PMID- 32035991
OWN - NLM
STAT- MEDLINE
DCOM- 20201026
LR  - 20201026
IS  - 1532-8392 (Electronic)
IS  - 0046-8177 (Linking)
VI  - 98
DP  - 2020 Apr
TI  - Pathologic grading of mucoepidermoid carcinomas of the salivary gland and its 
      effect on clinicopathologic follow-up: an institutional experience.
PG  - 89-97
LID - S0046-8177(20)30019-8 [pii]
LID - 10.1016/j.humpath.2020.02.001 [doi]
AB  - Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumor. 
      Differences inprognosis can be noted owing to the tumor grade determined using 
      multiple grading schemes (2-tier: low- and high-grade vs. 3-tier: low-, 
      intermediate-, and high-grade). We studied clinicopathologic features of MEC 
      using a 3-tier grading system and retrospectively categorized cytologic diagnoses 
      as per the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC).A 
      total of 69 cases of MEC were identified, and most were seen in the parotid 
      gland. Aggressive clinical behavior was seen in high-grade MEC compared with 
      intermediate- and low-grade MEC. By fluorescence in situ hybridization (FISH) 
      analysis, MAML2 rearrangements were seen in 78% of cases.The MSRSGC 
      subcategorized the majority (63.8%) of MEC as salivary gland neoplasm of 
      uncertain malignant potential, suspicious for malignancy, or malignant. 
      Clustering intermediate- with low-grade cases did not significantly impact the 
      clinical behavior. Both high-grade and oncocytic MEC can be MAML2 FISH negative.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Shafique, Khurram
AU  - Shafique K
AD  - University of Pennsylvania Medical Center, Philadelphia, PA, 19104, USA.
FAU - Zhang, Paul J
AU  - Zhang PJ
AD  - University of Pennsylvania Medical Center, Philadelphia, PA, 19104, USA.
FAU - Montone, Kathleen T
AU  - Montone KT
AD  - University of Pennsylvania Medical Center, Philadelphia, PA, 19104, USA.
FAU - Song, Sharon
AU  - Song S
AD  - University of Pennsylvania Medical Center, Philadelphia, PA, 19104, USA.
FAU - Livolsi, Virginia A
AU  - Livolsi VA
AD  - University of Pennsylvania Medical Center, Philadelphia, PA, 19104, USA.
FAU - Baloch, Zubair
AU  - Baloch Z
AD  - University of Pennsylvania Medical Center, Philadelphia, PA, 19104, USA. 
      Electronic address: baloch@pennmedicine.upenn.edu.
LA  - eng
PT  - Journal Article
DEP - 20200206
PL  - United States
TA  - Hum Pathol
JT  - Human pathology
JID - 9421547
RN  - 0 (ANO1 protein, human)
RN  - 0 (Anoctamin-1)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (MAML2 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Trans-Activators)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anoctamin-1/analysis
MH  - Biomarkers, Tumor/analysis/genetics
MH  - Biopsy
MH  - Carcinoma, Mucoepidermoid/chemistry/genetics/*pathology
MH  - Female
MH  - Gene Rearrangement
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - *Neoplasm Grading
MH  - Neoplasm Proteins/analysis
MH  - Predictive Value of Tests
MH  - Retrospective Studies
MH  - Salivary Gland Neoplasms/chemistry/genetics/*pathology
MH  - Trans-Activators/genetics
MH  - Young Adult
OTO - NOTNLM
OT  - Grading
OT  - MAML2 FISH
OT  - Milan System for Reporting Salivary Gland Cytopathology (MSRSGC)
OT  - Mucoepidermoid carcinoma
OT  - Salivary gland neoplasm
EDAT- 2020/02/10 06:00
MHDA- 2020/10/27 06:00
CRDT- 2020/02/10 06:00
PHST- 2019/12/27 00:00 [received]
PHST- 2020/01/24 00:00 [revised]
PHST- 2020/02/03 00:00 [accepted]
PHST- 2020/02/10 06:00 [pubmed]
PHST- 2020/10/27 06:00 [medline]
PHST- 2020/02/10 06:00 [entrez]
AID - S0046-8177(20)30019-8 [pii]
AID - 10.1016/j.humpath.2020.02.001 [doi]
PST - ppublish
SO  - Hum Pathol. 2020 Apr;98:89-97. doi: 10.1016/j.humpath.2020.02.001. Epub 2020 Feb 
      6.