PMID- 32031301
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20210621
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Linking)
VI  - 42
IP  - 8
DP  - 2020 Aug
TI  - Efficacy and safety of accelerated fractionated radiotherapy without elective 
      nodal irradiation for T3N0 glottic cancer without vocal cord fixation.
PG  - 1775-1782
LID - 10.1002/hed.26092 [doi]
AB  - BACKGROUND: The purpose of this study was to evaluate accelerated fractionated 
      radiotherapy (AFRT) without elective nodal irradiation (ENI) for T3N0 glottic 
      cancer (GC) without vocal cord fixation, especially in comparison with 
      chemoradiotherapy (CRT) and hyperfractionated radiotherapy (HFRT) both of which 
      included ENI. METHODS: The medical charts of patients with T3N0GC without cord 
      fixation received definitive radiotherapy between June 2005 and March 2018 were 
      reviewed. RESULTS: A total of 74 patients were analyzed. After a median follow-up 
      time of 46 months (range, 12-141), 3-year local failure in AFRT/CRT/HFRT (n = 
      41/10/23) was 10%/20%/26%, 3-year regional failure 6%/0%/9%, 3-year 
      progression-free survival 71%/69%/74%, and 3-year overall survival 77%/100%/87%. 
      There were no significant differences among three groups in recurrence or 
      survival. Grade 3 adverse events (AEs) were noted in 5/2/8 patients (12%/20%/35%) 
      in AFRT/CRT/HFRT, respectively. There were no Grade 4/5 AEs. CONCLUSIONS: AFRT 
      without ENI is an effective and feasible treatment for T3N0GC without cord 
      fixation.
CI  - (c) 2020 Wiley Periodicals, Inc.
FAU - Okumura, Masayuki
AU  - Okumura M
AUID- ORCID: 0000-0002-9842-165X
AD  - Department of Radiation Oncology, National Cancer Center Hospital East, Chiba, 
      Japan.
AD  - Department of Radiology, Nagoya University Graduate School of Medicine, Aichi, 
      Japan.
FAU - Motegi, Atsushi
AU  - Motegi A
AUID- ORCID: 0000-0001-5231-6443
AD  - Department of Radiation Oncology, National Cancer Center Hospital East, Chiba, 
      Japan.
FAU - Zenda, Sadamoto
AU  - Zenda S
AD  - Department of Radiation Oncology, National Cancer Center Hospital East, Chiba, 
      Japan.
FAU - Nakamura, Naoki
AU  - Nakamura N
AD  - Department of Radiation Oncology, National Cancer Center Hospital East, Chiba, 
      Japan.
FAU - Hojo, Hidehiro
AU  - Hojo H
AD  - Department of Radiation Oncology, National Cancer Center Hospital East, Chiba, 
      Japan.
FAU - Nakamura, Masaki
AU  - Nakamura M
AD  - Department of Radiation Oncology, National Cancer Center Hospital East, Chiba, 
      Japan.
FAU - Hirano, Yasuhiro
AU  - Hirano Y
AD  - Department of Radiation Oncology, National Cancer Center Hospital East, Chiba, 
      Japan.
FAU - Kageyama, Shun-Ichiro
AU  - Kageyama SI
AD  - Department of Radiation Oncology, National Cancer Center Hospital East, Chiba, 
      Japan.
FAU - Arahira, Satoko
AU  - Arahira S
AD  - Department of Radiation Oncology, National Cancer Center Hospital East, Chiba, 
      Japan.
FAU - Parshuram, Raturi Vijay
AU  - Parshuram RV
AUID- ORCID: 0000-0002-1687-1957
AD  - Department of Radiation Oncology, National Cancer Center Hospital East, Chiba, 
      Japan.
FAU - Kuno, Hirofumi
AU  - Kuno H
AD  - Department of Diagnostic Radiology, National Cancer Center Hospital East, Chiba, 
      Japan.
FAU - Hayashi, Ryuichi
AU  - Hayashi R
AD  - Department of Head and Neck Surgery, National Cancer Center Hospital East, Chiba, 
      Japan.
FAU - Tahara, Makoto
AU  - Tahara M
AD  - Department of Head and Neck Medical Oncology, National Cancer Center Hospital 
      East, Chiba, Japan.
FAU - Itoh, Yoshiyuki
AU  - Itoh Y
AD  - Department of Radiology, Nagoya University Graduate School of Medicine, Aichi, 
      Japan.
FAU - Naganawa, Shinji
AU  - Naganawa S
AD  - Department of Radiology, Nagoya University Graduate School of Medicine, Aichi, 
      Japan.
FAU - Akimoto, Tetsuo
AU  - Akimoto T
AD  - Department of Radiation Oncology, National Cancer Center Hospital East, Chiba, 
      Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200207
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
SB  - IM
MH  - Chemoradiotherapy
MH  - Dose Fractionation, Radiation
MH  - Humans
MH  - *Laryngeal Neoplasms/radiotherapy
MH  - Neoplasm Recurrence, Local
MH  - *Vocal Cords
OTO - NOTNLM
OT  - T3 N0 category
OT  - accelerated fractionated radiotherapy
OT  - chemoradiotherapy
OT  - glottic cancer
OT  - hyperfractionated radiotherapy
EDAT- 2020/02/08 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/02/08 06:00
PHST- 2019/09/16 00:00 [received]
PHST- 2019/12/18 00:00 [revised]
PHST- 2020/01/15 00:00 [accepted]
PHST- 2020/02/08 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/02/08 06:00 [entrez]
AID - 10.1002/hed.26092 [doi]
PST - ppublish
SO  - Head Neck. 2020 Aug;42(8):1775-1782. doi: 10.1002/hed.26092. Epub 2020 Feb 7.