PMID- 32036837
OWN - NLM
STAT- MEDLINE
DCOM- 20201217
LR  - 20201217
IS  - 1681-7168 (Electronic)
IS  - 1022-386X (Linking)
VI  - 30
IP  - 2
DP  - 2020 Feb
TI  - Rapamycin-eluting Single and Double Stenting on Serum Markers in Coronary 
      Bifurcation Lesions.
PG  - 222-224
LID - 10.29271/jcpsp.2020.02.222 [doi]
AB  - The objective of study was to compare effects of rapamycin-eluting single and 
      double stenting on serum markers like high sensitivity C-reactive protein 
      (hs-CRP), tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), interleukin 
      8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) in patients with coronary 
      bifurcation lesions. It was an experimental study carried out from April 2016 to 
      July 2017. One hundred and twenty-six patients were divided into two equal groups 
      according to different treatment regimens. Group A was treated with 
      rapamycin-eluting single stenting and group B with rapamycin-eluting double 
      stenting. Three months after operation, hs-CRP, TNF-alpha, IL-6, IL-8 and MCP-1 
      levels in group B were lower than those in group A (p=0.010, p <0.001, p <0.001, 
      p <0.001 and p <0.001, respectively). After one year of follow-up, rate of 
      intrasegmental restenosis of branch vessels was higher in group A than in group B 
      (p=0.011). Compared with rapamycin-eluting single stenting, rapamycin-eluting 
      double stenting may regulate more effectively the above serum markers levels, 
      reduce the incidence of intrasegmental restenosis of branch vessels.
FAU - Wang, Jintao
AU  - Wang J
AD  - Department of Cardiology, Lanzhou University Second Hospital, China.
FAU - Zeng, Yihua
AU  - Zeng Y
AD  - Department of Internal Medicine, Gansu Province Hospital Rehabilitation Centre, 
      Lanzhou, China.
FAU - Zhu, Hai
AU  - Zhu H
AD  - Department of Cardiology, Gansu Provincial Hospital, China.
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - J Coll Physicians Surg Pak
JT  - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
JID - 9606447
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 0 (Immunosuppressive Agents)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Aged
MH  - Angioplasty, Balloon, Coronary/*methods
MH  - Biomarkers
MH  - C-Reactive Protein/*metabolism
MH  - Chemokine CCL2/*blood
MH  - Coronary Angiography
MH  - Coronary Stenosis/blood/diagnosis/*surgery
MH  - Coronary Vessels/diagnostic imaging/*surgery
MH  - Cytokines/*blood
MH  - Drug-Eluting Stents
MH  - Female
MH  - Humans
MH  - Immunosuppressive Agents/pharmacology
MH  - Male
MH  - Middle Aged
MH  - Sirolimus/*pharmacology
EDAT- 2020/02/11 06:00
MHDA- 2020/12/18 06:00
CRDT- 2020/02/11 06:00
PHST- 2018/11/29 00:00 [received]
PHST- 2019/07/04 00:00 [accepted]
PHST- 2020/02/11 06:00 [entrez]
PHST- 2020/02/11 06:00 [pubmed]
PHST- 2020/12/18 06:00 [medline]
AID - 040579197 [pii]
AID - 10.29271/jcpsp.2020.02.222 [doi]
PST - ppublish
SO  - J Coll Physicians Surg Pak. 2020 Feb;30(2):222-224. doi: 
      10.29271/jcpsp.2020.02.222.