PMID- 32038804
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1976-8257 (Print)
IS  - 2234-2753 (Electronic)
IS  - 1976-8257 (Linking)
VI  - 24
IP  - 4
DP  - 2008 Dec
TI  - Effects of Exposure Period on the Developmental Toxicity of 2-Bromopropane in 
      Sprague-Dawley Rats.
PG  - 263-271
LID - 10.5487/TR.2008.24.4.263 [doi]
AB  - Recently we reported that 2-bromopropane (2-BP) has maternal toxicity, 
      embryotoxicity, and teratogenicity in Sprague-Dawley rats. The aims of this study 
      are to examine the potential effects of 2-BP administration on pregnant dams and 
      embryo-fetal development, and to investigate the effects of metabolic activation 
      induced by phenobarbital (PB) on developmental toxicities of 2-BP. Pregnant rats 
      received 1000 mg/kg/day subcutaneous 2-BP injections on gestational days (GD) 6 
      through 10 (Group II and Group IIII) or 11 through 15 (Group IV). Pregnant rats 
      in Group III received an intraperitoneal PB injection once daily at 80 mg/kg/day 
      on GD 3 through 5 for induction of the liver metabolic enzyme system. Control 
      rats received vehicle injections only on GD 6 through 15. All dams underwent 
      caesarean sections on GD 20 and their fetuses were examined for external, 
      visceral, and skeletal abnormalities. Significant adverse effects on pregnant 
      dams and embryo-fetal development were observed in all the treatment groups, and 
      the maternal and embryo-fetal effects of 2-BP observed in Group II were higher 
      than those seen in Group IV. Conversely, maternal and embryo-fetal developmental 
      toxicities observed in Group III were comparable to those seen in Group II. These 
      results suggest that the potential effects of 2-BP on pregnant dams and 
      embryo-fetal development are more likely in the first half of organogenesis (days 
      6~10 of pregnancy) than in the second half and that the metabolic activation 
      induced by PB pre-treatment did not modify the developmental toxic effects of 
      2-BP in rats.
CI  - (c) Korean Society of Toxicology 2008.
FAU - Shin, In-Sik
AU  - Shin IS
AD  - Animal Medical Center, College of Veterinary Medicine, Chonnam National 
      University, Gwangju, 500-757 Korea. GRID: grid.14005.30. ISNI: 0000 0001 0356 
      9399
FAU - Lee, Jong-Chan
AU  - Lee JC
AD  - Animal Medical Center, College of Veterinary Medicine, Chonnam National 
      University, Gwangju, 500-757 Korea. GRID: grid.14005.30. ISNI: 0000 0001 0356 
      9399
FAU - Kim, Kang-Hyeon
AU  - Kim KH
AD  - Animal Medical Center, College of Veterinary Medicine, Chonnam National 
      University, Gwangju, 500-757 Korea. GRID: grid.14005.30. ISNI: 0000 0001 0356 
      9399
FAU - Ahn, Tai-Hwan
AU  - Ahn TH
AD  - Animal Medical Center, College of Veterinary Medicine, Chonnam National 
      University, Gwangju, 500-757 Korea. GRID: grid.14005.30. ISNI: 0000 0001 0356 
      9399
FAU - Bae, Chun-Sik
AU  - Bae CS
AD  - Animal Medical Center, College of Veterinary Medicine, Chonnam National 
      University, Gwangju, 500-757 Korea. GRID: grid.14005.30. ISNI: 0000 0001 0356 
      9399
FAU - Moon, Changjong
AU  - Moon C
AD  - Animal Medical Center, College of Veterinary Medicine, Chonnam National 
      University, Gwangju, 500-757 Korea. GRID: grid.14005.30. ISNI: 0000 0001 0356 
      9399
FAU - Kim, Sung-Ho
AU  - Kim SH
AD  - Animal Medical Center, College of Veterinary Medicine, Chonnam National 
      University, Gwangju, 500-757 Korea. GRID: grid.14005.30. ISNI: 0000 0001 0356 
      9399
FAU - Shin, Dong-Ho
AU  - Shin DH
AD  - Animal Medical Center, College of Veterinary Medicine, Chonnam National 
      University, Gwangju, 500-757 Korea. GRID: grid.14005.30. ISNI: 0000 0001 0356 
      9399
FAU - Kim, Jong-Choon
AU  - Kim JC
AD  - Animal Medical Center, College of Veterinary Medicine, Chonnam National 
      University, Gwangju, 500-757 Korea. GRID: grid.14005.30. ISNI: 0000 0001 0356 
      9399
LA  - eng
PT  - Journal Article
DEP - 20081201
PL  - Singapore
TA  - Toxicol Res
JT  - Toxicological research
JID - 101483324
PMC - PMC7006275
OTO - NOTNLM
OT  - 2-Bromopropane
OT  - Embryotoxicity
OT  - Metabolic activation
OT  - Rats
OT  - Susceptible period
OT  - Teratogenicity
EDAT- 2008/12/01 00:00
MHDA- 2008/12/01 00:01
PMCR- 2009/12/01
CRDT- 2020/02/11 06:00
PHST- 2008/08/14 00:00 [received]
PHST- 2008/09/01 00:00 [revised]
PHST- 2008/09/02 00:00 [accepted]
PHST- 2020/02/11 06:00 [entrez]
PHST- 2008/12/01 00:00 [pubmed]
PHST- 2008/12/01 00:01 [medline]
PHST- 2009/12/01 00:00 [pmc-release]
AID - 2404263 [pii]
AID - 10.5487/TR.2008.24.4.263 [doi]
PST - ppublish
SO  - Toxicol Res. 2008 Dec;24(4):263-271. doi: 10.5487/TR.2008.24.4.263. Epub 2008 Dec 
      1.