PMID- 32036367
OWN - NLM
STAT- MEDLINE
DCOM- 20210811
LR  - 20210811
IS  - 1423-0259 (Electronic)
IS  - 0030-3747 (Linking)
VI  - 63
IP  - 6
DP  - 2020
TI  - Comparison of Long-Term Automated Retinal Layer Segmentation Analysis of the 
      Macula between Silicone Oil and Gas Tamponade after Vitrectomy for Rhegmatogenous 
      Retinal Detachment.
PG  - 524-532
LID - 10.1159/000506382 [doi]
AB  - PURPOSE: To identify long-term changes in individual retinal layer thickness 
      using automated retinal layer segmentation analysis on high-resolution 
      spectral-domain optical coherence tomography (SD-OCT) scans of eyes with 
      macula-off rhegmatogenous retinal detachment (RRD) treated with vitreoretinal 
      surgery (VRS) and gas or silicone oil tamponade and having single-operation 
      success. METHODS: A total of 58 patients operated on by VRS for RRD and followed 
      up for 12 months were imaged by SD-OCT. The patients with retinal diseases such 
      as an epiretinal membrane or cystic macular edema in the operated and fellow eyes 
      were excluded. The thicknesses of the retinal nerve fiber layer (RNFL), ganglion 
      cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer 
      plexiform layer (OPL), outer nuclear layer (ONL), photoreceptor layer, and 
      retinal pigment epithelium were compared to those of the fellow eyes after the 
      12-month follow-up. Thickness changes in individual layers were quantitatively 
      analyzed in the operated and fellow eyes and correlated with the type of 
      tamponade used in the surgery. RESULTS: Spectralis OCT automated segmentation 
      software was used for the retinal layer analysis. There were 22 females and 36 
      males. Their mean age was 60.7 +/- 11.2 years. The mean central macular thickness 
      was 214.3 +/- 29.5 microm in the operated and 229.7 +/- 21.7 microm in the fellow eyes (p = 
      0.008). There was a statistically significant difference between the operated and 
      the healthy fellow eyes in the following layers: the RNFL (p = 0.017), GCL (p = 
      0.02), INL (p = 0.005), and ONL (p = 0.008) in the central foveal area; the RNFL 
      (p < 0.001), INL (p = 0.017), and ONL (p = 0.022) in the perifoveal ring; and the 
      RNFL (p < 0.001), IPL (p = 0.042), INL (p = 0.001), and OPL (p = 0.001) in the 
      peripheral ring. The logMAR best corrected visual acuities were 2.51 +/- 0.68 and 
      2.69 +/- 0.62 at baseline and 0.60 +/- 0.38 and 0.50 +/- 0.38 at month 12 in the 
      silicone oil tamponade (n = 28) and the gas tamponade (n = 30) group (p = 0.52 
      and p = 0.21, respectively). The foveal GCL, OPL, and ONL and the perifoveal GCL 
      and IPL were statistically significantly thinner in the silicone oil tamponade 
      group (p = 0.01, p = 0.046, p = 0.024, p = 0.006, and p = 0.011, respectively). 
      CONCLUSIONS: Significant changes were observed in the retinal layers after VRS 
      for RRD. Individual retinal layers seem to be affected 1 year after VRS for RRD. 
      The type of tamponade can influence the thickness of the retinal layers. The 
      thickness of the retinal layers was significantly preserved in eyes treated with 
      gas tamponade when compared to those treated with silicone oil tamponade in the 
      long term. Further studies are needed to validate our results.
CI  - (c) 2020 S. Karger AG, Basel.
FAU - Inan, Sibel
AU  - Inan S
AD  - Department of Ophthalmology, Afyonkarahisar Health Sciences University Medical 
      School, Afyonkarahisar, Turkey, drinan33@gmail.com.
AD  - formerly at Department of Ophthalmology, Afyon Kocatepe University Medical 
      School, Afyonkarahisar, Turkey, drinan33@gmail.com.
FAU - Polat, Onur
AU  - Polat O
AD  - Department of Ophthalmology, Afyon State Hospital, Afyonkarahisar, Turkey.
AD  - formerly at Department of Ophthalmology, Afyon Kocatepe University Medical 
      School, Afyonkarahisar, Turkey.
FAU - Ozcan, Serkan
AU  - Ozcan S
AD  - Department of Ophthalmology, Idil State Hospital, Sirnak, Turkey.
AD  - formerly at Department of Ophthalmology, Afyon Kocatepe University Medical 
      School, Afyonkarahisar, Turkey.
FAU - Inan, Umit Ubeyt
AU  - Inan UU
AD  - Department of Ophthalmology, ParkHayat Hospital, Afyonkarahisar, Turkey.
AD  - formerly at Department of Ophthalmology, Afyon Kocatepe University Medical 
      School, Afyonkarahisar, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20200210
PL  - Switzerland
TA  - Ophthalmic Res
JT  - Ophthalmic research
JID - 0267442
RN  - 0 (Silicone Oils)
SB  - IM
MH  - Endotamponade/*methods
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Macula Lutea/diagnostic imaging/*surgery
MH  - Male
MH  - Middle Aged
MH  - Retinal Detachment/diagnosis/*surgery
MH  - Retinal Ganglion Cells/pathology
MH  - Retinal Pigment Epithelium/pathology
MH  - Retrospective Studies
MH  - Silicone Oils/*pharmacology
MH  - Tomography, Optical Coherence/methods
MH  - *Visual Acuity
MH  - Vitrectomy/*methods
OTO - NOTNLM
OT  - Automated retinal layer segmentation analysis
OT  - Gas tamponade
OT  - Macula
OT  - Rhegmatogenous retinal detachment
OT  - Silicone oil tamponade
OT  - Vitrectomy
EDAT- 2020/02/10 06:00
MHDA- 2021/08/12 06:00
CRDT- 2020/02/10 06:00
PHST- 2019/03/17 00:00 [received]
PHST- 2020/02/02 00:00 [accepted]
PHST- 2020/02/10 06:00 [pubmed]
PHST- 2021/08/12 06:00 [medline]
PHST- 2020/02/10 06:00 [entrez]
AID - 000506382 [pii]
AID - 10.1159/000506382 [doi]
PST - ppublish
SO  - Ophthalmic Res. 2020;63(6):524-532. doi: 10.1159/000506382. Epub 2020 Feb 10.