PMID- 32035254
OWN - NLM
STAT- MEDLINE
DCOM- 20201225
LR  - 20201225
IS  - 1873-3476 (Electronic)
IS  - 0378-5173 (Linking)
VI  - 579
DP  - 2020 Apr 15
TI  - Bile acid transporter mediated STC/Soluplus self-assembled hybrid nanoparticles 
      for enhancing the oral drug bioavailability.
PG  - 119120
LID - S0378-5173(20)30104-6 [pii]
LID - 10.1016/j.ijpharm.2020.119120 [doi]
AB  - The nano-particulate system for oral delivery faces a big challenge across the 
      gastrointestinal bio-barriers. The aim was to explore the potential applications 
      of bile acid transporter mediated the self-assembled hybrid nanoparticles (SHNPs) 
      of sodium taurocholate (STC) and polyvinyl caprolactam-polyvinyl 
      acetate-polyethylene glycol (Soluplus) for augmenting the oral delivery of poorly 
      water-soluble drugs. Felodipine (FLDP) was chosen as a model drug. The 
      self-assembly of STC with Soluplus to load FLDP and the microstructure of the 
      SHNPs were confirmed using molecular simulation, STC determination by high 
      performance liquid chromatography (HPLC) and transmission electron microscope. 
      Results showed that STC was integrated with Soluplus on the surface of 
      nanoparticles by hydrophobic interactions. The permeability of FLDP loaded 
      STC/Soluplus SHNPs was STC dependent in the ileum, which was inhibited by the 
      higher concentrations of STC and the inhibitor of apical sodium-dependent bile 
      acid transporter (ASBT). STC/Soluplus (1:9) SHNPs significantly improved the drug 
      loading of FLDP, achieved the highest permeability of FLDP and realized 1.6-fold 
      of the area under the curve (AUC) of Soluplus self-assembled nanoparticles 
      (SNPs). A water-quenching fluorescent probe P4 was loaded into the STC/Soluplus 
      SHNPs, which verified that the SHNPs were transferred intactly across the ileum. 
      In conclusion, STC/Soluplus SHNPs via ASBT are a potential strategy for enhancing 
      the oral bioavailability of poorly water-soluble drugs.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Zhang, Shujuan
AU  - Zhang S
AD  - College of Pharmaceutical Sciences, Zhejiang University of Technology, 18 
      Chaowang Road, Hangzhou 310032, PR China.
FAU - Cui, Dongmei
AU  - Cui D
AD  - College of Pharmaceutical Sciences, Zhejiang University of Technology, 18 
      Chaowang Road, Hangzhou 310032, PR China.
FAU - Xu, Jiawei
AU  - Xu J
AD  - College of Pharmaceutical Sciences, Zhejiang University of Technology, 18 
      Chaowang Road, Hangzhou 310032, PR China.
FAU - Wang, Jiandong
AU  - Wang J
AD  - College of Pharmaceutical Sciences, Zhejiang University of Technology, 18 
      Chaowang Road, Hangzhou 310032, PR China.
FAU - Wei, Qi
AU  - Wei Q
AD  - College of Pharmaceutical Sciences, Zhejiang University of Technology, 18 
      Chaowang Road, Hangzhou 310032, PR China.
FAU - Xiong, Subin
AU  - Xiong S
AD  - College of Pharmaceutical Sciences, Zhejiang University of Technology, 18 
      Chaowang Road, Hangzhou 310032, PR China; Shanghai Anbison Laboratory Co., Ltd., 
      889 Yishan Road, Shanghai 200233, PR China. Electronic address: 
      sbxiong@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20200205
PL  - Netherlands
TA  - Int J Pharm
JT  - International journal of pharmaceutics
JID - 7804127
RN  - 0 (Drug Carriers)
RN  - 0 (Organic Anion Transporters, Sodium-Dependent)
RN  - 0 (Polyvinyls)
RN  - 0 (Symporters)
RN  - 0 (polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer)
RN  - 145420-23-1 (sodium-bile acid cotransporter)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 5E090O0G3Z (Taurocholic Acid)
RN  - OL961R6O2C (Felodipine)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Area Under Curve
MH  - Drug Carriers/*chemistry
MH  - Drug Compounding/methods
MH  - Drug Liberation
MH  - Felodipine/*administration & dosage/pharmacokinetics
MH  - Hydrophobic and Hydrophilic Interactions
MH  - Male
MH  - Mice
MH  - Nanoparticles/*chemistry
MH  - Organic Anion Transporters, Sodium-Dependent/*chemistry
MH  - Permeability
MH  - Polyethylene Glycols/chemistry
MH  - Polyvinyls/chemistry
MH  - Rats
MH  - Symporters/*chemistry
MH  - Taurocholic Acid/*chemistry
OTO - NOTNLM
OT  - ASBT
OT  - Felodipine
OT  - P4
OT  - Self-assembled hybrid nanoparticles
OT  - Sodium taurocholate
OT  - Soluplus
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/02/09 06:00
MHDA- 2020/12/29 06:00
CRDT- 2020/02/09 06:00
PHST- 2019/09/19 00:00 [received]
PHST- 2020/02/02 00:00 [revised]
PHST- 2020/02/04 00:00 [accepted]
PHST- 2020/02/09 06:00 [pubmed]
PHST- 2020/12/29 06:00 [medline]
PHST- 2020/02/09 06:00 [entrez]
AID - S0378-5173(20)30104-6 [pii]
AID - 10.1016/j.ijpharm.2020.119120 [doi]
PST - ppublish
SO  - Int J Pharm. 2020 Apr 15;579:119120. doi: 10.1016/j.ijpharm.2020.119120. Epub 
      2020 Feb 5.