PMID- 32038147
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240328
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 13
DP  - 2019
TI  - The Neurovascular Unit: Effects of Brain Insults During the Perinatal Period.
PG  - 1452
LID - 10.3389/fnins.2019.01452 [doi]
LID - 1452
AB  - The neurovascular unit (NVU) is a relatively recent concept in neuroscience that 
      broadly describes the relationship between brain cells and their blood vessels. 
      The NVU incorporates cellular and extracellular components involved in regulating 
      cerebral blood flow and blood-brain barrier function. The NVU within the adult 
      brain has attracted strong research interest and its structure and function is 
      well described, however, the NVU in the developing brain over the fetal and 
      neonatal period remains much less well known. One area of particular interest in 
      perinatal brain development is the impact of known neuropathological insults on 
      the NVU. The aim of this review is to synthesize existing literature to describe 
      structure and function of the NVU in the developing brain, with a particular 
      emphasis on exploring the effects of perinatal insults. Accordingly, a brief 
      overview of NVU components and function is provided, before discussion of NVU 
      development and how this may be affected by perinatal pathologies. We have 
      focused this discussion around three common perinatal insults: prematurity, acute 
      hypoxia, and chronic hypoxia. A greater understanding of processes affecting the 
      NVU in the perinatal period may enable application of targeted therapies, as well 
      as providing a useful basis for research as it expands further into this area.
CI  - Copyright (c) 2020 Bell, Miller, Castillo-Melendez and Malhotra.
FAU - Bell, Alexander H
AU  - Bell AH
AD  - Department of Paediatrics, Monash University, Melbourne, VIC, Australia.
AD  - The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, 
      Australia.
FAU - Miller, Suzanne L
AU  - Miller SL
AD  - The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, 
      Australia.
AD  - Department of Obstetrics and Gynaecology, Monash University, Melbourne, VIC, 
      Australia.
FAU - Castillo-Melendez, Margie
AU  - Castillo-Melendez M
AD  - The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, 
      Australia.
AD  - Department of Obstetrics and Gynaecology, Monash University, Melbourne, VIC, 
      Australia.
FAU - Malhotra, Atul
AU  - Malhotra A
AD  - Department of Paediatrics, Monash University, Melbourne, VIC, Australia.
AD  - The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, 
      Australia.
AD  - Monash Newborn, Monash Children's Hospital, Melbourne, VIC, Australia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200122
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC6987380
OTO - NOTNLM
OT  - astrocytes
OT  - basement membrane
OT  - blood-brain barrier
OT  - hypoxia
OT  - hypoxia-ischemia
OT  - intrauterine growth restriction
OT  - pericytes
OT  - prematurity
EDAT- 2020/02/11 06:00
MHDA- 2020/02/11 06:01
PMCR- 2019/01/01
CRDT- 2020/02/11 06:00
PHST- 2019/09/02 00:00 [received]
PHST- 2019/12/30 00:00 [accepted]
PHST- 2020/02/11 06:00 [entrez]
PHST- 2020/02/11 06:00 [pubmed]
PHST- 2020/02/11 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2019.01452 [doi]
PST - epublish
SO  - Front Neurosci. 2020 Jan 22;13:1452. doi: 10.3389/fnins.2019.01452. eCollection 
      2019.