PMID- 32037478
OWN - NLM
STAT- MEDLINE
DCOM- 20201214
LR  - 20240328
IS  - 2196-5412 (Electronic)
IS  - 2196-5412 (Linking)
VI  - 7
IP  - 1
DP  - 2020 Mar
TI  - Synthetic Chemicals and Cardiometabolic Health Across the Life Course Among 
      Vulnerable Populations: a Review of the Literature from 2018 to 2019.
PG  - 30-47
LID - 10.1007/s40572-020-00265-6 [doi]
AB  - PURPOSE OF REVIEW: Although vulnerable populations are disproportionately exposed 
      to synthetic chemicals with endocrine disrupting properties, few recent reviews 
      have summarized the impact of synthetic chemicals on cardiometabolic health among 
      these groups. RECENT FINDINGS: Of 37 eligible epidemiological studies among 
      vulnerable populations published between January 2018 and April 2019 in which 
      over half were prospective, the most investigated populations were pregnant women 
      and children. Racial/ethnic minorities, individuals of low socioeconomic status 
      (SES), and those occupationally exposed were studied the least. The most studied 
      persistent organic pollutants (POPs) were per-/poly-fluoroalkyl substances 
      (PFAS), and the most studied non-POPs were phenols. Across chemical classes, 
      studies found certain POPs (e.g., PFAS) and non-POPs (i.e., phenols, phthalates, 
      and parabens) to be associated with gestational diabetes and dysregulated glucose 
      metabolism. Results for other cardiometabolic health outcomes were inconsistent 
      but suggested certain chemicals may negatively affect cardiometabolic health. 
      Synthetic chemicals likely adversely affect cardiometabolic health, but current 
      findings were inconclusive. Few recent studies focused on racial/ethnic 
      minorities, low SES, and occupationally exposed populations. To address poor 
      cardiometabolic health and related disparities, more studies across vulnerable 
      populations are warranted.
FAU - Gaston, Symielle A
AU  - Gaston SA
AUID- ORCID: 0000-0001-9495-1592
AD  - Epidemiology Branch, National Institute of Environmental Health Sciences, 
      Department of Health and Human Services, National Institutes of Health, 111 TW 
      Alexander Drive, MD A3-05, Research Triangle Park, NC, 27709, USA.
FAU - Birnbaum, Linda S
AU  - Birnbaum LS
AUID- ORCID: 0000-0001-5429-5658
AD  - Office of the Director, National Institute of Environmental Health Sciences and 
      the National Toxicology Program, Department of Health and Human Services, 
      National Institutes of Health, Research Triangle Park, NC, USA.
FAU - Jackson, Chandra L
AU  - Jackson CL
AUID- ORCID: 0000-0002-0915-8272
AD  - Epidemiology Branch, National Institute of Environmental Health Sciences, 
      Department of Health and Human Services, National Institutes of Health, 111 TW 
      Alexander Drive, MD A3-05, Research Triangle Park, NC, 27709, USA. 
      Chandra.Jackson@nih.gov.
AD  - Intramural Program, National Institute on Minority Health and Health Disparities, 
      Department of Health and Human Services, National Institutes of Health, Bethesda, 
      MD, USA. Chandra.Jackson@nih.gov.
LA  - eng
GR  - ZIA ES103325/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Review
PL  - Switzerland
TA  - Curr Environ Health Rep
JT  - Current environmental health reports
JID - 101629387
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Parabens)
RN  - 0 (Phenols)
RN  - 0 (Phthalic Acids)
RN  - 6O7F7IX66E (phthalic acid)
SB  - IM
MH  - Cardiovascular Diseases/chemically induced/epidemiology
MH  - Endocrine Disruptors/toxicity
MH  - Environmental Pollutants/*toxicity
MH  - Female
MH  - Health/statistics & numerical data
MH  - Humans
MH  - Parabens/toxicity
MH  - Phenols/toxicity
MH  - Phthalic Acids/toxicity
MH  - Pregnancy
MH  - Prospective Studies
MH  - Vulnerable Populations/*statistics & numerical data
PMC - PMC7187897
MID - NIHMS1558772
OTO - NOTNLM
OT  - Cardiovascular diseases
OT  - Endocrine disruptors
OT  - Metabolic diseases
OT  - Minority health
OT  - Pregnancy complications
OT  - Vulnerable populations
COIS- Conflict of Interest: SA. Gaston, LS. Birnbaum, and CL. Jackson declare that they 
      have no conflict of interest.
EDAT- 2020/02/11 06:00
MHDA- 2020/12/15 06:00
PMCR- 2021/03/01
CRDT- 2020/02/11 06:00
PHST- 2020/02/11 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2020/02/11 06:00 [entrez]
PHST- 2021/03/01 00:00 [pmc-release]
AID - 10.1007/s40572-020-00265-6 [pii]
AID - 10.1007/s40572-020-00265-6 [doi]
PST - ppublish
SO  - Curr Environ Health Rep. 2020 Mar;7(1):30-47. doi: 10.1007/s40572-020-00265-6.