PMID- 32038809
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1976-8257 (Print)
IS  - 2234-2753 (Electronic)
IS  - 1976-8257 (Linking)
VI  - 24
IP  - 4
DP  - 2008 Dec
TI  - Evaluation of Maternal Toxicity in Rats Exposed to 1,3-Dichloro-2-propanol during 
      Pregnancy.
PG  - 307-314
LID - 10.5487/TR.2008.24.4.307 [doi]
AB  - The present study was carried out to investigate the potential adverse effects of 
      1,3-dichloro-2-propanol on pregnant dams after maternal exposure during the 
      gestational days (GD) 6 through 19 in Sprague-Dawley rats. The tested chemical 
      was administered orally to pregnant rats at dose levels of 0, 10, 30, or 90 
      mg/kg/day. During the test period, clinical signs, mortality, body weights, food 
      consumption, serum biochemistry, gross findings, organ weights, and Caesarean 
      section findings were examined. In the 90 mg/kg group, decreases in the body 
      weight gain and food consumption, and increases in the weights of liver and 
      adrenal glands were observed. Serum biochemical investigations revealed increases 
      in aspartate aminotransferase (AST), alanine aminotransferase (ALT), cholesterol 
      (CHO), triglyceride (TG), alkaline phosphatase (ALP), and bilirubin (BIL) and 
      decreases in glucose (GLU), albumin (ALB) and total protein (TP). In the 30 mg/kg 
      group, a decrease in the food consumption and an increase in the liver weight 
      were observed. Serum biochemical investigation also showed increases in CHO and 
      TG and a decrease in glucose. Since there were no signs of maternal toxicity in 
      the 10 mg/kg group, it is considered to be the no-observed-adverse-effect level 
      (NOAEL) of 1,3-dichloro-2-propanol. It is concluded that successive oral 
      administration of 1,3-dichloro-2-propanol to pregnant rats for 14 days may cause 
      significant toxicities in body weight and liver at a dose rate >/= 30 mg/kg/day.
CI  - (c) Korean Society of Toxicology 2008.
FAU - Lee, Jong-Chan
AU  - Lee JC
AD  - Animal Medical Center, College of Veterinary Medicine, Chonnam National 
      University, Gwangju, 500-757 Korea. GRID: grid.14005.30. ISNI: 0000 0001 0356 
      9399
FAU - Shin, In-Sik
AU  - Shin IS
AD  - Animal Medical Center, College of Veterinary Medicine, Chonnam National 
      University, Gwangju, 500-757 Korea. GRID: grid.14005.30. ISNI: 0000 0001 0356 
      9399
FAU - Kim, Gang-Hyeon
AU  - Kim GH
AD  - Animal Medical Center, College of Veterinary Medicine, Chonnam National 
      University, Gwangju, 500-757 Korea. GRID: grid.14005.30. ISNI: 0000 0001 0356 
      9399
FAU - Park, Na-Hyeong
AU  - Park NH
AD  - Animal Medical Center, College of Veterinary Medicine, Chonnam National 
      University, Gwangju, 500-757 Korea. GRID: grid.14005.30. ISNI: 0000 0001 0356 
      9399
FAU - Moon, Chang-Jong
AU  - Moon CJ
AD  - Animal Medical Center, College of Veterinary Medicine, Chonnam National 
      University, Gwangju, 500-757 Korea. GRID: grid.14005.30. ISNI: 0000 0001 0356 
      9399
FAU - Bae, Chun-Sik
AU  - Bae CS
AD  - Animal Medical Center, College of Veterinary Medicine, Chonnam National 
      University, Gwangju, 500-757 Korea. GRID: grid.14005.30. ISNI: 0000 0001 0356 
      9399
FAU - Kang, Sung-Soo
AU  - Kang SS
AD  - Animal Medical Center, College of Veterinary Medicine, Chonnam National 
      University, Gwangju, 500-757 Korea. GRID: grid.14005.30. ISNI: 0000 0001 0356 
      9399
FAU - Kim, Sung-Ho
AU  - Kim SH
AD  - Animal Medical Center, College of Veterinary Medicine, Chonnam National 
      University, Gwangju, 500-757 Korea. GRID: grid.14005.30. ISNI: 0000 0001 0356 
      9399
FAU - Shin, Dong-Ho
AU  - Shin DH
AD  - Animal Medical Center, College of Veterinary Medicine, Chonnam National 
      University, Gwangju, 500-757 Korea. GRID: grid.14005.30. ISNI: 0000 0001 0356 
      9399
FAU - Kim, Jong-Choon
AU  - Kim JC
AD  - Animal Medical Center, College of Veterinary Medicine, Chonnam National 
      University, Gwangju, 500-757 Korea. GRID: grid.14005.30. ISNI: 0000 0001 0356 
      9399
LA  - eng
PT  - Journal Article
DEP - 20081201
PL  - Singapore
TA  - Toxicol Res
JT  - Toxicological research
JID - 101483324
PMC - PMC7006251
OTO - NOTNLM
OT  - 1,3-Dichloro-2-propanol
OT  - Maternal toxicity
OT  - Pregnancy
OT  - Rats
OT  - Serum biochemistry
EDAT- 2008/12/01 00:00
MHDA- 2008/12/01 00:01
PMCR- 2009/12/01
CRDT- 2020/02/11 06:00
PHST- 2008/08/06 00:00 [received]
PHST- 2008/11/04 00:00 [revised]
PHST- 2008/11/05 00:00 [accepted]
PHST- 2020/02/11 06:00 [entrez]
PHST- 2008/12/01 00:00 [pubmed]
PHST- 2008/12/01 00:01 [medline]
PHST- 2009/12/01 00:00 [pmc-release]
AID - 2404307 [pii]
AID - 10.5487/TR.2008.24.4.307 [doi]
PST - ppublish
SO  - Toxicol Res. 2008 Dec;24(4):307-314. doi: 10.5487/TR.2008.24.4.307. Epub 2008 Dec 
      1.