PMID- 32036371
OWN - NLM
STAT- MEDLINE
DCOM- 20210623
LR  - 20210623
IS  - 1423-0259 (Electronic)
IS  - 0030-3747 (Linking)
VI  - 63
IP  - 5
DP  - 2020
TI  - The Effect of Glycemia on Choroidal Thickness in Different Stages of Diabetic 
      Retinopathy.
PG  - 474-482
LID - 10.1159/000506381 [doi]
AB  - OBJECTIVE: The purpose of this study was to evaluate the influence of renal and 
      glycemic parameters on choroidal thickness (CT) in patients with diabetes with 
      and without diabetic retinopathy (DR). METHODS: This cross-sectional study 
      included patients with and without diabetes. Patients underwent comprehensive 
      ocular examination. CT was obtained using spectral-domain optical coherence 
      tomography (SD-OCT) with enhanced depth imaging (EDI) mode. Clinical parameters 
      were body mass index, mean arterial pressure, glycated hemoglobin, fasting plasma 
      glucose, estimated glomerular filtration rate, and capillary plasma glucose (CPG) 
      a few minutes before EDI-SD-OCT. RESULTS: The study included 275 participants: 42 
      with diabetes and no DR, 43 with mild nonproliferative diabetic retinopathy 
      (NPDR), 46 with moderate NPDR, 39 with severe NPDR, 24 with proliferative 
      diabetic retinopathy (PDR), 40 with previous panretinal photocoagulation (PRP) 
      treatment for DR, and 41 without diabetes. The diabetic patients had thinner 
      subfoveal CT than the nondiabetic participants (280.5 +/- 83.4 vs. 327.1 +/- 48.8 microm, 
      p < 0.001). After multivariable adjustment, CT was significantly correlated with 
      age, DR stage, and CPG. In patients with mild and moderate NPDR, a higher level 
      of CPG was associated with thicker CT. This relationship was not found in 
      patients with PDR. CONCLUSION: CPG had the strongest correlation with CT in 
      patients with NPDR (mild, moderate, and severe), but not in PDR and PRP PDR 
      patients. Our study suggests that the glucose level at the time of the test 
      should be aggregated to other systemic and ocular parameters, such as age and 
      axial length, when studying the choroid using SD-OCT.
CI  - (c) 2020 S. Karger AG, Basel.
FAU - Abalem, Maria Fernanda
AU  - Abalem MF
AD  - Division of Ophthalmology, University of Sao Paulo Medical School, Sao Paulo, 
      Brazil, mabalemd@med.umich.edu.
AD  - Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University 
      of Michigan, Ann Arbor, Michigan, USA, mabalemd@med.umich.edu.
FAU - Nazareth Santos Veloso, Helen
AU  - Nazareth Santos Veloso H
AD  - Division of Ophthalmology, University of Sao Paulo Medical School, Sao Paulo, 
      Brazil.
FAU - Garcia, Rafael
AU  - Garcia R
AD  - Division of Ophthalmology, University of Sao Paulo Medical School, Sao Paulo, 
      Brazil.
FAU - Chen, Xing Dong
AU  - Chen XD
AD  - Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University 
      of Michigan, Ann Arbor, Michigan, USA.
FAU - Carricondo, Pedro C
AU  - Carricondo PC
AD  - Division of Ophthalmology, University of Sao Paulo Medical School, Sao Paulo, 
      Brazil.
FAU - Cabral Zacharias, Leandro
AU  - Cabral Zacharias L
AD  - Division of Ophthalmology, University of Sao Paulo Medical School, Sao Paulo, 
      Brazil.
FAU - Preti, Rony C
AU  - Preti RC
AD  - Division of Ophthalmology, University of Sao Paulo Medical School, Sao Paulo, 
      Brazil.
LA  - eng
PT  - Journal Article
DEP - 20200210
PL  - Switzerland
TA  - Ophthalmic Res
JT  - Ophthalmic research
JID - 0267442
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Biomarkers/blood
MH  - Blood Glucose/*metabolism
MH  - Capillaries/diagnostic imaging
MH  - Choroid/*diagnostic imaging
MH  - Cross-Sectional Studies
MH  - Diabetic Retinopathy/blood/*diagnosis
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Tomography, Optical Coherence/*methods
MH  - *Visual Acuity
MH  - Vitreous Body/*diagnostic imaging
OTO - NOTNLM
OT  - Choroid
OT  - Diabetes
OT  - Diabetic retinopathy
OT  - Glucose
OT  - Optical coherence tomography
OT  - Retina
EDAT- 2020/02/10 06:00
MHDA- 2021/06/24 06:00
CRDT- 2020/02/10 06:00
PHST- 2019/11/08 00:00 [received]
PHST- 2020/02/02 00:00 [accepted]
PHST- 2020/02/10 06:00 [pubmed]
PHST- 2021/06/24 06:00 [medline]
PHST- 2020/02/10 06:00 [entrez]
AID - 000506381 [pii]
AID - 10.1159/000506381 [doi]
PST - ppublish
SO  - Ophthalmic Res. 2020;63(5):474-482. doi: 10.1159/000506381. Epub 2020 Feb 10.