PMID- 32033037
OWN - NLM
STAT- MEDLINE
DCOM- 20201117
LR  - 20201117
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 21
IP  - 3
DP  - 2020 Feb 4
TI  - Calmodulin-Binding Proteins in Muscle: A Minireview on Nuclear Receptor 
      Interacting Protein, Neurogranin, and Growth-Associated Protein 43.
LID - 10.3390/ijms21031016 [doi]
LID - 1016
AB  - Calmodulin (CaM) is an important Ca(2+)-sensing protein with numerous downstream 
      targets that are either CaM-dependant or CaM-regulated. In muscle, CaM-dependent 
      proteins, which are critical regulators of dynamic Ca(2+) handling and 
      contractility, include calcineurin (CaN), CaM-dependant kinase II (CaMKII), 
      ryanodine receptor (RyR), and dihydropyridine receptor (DHPR). CaM-regulated 
      targets include genes associated with oxidative metabolism, muscle plasticity, 
      and repair. Despite its importance in muscle, the regulation of CaM-particularly 
      its availability to bind to and activate downstream targets-is an emerging area 
      of research. In this minireview, we discuss recent studies revealing the 
      importance of small IQ motif proteins that bind to CaM to either facilitate 
      (nuclear receptor interacting protein; NRIP) its activation of downstream 
      targets, or sequester (neurogranin, Ng; and growth-associated protein 43, GAP43) 
      CaM away from their downstream targets. Specifically, we discuss recent studies 
      that have begun uncovering the physiological roles of NRIP, Ng, and GAP43 in 
      skeletal and cardiac muscle, thereby highlighting the importance of endogenously 
      expressed CaM-binding proteins and their regulation of CaM in muscle.
FAU - Moradi, Fereshteh
AU  - Moradi F
AD  - Department of Biological Sciences, Brock University, St. Catharines, ON L2S 3A1, 
      Canada.
FAU - Copeland, Emily N
AU  - Copeland EN
AD  - Centre for Neuroscience, Brock University, St. Catharines, ON L2S 3A1, Canada.
AD  - Centre for Bone and Muscle Health, Brock University, St. Catharines, ON L2S 3A1, 
      Canada.
FAU - Baranowski, Ryan W
AU  - Baranowski RW
AD  - Centre for Bone and Muscle Health, Brock University, St. Catharines, ON L2S 3A1, 
      Canada.
AD  - Department of Kinesiology, Brock University, St. Catharines, ON L2S 3A1, Canada.
FAU - Scholey, Aiden E
AU  - Scholey AE
AD  - Department of Kinesiology, Brock University, St. Catharines, ON L2S 3A1, Canada.
FAU - Stuart, Jeffrey A
AU  - Stuart JA
AUID- ORCID: 0000-0001-5894-0300
AD  - Department of Biological Sciences, Brock University, St. Catharines, ON L2S 3A1, 
      Canada.
FAU - Fajardo, Val A
AU  - Fajardo VA
AUID- ORCID: 0000-0003-4500-3347
AD  - Centre for Neuroscience, Brock University, St. Catharines, ON L2S 3A1, Canada.
AD  - Centre for Bone and Muscle Health, Brock University, St. Catharines, ON L2S 3A1, 
      Canada.
AD  - Department of Kinesiology, Brock University, St. Catharines, ON L2S 3A1, Canada.
LA  - eng
GR  - RGPIN 2019-05833/Natural Sciences and Engineering Research Council of Canada/
PT  - Journal Article
PT  - Review
DEP - 20200204
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Calmodulin)
RN  - 0 (GAP-43 Protein)
RN  - 0 (Nuclear Receptor Interacting Protein 1)
RN  - 132654-77-4 (Neurogranin)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Calcium/metabolism
MH  - Calcium Signaling/*physiology
MH  - Calmodulin/*metabolism
MH  - GAP-43 Protein/*metabolism
MH  - Humans
MH  - Muscle, Skeletal/metabolism
MH  - Myocardium/metabolism
MH  - Neurogranin/*metabolism
MH  - Nuclear Receptor Interacting Protein 1/*metabolism
PMC - PMC7038096
OTO - NOTNLM
OT  - CaMKII
OT  - GAP43
OT  - IQ-motif
OT  - NRIP
OT  - calcineurin
OT  - neurogranin
OT  - neuromodulin
COIS- The authors declare no conflict of interest.
EDAT- 2020/02/09 06:00
MHDA- 2020/11/18 06:00
PMCR- 2020/02/01
CRDT- 2020/02/09 06:00
PHST- 2019/12/16 00:00 [received]
PHST- 2020/01/27 00:00 [revised]
PHST- 2020/01/31 00:00 [accepted]
PHST- 2020/02/09 06:00 [entrez]
PHST- 2020/02/09 06:00 [pubmed]
PHST- 2020/11/18 06:00 [medline]
PHST- 2020/02/01 00:00 [pmc-release]
AID - ijms21031016 [pii]
AID - ijms-21-01016 [pii]
AID - 10.3390/ijms21031016 [doi]
PST - epublish
SO  - Int J Mol Sci. 2020 Feb 4;21(3):1016. doi: 10.3390/ijms21031016.