PMID- 32038102 OWN - NLM STAT- MEDLINE DCOM- 20201102 LR - 20201102 IS - 1449-1907 (Electronic) IS - 1449-1907 (Linking) VI - 17 IP - 2 DP - 2020 TI - Circulating fatty acid-binding protein 1 (FABP1) and nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus. PG - 182-190 LID - 10.7150/ijms.40417 [doi] AB - Background: Fatty acid-binding protein 1 (FABP1) (also known as liver-type fatty acid-binding protein or LFABP) is a protein that is mainly expressed in the liver, and is associated with hepatocyte injury in acute transplant rejection. Reduced levels of FABP1 in mice livers have been shown to be effective against nonalcoholic fatty liver disease (NAFLD). In this study, we investigated the association between plasma FABP1 levels and NAFLD in patients with type 2 diabetes mellitus (T2DM). Methods: We enrolled 267 T2DM patients. Clinical and biochemical parameters were measured. The severity of NAFLD was assessed by ultrasound. FABP1 levels were determined using by enzyme-linked immunosorbent assays. Results: FABP1 levels were higher in patients with overt NAFLD, defined as more than a moderate degree of fatty liver compared to those without NAFLD. Age- and sex-adjusted analysis of FABP1 showed positive associations with body mass index (BMI), waist circumference, homeostasis model assessment estimate of beta-cell function, creatinine, and fatty liver index, but showed negative associations with albumin and estimated glomerular filtration rate (eGFR). The odds ratio (OR) for the risk of overt NAFLD with increasing levels of sex-specific FABP1 was significantly increased (OR 2.63 [95% CI 1.30-5.73] vs. 4.94 [2.25-11.48]). The OR in the second and third tertiles of FABP1 remained significant after adjustments for BMI, triglycerides, high-density lipoprotein cholesterol, HbA1C, homeostasis model assessment estimate of insulin resistance, white blood cell count, hepatic enzymes, and eGFR. Conclusion: Our results indicate that FABP1 may play a role in the pathogenesis of NAFLD in patients with T2DM. CI - (c) The author(s). FAU - Lu, Yung-Chuan AU - Lu YC AD - Division of Endocrinology and Metabolism, E-Da Hospital, Kaohsiung, 82445 Taiwan. AD - School of Medicine, College of Medicine, I-Shou University, Kaohsiung, 82445 Taiwan. FAU - Chang, Chi-Chang AU - Chang CC AD - Department of Obstetrics & Gynecology, E-Da Hospital, Kaohsiung, 82445 Taiwan. AD - School of Medicine, College of Medicine, I-Shou University, Kaohsiung, 82445 Taiwan. AD - Department of Obstetrics & Gynecology, E-Da Dachang Hospital, Kaohsiung 80794 Taiwan. FAU - Wang, Chao-Ping AU - Wang CP AD - Division of Cardiology, E-Da Hospital, Kaohsiung, 82445 Taiwan. AD - School of Medicine, College of Medicine, I-Shou University, Kaohsiung, 82445 Taiwan. FAU - Hung, Wei-Chin AU - Hung WC AD - Division of Cardiology, E-Da Hospital, Kaohsiung, 82445 Taiwan. AD - The School of Chinese Medicine for Post Baccalaureate, College of Medicine, I-Shou University, Kaohsiung, 82445 Taiwan. FAU - Tsai, I-Ting AU - Tsai IT AD - Departmen of Emergency, E-Da Hospital, Kaohsiung, 82445 Taiwan. AD - School of Medicine, College of Medicine, I-Shou University, Kaohsiung, 82445 Taiwan. FAU - Tang, Wei-Hua AU - Tang WH AD - Lee's Endocrinology Clinic, Pingtung, 90000 Taiwan. FAU - Wu, Cheng-Ching AU - Wu CC AD - Division of Cardiology, E-Da Hospital, Kaohsiung, 82445 Taiwan. AD - The School of Chinese Medicine for Post Baccalaureate, College of Medicine, I-Shou University, Kaohsiung, 82445 Taiwan. AD - Division of Cardiology, Department of Internal Medicine, E-Da Cancer Hospital, Kaohsiung 82445 Taiwan. FAU - Wei, Ching-Ting AU - Wei CT AD - Division of General Surgery, Department of Surgery, E-Da Hospital, Kaohsiung, 82445 Taiwan. FAU - Chung, Fu-Mei AU - Chung FM AD - Division of Cardiology, E-Da Hospital, Kaohsiung, 82445 Taiwan. FAU - Lee, Yau-Jiunn AU - Lee YJ AD - Lee's Endocrinology Clinic, Pingtung, 90000 Taiwan. FAU - Hsu, Chia-Chang AU - Hsu CC AD - Division of Gastroenterology and Hepatology, Department of Internal Medicine, E-Da Hospital, Kaohsiung, 82445 Taiwan. AD - The School of Chinese Medicine for Post Baccalaureate, College of Medicine, I-Shou University, Kaohsiung, 82445 Taiwan. AD - Health Examination Center, E-Da Dachang Hospital, Kaohsiung, Taiwan. LA - eng PT - Journal Article DEP - 20200114 PL - Australia TA - Int J Med Sci JT - International journal of medical sciences JID - 101213954 RN - 0 (FABP1 protein, human) RN - 0 (Fatty Acid-Binding Proteins) RN - 0 (Insulin) RN - AYI8EX34EU (Creatinine) SB - IM MH - Aged MH - Body Mass Index MH - Creatinine/blood MH - Diabetes Mellitus, Type 2/*blood MH - Enzyme-Linked Immunosorbent Assay MH - Fatty Acid-Binding Proteins/*blood MH - Female MH - Humans MH - Insulin/blood MH - Male MH - Middle Aged MH - Non-alcoholic Fatty Liver Disease/*blood MH - Odds Ratio MH - Waist Circumference/physiology PMC - PMC6990891 OTO - NOTNLM OT - Fatty acid-binding protein 1 OT - nonalcoholic fatty liver disease OT - type 2 diabetes mellitus COIS- Competing Interests: The authors have declared that no competing interest exists. EDAT- 2020/02/11 06:00 MHDA- 2020/11/03 06:00 PMCR- 2020/01/01 CRDT- 2020/02/11 06:00 PHST- 2019/09/17 00:00 [received] PHST- 2019/12/19 00:00 [accepted] PHST- 2020/02/11 06:00 [entrez] PHST- 2020/02/11 06:00 [pubmed] PHST- 2020/11/03 06:00 [medline] PHST- 2020/01/01 00:00 [pmc-release] AID - ijmsv17p0182 [pii] AID - 10.7150/ijms.40417 [doi] PST - epublish SO - Int J Med Sci. 2020 Jan 14;17(2):182-190. doi: 10.7150/ijms.40417. eCollection 2020.