PMID- 32038803
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1976-8257 (Print)
IS  - 2234-2753 (Electronic)
IS  - 1976-8257 (Linking)
VI  - 24
IP  - 4
DP  - 2008 Dec
TI  - Study of a BALB/c Mouse Model for Allergic Asthma.
PG  - 253-261
LID - 10.5487/TR.2008.24.4.253 [doi]
AB  - Allergic asthma is a worldwide public health problem and a major socioeconomic 
      burden disease. It is a chronic inflammatory disease marked by airway 
      eosinophilia and goblet cell hyperplasia with mucus hypersecretion. Mouse models 
      have proven as a valuable tool for studying human asthma. In the present report 
      we describe a comparison of mouse asthma models. The experiments were designed as 
      follows: Group I was injected with ovalbumin (OVA, i.p.) on day 1 and challenged 
      with 1% OVA (aerosol exposure) on days 14~21. Group II was injected on day 1, 14 
      and aerosol-immunized on days 14~21. Group III was injected on day 1, 14 and 
      immunized by 1% OVA aerosol on days 18~21. We assessed asthma induction by 
      determining the total number of white blood cells (WBC) and eosinophils as well 
      as by measuring cytokine levels in bronchoalveolar lavage fluid (BALF). In 
      addition, we evaluated the histopathological changes of the lungs and determined 
      the concentration of immunoglobulin E (IgE) in serum. Total WBC, eosinophils, Th2 
      cytokines (IL-4, IL-13) and IgE were significantly increased in group I relative 
      to the other groups. Moreover, histopathological studies show that group I mice 
      show an increase in the infiltration of inflammatory cell-in peribronchial and 
      perivascular areas as well as an overall increase in the number of 
      mucus-containing goblet cells relative to other groups. These data suggest that 
      group I can be a useful model for the study of human asthma pathobiology and the 
      evaluation of existing and novel therapeutic agents.
CI  - (c) Korean Society of Toxicology 2008.
FAU - Yang, Young-Su
AU  - Yang YS
AD  - 13Division of Inhalation Toxicology, Korea Institute of Toxicology, Korea 
      Research Institute of Chemical Technology, 1051 Shinjeong-dong, Jeongeup, 
      Jeollabuk-do, 580-185 Republic of Korea. GRID: grid.29869.3c. ISNI: 0000 0001 
      2296 8192
FAU - Yang, Mi-Jin
AU  - Yang MJ
AD  - 13Division of Inhalation Toxicology, Korea Institute of Toxicology, Korea 
      Research Institute of Chemical Technology, 1051 Shinjeong-dong, Jeongeup, 
      Jeollabuk-do, 580-185 Republic of Korea. GRID: grid.29869.3c. ISNI: 0000 0001 
      2296 8192
FAU - Cho, Kyu-Hyuk
AU  - Cho KH
AD  - 13Division of Inhalation Toxicology, Korea Institute of Toxicology, Korea 
      Research Institute of Chemical Technology, 1051 Shinjeong-dong, Jeongeup, 
      Jeollabuk-do, 580-185 Republic of Korea. GRID: grid.29869.3c. ISNI: 0000 0001 
      2296 8192
FAU - Lee, Kyuhong
AU  - Lee K
AD  - 13Division of Inhalation Toxicology, Korea Institute of Toxicology, Korea 
      Research Institute of Chemical Technology, 1051 Shinjeong-dong, Jeongeup, 
      Jeollabuk-do, 580-185 Republic of Korea. GRID: grid.29869.3c. ISNI: 0000 0001 
      2296 8192
FAU - Kim, Yong-Bum
AU  - Kim YB
AD  - 23Division of Toxicological Pathology, Korea institute of Toxicology, Daejeon, 
      305-343 Korea. GRID: grid.418982.e
FAU - Kim, Jin-Sung
AU  - Kim JS
AD  - 13Division of Inhalation Toxicology, Korea Institute of Toxicology, Korea 
      Research Institute of Chemical Technology, 1051 Shinjeong-dong, Jeongeup, 
      Jeollabuk-do, 580-185 Republic of Korea. GRID: grid.29869.3c. ISNI: 0000 0001 
      2296 8192
FAU - Kang, Myung-Gyun
AU  - Kang MG
AD  - 33Division of Toxicology, Korea institute of Toxicology, Daejeon, 305-343 Korea. 
      GRID: grid.418982.e
FAU - Song, Chang-Woo
AU  - Song CW
AD  - 13Division of Inhalation Toxicology, Korea Institute of Toxicology, Korea 
      Research Institute of Chemical Technology, 1051 Shinjeong-dong, Jeongeup, 
      Jeollabuk-do, 580-185 Republic of Korea. GRID: grid.29869.3c. ISNI: 0000 0001 
      2296 8192
FAU - Song, Chang-Woo
AU  - Song CW
AD  - 13Division of Inhalation Toxicology, Korea Institute of Toxicology, Korea 
      Research Institute of Chemical Technology, 1051 Shinjeong-dong, Jeongeup, 
      Jeollabuk-do, 580-185 Republic of Korea. GRID: grid.29869.3c. ISNI: 0000 0001 
      2296 8192
LA  - eng
PT  - Journal Article
DEP - 20081201
PL  - Singapore
TA  - Toxicol Res
JT  - Toxicological research
JID - 101483324
PMC - PMC7006295
OTO - NOTNLM
OT  - Asthma
OT  - Cytokine
OT  - Eosinophil
OT  - Immunoglobulin E
OT  - Model
OT  - Mouse
EDAT- 2008/12/01 00:00
MHDA- 2008/12/01 00:01
PMCR- 2009/12/01
CRDT- 2020/02/11 06:00
PHST- 2008/08/13 00:00 [received]
PHST- 2008/11/07 00:00 [revised]
PHST- 2008/11/07 00:00 [accepted]
PHST- 2020/02/11 06:00 [entrez]
PHST- 2008/12/01 00:00 [pubmed]
PHST- 2008/12/01 00:01 [medline]
PHST- 2009/12/01 00:00 [pmc-release]
AID - 2404253 [pii]
AID - 10.5487/TR.2008.24.4.253 [doi]
PST - ppublish
SO  - Toxicol Res. 2008 Dec;24(4):253-261. doi: 10.5487/TR.2008.24.4.253. Epub 2008 Dec 
      1.