PMID- 32034842
OWN - NLM
STAT- MEDLINE
DCOM- 20210708
LR  - 20210708
IS  - 1521-2254 (Electronic)
IS  - 1099-498X (Linking)
VI  - 22
IP  - 5
DP  - 2020 May
TI  - Associations of MTRR A66G polymorphism and promoter methylation with ischemic 
      stroke in patients with hyperhomocysteinemia.
PG  - e3170
LID - 10.1002/jgm.3170 [doi]
AB  - BACKGROUND: Patients with hyperhomocysteinemia (HHcy) have a higher risk of 
      developing ischemic stroke (IS). The association between MTRR A66G polymorphism 
      and promoter methylation with IS in patients with HHcy is also uncertain. The 
      present study aimed to investigate the association between the MTRR polymorphism 
      and methylation with IS in HHcy patients. METHODS: This case-control study 
      included a total of 304 HHcy patients (95 with IS and 209 without IS). 
      Multivariate logistic regression analyses were applied to explore the association 
      between MTRR polymorphism and classical atherothrombotic risk factors with the 
      risk of IS. RESULTS: The log-additive and dominant models were markedly different 
      in participants with IS compared to the control group (p = 0.031 and 0.016, 
      respectively). The log-additive and dominant showed a significant association 
      with IS in the low level plasma homocysteine groups (p = 0.024 and 0.014, 
      respectively). No significant difference of methylation between IS and without IS 
      group (p > 0.05). Patients with high plasma homocysteine had a 4.041-4.941 fold 
      higher risk of IS (p = 0.01, 0.016 and 0.041, respectively) compared to the low 
      plasma homocysteine group. Age, diabetes, hypertension and plasma homocysteine 
      were the risk factors for IS in patients with HHcy (p = 0.033, 0.000, 0.001 and 
      0.038, respectively). CONCLUSIONS: MTRR A66G polymorphism and an elevated plasma 
      plasma homocysteine level were significantly associated with an increased risk of 
      IS in patients with HHcy. Age, diabetes, hypertension and Hcy were all found to 
      be associated with IS.
CI  - (c) 2020 John Wiley & Sons, Ltd.
FAU - Li, Dankang
AU  - Li D
AD  - Department of Epidemiology, School of Public Health, Zhengzhou University, 
      Zhengzhou, Henan, China.
FAU - Zhao, Qinglin
AU  - Zhao Q
AUID- ORCID: 0000-0001-7092-2148
AD  - Department of Epidemiology, School of Public Health, Zhengzhou University, 
      Zhengzhou, Henan, China.
FAU - Zhang, Chengda
AU  - Zhang C
AD  - Department of International Medicine, Beaumont Health System, Royal Oak, MI, USA.
FAU - Huang, Xiaowen
AU  - Huang X
AD  - Department of Epidemiology, School of Public Health, Zhengzhou University, 
      Zhengzhou, Henan, China.
FAU - Godfrey, Opolot
AU  - Godfrey O
AD  - Department of Epidemiology, School of Public Health, Zhengzhou University, 
      Zhengzhou, Henan, China.
FAU - Zhang, Weidong
AU  - Zhang W
AD  - Department of Epidemiology, School of Public Health, Zhengzhou University, 
      Zhengzhou, Henan, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200217
PL  - England
TA  - J Gene Med
JT  - The journal of gene medicine
JID - 9815764
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - EC 1.18.1.- (methionine synthase reductase)
RN  - EC 1.18.1.2 (Ferredoxin-NADP Reductase)
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - DNA Methylation
MH  - Female
MH  - Ferredoxin-NADP Reductase/*genetics
MH  - *Genetic Predisposition to Disease
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hyperhomocysteinemia/*blood/complications/*genetics/physiopathology
MH  - Ischemic Stroke/*blood/complications/*genetics/metabolism
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Promoter Regions, Genetic
MH  - Risk Factors
OTO - NOTNLM
OT  - MTRR
OT  - hyperhomocysteinemia
OT  - ischemic stroke
OT  - methylation
OT  - polymorphism
EDAT- 2020/02/09 06:00
MHDA- 2021/07/09 06:00
CRDT- 2020/02/09 06:00
PHST- 2019/08/31 00:00 [received]
PHST- 2020/01/12 00:00 [revised]
PHST- 2020/02/04 00:00 [accepted]
PHST- 2020/02/09 06:00 [pubmed]
PHST- 2021/07/09 06:00 [medline]
PHST- 2020/02/09 06:00 [entrez]
AID - 10.1002/jgm.3170 [doi]
PST - ppublish
SO  - J Gene Med. 2020 May;22(5):e3170. doi: 10.1002/jgm.3170. Epub 2020 Feb 17.