PMID- 3203134
OWN - NLM
STAT- MEDLINE
DCOM- 19890203
LR  - 20061115
IS  - 0006-341X (Print)
IS  - 0006-341X (Linking)
VI  - 44
IP  - 3
DP  - 1988 Sep
TI  - The equivalence of two tests and models for HLA data with no observed double 
      blanks.
PG  - 869-73
AB  - Gart and Nam (1984, Biometrics 40, 887-894) consider the analysis of an ABO-like 
      model based on the Hardy-Weinberg law in the commonly occurring case of human 
      leukocyte antigen (HLA) data where there are no double blanks, that is, no 
      recessive homozygotes. They derive a score test, based on the truncated 
      likelihood, of the hypothesis that the true recessive gene (or allele) frequency 
      is zero. Yasuda (1968, Biometrics 24, 915-935) considers a similar codominant 
      system wherein the true recessive gene frequency is assumed zero, but the 
      Hardy-Weinberg law does not hold. In particular, he considers the possibility of 
      a nonzero inbreeding coefficient. We show that the two models are equivalent; 
      each likelihood can be shown to be a reparameterization of the other. 
      Furthermore, the score test of the zero gene frequency in Gart and Nam is 
      identical to the score test for a zero inbreeding coefficient given by Yasuda. 
      The results are applied to an example wherein it appears that the Hardy-Weinberg 
      model is appropriate. Thus, it is not possible in this population to identify 
      homozygous individuals without error from phenotypic data alone.
FAU - Gart, J J
AU  - Gart JJ
AD  - Biostatistics Branch, National Cancer Institute, Bethesda, Maryland 20892.
FAU - Nam, J M
AU  - Nam JM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Biometrics
JT  - Biometrics
JID - 0370625
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Consanguinity
MH  - *Gene Frequency
MH  - Genes, Dominant
MH  - HLA Antigens/*genetics
MH  - Heterozygote
MH  - Homozygote
MH  - Humans
MH  - *Models, Genetic
EDAT- 1988/09/01 00:00
MHDA- 1988/09/01 00:01
CRDT- 1988/09/01 00:00
PHST- 1988/09/01 00:00 [pubmed]
PHST- 1988/09/01 00:01 [medline]
PHST- 1988/09/01 00:00 [entrez]
PST - ppublish
SO  - Biometrics. 1988 Sep;44(3):869-73.