PMID- 32037646 OWN - NLM STAT- MEDLINE DCOM- 20200730 LR - 20250530 IS - 1600-0838 (Electronic) IS - 0905-7188 (Print) IS - 0905-7188 (Linking) VI - 30 IP - 5 DP - 2020 May TI - Estimated cardiorespiratory fitness in childhood and cardiometabolic health in adulthood: 1970 British Cohort Study. PG - 932-938 LID - 10.1111/sms.13637 [doi] AB - BACKGROUND: Associations of cardiorespiratory fitness in childhood and adulthood with adult cardiometabolic risk factors are poorly understood, not least because of the paucity of studies. OBJECTIVES: We investigated associations between nonexercise testing cardiorespiratory fitness (NETCRF) in childhood/adulthood and cardiometabolic risk factors in adulthood. METHODS: Based on an established algorithm comprising gender, age, body mass index, resting heart rate, and self-reported physical activity at age 10, we computed NETCRF. Risk factors were assessed at age 46 in 5009 participants when NETCRF was again calculated. Linear regression was used to summarize associations between NETCRF in childhood and risk factors in adulthood and, additionally, the relationship between NETCRF in adulthood and risk factors in adulthood after adjusting for childhood NETCRF. RESULTS: Inconsistent associations were observed between childhood NETCRF and adult risk factors. NETCRF in adulthood was associated with blood pressure [-5.8 (-6.7, -4.9)], glycated hemoglobin [-3.41 (-4.06, -2.76)], total cholesterol [-0.16 (-0.24, -0.08)], HDL cholesterol [0.19 (0.16, 0.22)], triglycerides [-0.68 (-0.85, -0.50)], and C-reactive protein [-0.29 (-0.35, -0.22)] in adult males. Similar associations were observed in adult females. Compared to those with low estimated fitness in both childhood and adulthood, participants with low fitness in childhood and high fitness in adulthood had a lower risk of two or more cardiometabolic risk factors (odds ratio: 0.25; 95% confidence interval: 0.19, 0.31). CONCLUSION: Associations between estimated fitness and risk factors are stronger in adulthood than from childhood to adulthood. Adults with previously sedentary childhoods may still gain benefits from improving their fitness. CI - (c) 2020 The Authors. Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd. FAU - Hamer, Mark AU - Hamer M AUID- ORCID: 0000-0002-8726-7992 AD - Division of Surgery & Interventional Science, Faculty of Medical Sciences, Institute Sport Exercise Health, University College London, London, UK. FAU - O'Donovan, Gary AU - O'Donovan G AD - Facultad de Medicina, Universidad de los Andes, Bogota, Colombia. FAU - Batty, G David AU - Batty GD AD - Department of Epidemiology & Public Health, University College London, London, UK. AD - School of Biological & Population Health Sciences, Oregon State University, Corvallis, OR, USA. FAU - Stamatakis, Emmanuel AU - Stamatakis E AD - Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia. AD - School of Public Health, Prevention Research Collaboration, The University of Sydney, Sydney, NSW, Australia. LA - eng GR - SP/15/6/31397/BHF_/British Heart Foundation/United Kingdom GR - RES-579-47-0001/Economic Social Research Council and Medical Research Council/ PT - Journal Article DEP - 20200226 PL - Denmark TA - Scand J Med Sci Sports JT - Scandinavian journal of medicine & science in sports JID - 9111504 RN - 97C5T2UQ7J (Cholesterol) SB - IM MH - Blood Pressure MH - *Cardiorespiratory Fitness MH - Cardiovascular Diseases/*epidemiology MH - Child MH - Cholesterol/blood MH - Cohort Studies MH - England/epidemiology MH - *Exercise MH - Female MH - Health Surveys MH - Humans MH - Male MH - Middle Aged MH - Risk Factors MH - Scotland/epidemiology MH - Wales/epidemiology PMC - PMC7187251 OTO - NOTNLM OT - cohort OT - fitness OT - metabolic OT - population COIS- None declared. EDAT- 2020/02/11 06:00 MHDA- 2020/07/31 06:00 PMCR- 2020/04/28 CRDT- 2020/02/11 06:00 PHST- 2019/10/15 00:00 [received] PHST- 2020/01/22 00:00 [revised] PHST- 2020/02/04 00:00 [accepted] PHST- 2020/02/11 06:00 [pubmed] PHST- 2020/07/31 06:00 [medline] PHST- 2020/02/11 06:00 [entrez] PHST- 2020/04/28 00:00 [pmc-release] AID - SMS13637 [pii] AID - 10.1111/sms.13637 [doi] PST - ppublish SO - Scand J Med Sci Sports. 2020 May;30(5):932-938. doi: 10.1111/sms.13637. Epub 2020 Feb 26.