PMID- 32038086
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 0974-1208 (Print)
IS  - 1998-4766 (Electronic)
IS  - 1998-4766 (Linking)
VI  - 12
IP  - 4
DP  - 2019 Oct-Dec
TI  - India's First Child using PGT-M, PGT-A and HLA Matching for Helping a Sibling 
      having beta-Thalassemia Major.
PG  - 341-344
LID - 10.4103/jhrs.JHRS_50_19 [doi]
AB  - beta-thalassemia is a common single-gene disorder in India, with hematopoietic stem 
      cell transplantation (HSCT) being the only cure. HSCT with matched unrelated 
      donor is less successful, whereas finding a human leukocyte antigen (HLA)-matched 
      related donor is difficult. Preimplantation genetic testing for monogenic 
      diseases (PGT-M) with HLA matching is a novel option to have a matched sibling 
      for HSCT for couples having an affected child. We present the first such case 
      report in India. A couple, both carriers of beta-thalassemia and having an affected 
      son, underwent PGT-M with HLA matching combined with preimplantation genetic 
      testing for aneuploidies of embryos to have a beta - thalassemia-free child. This 
      resulted in birth of a 10/10 HLA-matched sibling.
CI  - Copyright: (c) 2019 Journal of Human Reproductive Sciences.
FAU - Banker, Jwal M
AU  - Banker JM
AD  - NOVA IVI Fertility, Ahmedabad, Gujarat, India.
FAU - Arora, Parul
AU  - Arora P
AD  - NOVA IVI Fertility, Ahmedabad, Gujarat, India.
FAU - Khajuria, Rajni
AU  - Khajuria R
AD  - Igenomix, New Delhi, India.
FAU - Banker, Manish
AU  - Banker M
AD  - NOVA IVI Fertility, Ahmedabad, Gujarat, India.
LA  - eng
PT  - Case Reports
DEP - 20191217
PL  - India
TA  - J Hum Reprod Sci
JT  - Journal of human reproductive sciences
JID - 101473512
PMC - PMC6937767
OTO - NOTNLM
OT  - Human leukocyte antigen matching
OT  - hematopoietic stem cell transplantation
OT  - preimplantation genetic testing for aneuploidies
OT  - preimplantation genetic testing for monogenic diseases
OT  - beta-thalassemia
COIS- There are no conflicts of interest.
EDAT- 2020/02/11 06:00
MHDA- 2020/02/11 06:01
PMCR- 2019/10/01
CRDT- 2020/02/11 06:00
PHST- 2019/04/07 00:00 [received]
PHST- 2019/09/11 00:00 [revised]
PHST- 2019/11/01 00:00 [accepted]
PHST- 2020/02/11 06:00 [entrez]
PHST- 2020/02/11 06:00 [pubmed]
PHST- 2020/02/11 06:01 [medline]
PHST- 2019/10/01 00:00 [pmc-release]
AID - JHRS-12-341 [pii]
AID - 10.4103/jhrs.JHRS_50_19 [doi]
PST - ppublish
SO  - J Hum Reprod Sci. 2019 Oct-Dec;12(4):341-344. doi: 10.4103/jhrs.JHRS_50_19. Epub 
      2019 Dec 17.