of 
      gadolinium-based contrast followed by a 20 mL saline flush was administered. 
      After a 7-minutes delay, ECG-gated images were acquired in 3 long-axis and a 
      stack of short-axis slices identical to those of cine images using a breath-hold 
      gradient recalled echo phase-sensitive or magnitude only inversion recovery 
      sequence. LGE and T1 mapping CMRI observation, including cardiac function index 
      [left ventricle end-diastolic volume (LVEDV), left ventricle end-systolic volume 
      (LVESV), left ventricular ejection fraction (LVEF), valvular regurgitation], 
      cardiac morphological index [including left ventricular wall thickness, left 
      ventricular weight (LVM)], myocardial histological characteristics and markers 
      N-terminal pro-brain natriuretic peptide (NT-proBNP) and accompanying signs 
      (including pericardial effusion, pleural effusion) were performed. RESULTS: The 
      predominant LGE pattern in amyloidosis was diffuse left ventricular sub 
      endocardial enhancement (3/9), diffuse in left ventricular wall enhancement 
      (3/9), and transmural delayed enhancement in left ventricular (2/9) and 
      non-typical delayed enhancement (1/9). Myocardial T1 was significantly elevated 
      in cardiac AL amyloidosis patients compared to normal subjects and hypertrophic 
      cardiomyopathy (ms: 1 497.3+/-22.0 vs. 1 273.3+/-30.1, 1 329.3+/-42.6, both P < 0.05). 
      Myocardial T1 was increased in AL amyloid before LGE. A post-contrast myocardial 
      T1 was significantly elevated in cardiac AL amyloidosis patients compared to 
      normal subjects and hypertrophic cardiomyopathy (ms: 476.7+/-44.2 vs. 516.1+/-41.5, 
      569.9+/-12.3, both P > 0.05). Three of 9 amyloidosis patients with review images 
      showing T1 value and cardiac function was no significantly different with the 
      first check (ms: 1 484.8+/-6.5 vs. 1 497.3+/-22.0, P = 0.11). CONCLUSIONS: One-stop 
      CMRI can improve the diagnosis of cardiac amyloidosis, LGE can display the 
      myocardial scarring and fibrosis, and T1 mapping is sensitive to myocardial edema 
      and diffuse fibrosis. LGE and T1 mapping can improve the diagnostic accuracy, 
      which is very meaningful for diagnosis and follow-up of patients.
FAU - Cui, Qian
AU  - Cui Q
AD  - Department of Radiology, Tianjin First Center Hospital, Tianjin 300192, China. 
      Corresponding author: Shen Wen, Email: shenwen66happy@163.com.
FAU - Yu, Jing
AU  - Yu J
FAU - Shen, Wen
AU  - Shen W
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
JT  - Zhonghua wei zhong bing ji jiu yi xue
JID - 101604552
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Amyloidosis/*diagnosis
MH  - Contrast Media
MH  - *Gadolinium
MH  - Heart
MH  - Humans
MH  - Myocardium
MH  - Predictive Value of Tests
EDAT- 2020/02/08 06:00
MHDA- 2020/02/18 06:00
CRDT- 2020/02/08 06:00
PHST- 2020/02/08 06:00 [entrez]
PHST- 2020/02/08 06:00 [pubmed]
PHST- 2020/02/18 06:00 [medline]
AID - 10.3760/cma.j.issn.2095-4352.2019.12.021 [doi]
PST - ppublish
SO  - Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2019 Dec;31(12):1538-1541. doi: 
      10.3760/cma.j.issn.2095-4352.2019.12.021.